公开(公告)号：US5290692A

公开(公告)日：1994-03-01

申请号：US852539

申请日：1992-03-17

申请人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto

发明人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto

IPC分类号： A61K38/16 ,  A61K38/46 ,  A61K38/49 ,  A61K47/02 ,  A61K47/48 ,  A61L33/00 ,  A61P7/02 ,  C12N11/14 ,  A61K37/54

CPC分类号： A61K47/48861 ,  A61K38/166 ,  A61K38/49 ,  A61L33/0047 ,  C12N11/14

摘要： A fibrinolytic enzyme such as urokinase, tissue plasminogen activator or streptokinase is covalently bounded to a bioadaptable porous crystalline glass to produce a thrombolytic material. Production of the glass involves combining 40-50 mol% calcium oxide, 20-30 mol% titanium dioxide and 25-35 mol% diphosphorous pentoxide to form a mixture, and combining the mixture with 0.5-4.0 mol% disodium oxide. A bioreactor for converting plasminogen in blood into plasmin can be prepared by packing the material in a column. When finely comminuted, the material can be administered into the blood of a patient for removing blood clots.

摘要翻译： 纤维蛋白溶解酶如尿激酶，组织纤溶酶原激活剂或链激酶与生物适应性多孔结晶玻璃共价结合以产生溶栓物质。 玻璃的生产涉及组合40-50摩尔％的氧化钙，20-30摩尔％的二氧化钛和25-35摩尔％的二氧化磷二氧化物以形成混合物，并将该混合物与0.5-4.0摩尔％的二氧化钠组合。 用于将血液中的纤溶酶原转化成纤溶酶的生物反应器可以通过在柱中包装材料来制备。 当细粉碎时，可以将该物质施用于患者的血液中以除去血块。

公开(公告)号：US5178901A

公开(公告)日：1993-01-12

申请号：US618750

申请日：1990-11-27

申请人： Motohiro Toriyama ,  Sukezo Kawamura ,  Yukari Kawamoto ,  Yoshiyuki Yokogawa ,  Takahiro Suzuki

发明人： Motohiro Toriyama ,  Sukezo Kawamura ,  Yukari Kawamoto ,  Yoshiyuki Yokogawa ,  Takahiro Suzuki

IPC分类号： A61L27/00 ,  A61C8/00 ,  A61F2/00 ,  A61F2/30 ,  A61L27/32 ,  C01G23/00 ,  C03C3/21 ,  C03C8/08 ,  C23D1/02 ,  C23D5/02

CPC分类号： C23D5/02 ,  A61C8/0012 ,  A61F2/30767 ,  A61L27/32 ,  C03C3/21 ,  C03C8/08 ,  A61C8/0013 ,  A61F2310/00796

摘要： A powder for coating the surface of a titanium metal is obtained by mixing compounds as raw materials for CaO, TiO.sub.2, and P.sub.2 O.sub.5 with a small amount of a Na.sub.2 O-containing compound, fusing the resultant mixture, and solidifying and pulverizing the fused mixture. A coating of a calcium phosphate compound adhering with great fastness to the surface of the titanium metal is formed by preparing an aqueous slurry containing the powder mentioned above, applying the aqueous slurry to the surface of the titanium metal, and heat-treating the coated titanium metal.

摘要翻译： 通过将化合物作为CaO，TiO 2和P 2 O 5的原料与少量含有Na 2 O的化合物混合，将所得混合物熔合并固化和粉碎熔融混合物，得到用于涂覆钛金属表面的粉末。 通过制备含有上述粉末的含水浆料，将该水性浆液施加到钛金属的表面，并对该涂覆的钛进行热处理，形成具有坚固牢度的钛金属表面的磷酸钙化合物的涂层 金属。

公开(公告)号：US5077079A

公开(公告)日：1991-12-31

申请号：US652995

申请日：1991-02-08

申请人： Sukezo Kawamura ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto ,  Motohiro Toriyama ,  Takahiro Suzuki

发明人： Sukezo Kawamura ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto ,  Motohiro Toriyama ,  Takahiro Suzuki

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/28 ,  A61L27/32 ,  C04B41/50 ,  C04B41/85 ,  C04B41/89

CPC分类号： C04B41/009 ,  A61L27/32 ,  C04B41/5092 ,  C04B41/85 ,  A61F2310/00796 ,  C04B2111/00836

摘要： A dense coating of a calcium phosphate compound is formed on the surface of a bioadaptable ceramic substrate by applying to the ceramic calcium metaphosphate alone or a mixture of calcium metaphosphate with calcium pyrophosphate, heat-treating the applied layer thereby fusing the applied layer to the surface of the ceramic, then applying to the fused layer a slurry resulting from the mixture of calcium metaphosphate with tetracalcium phosphate, and subsequently heat-treating the applied layer of the slurry thereby inducing reaction of the slurry.

摘要翻译： 通过将陶瓷钙偏磷酸盐或偏磷酸钙与焦磷酸钙的混合物应用于生物适应性陶瓷基材的表面上，形成致密的磷酸钙化合物涂层，对施加的层进行热处理，从而将施加的层融合到表面 的陶瓷，然后向熔融层施加由偏磷酸钙与磷酸四钙的混合物产生的浆料，随后对所施加的浆料层进行热处理，从而引起浆料的反应。

公开(公告)号：US5491082A

公开(公告)日：1996-02-13

申请号：US246940

申请日：1994-05-20

申请人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokokawa ,  Yukari Kawamoto ,  Yasuharu Hakamatsuka ,  Hiroyuki Irie

发明人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokokawa ,  Yukari Kawamoto ,  Yasuharu Hakamatsuka ,  Hiroyuki Irie

IPC分类号： A61K38/00 ,  C12N9/72 ,  C12N11/14 ,  A61K38/48

CPC分类号： C12N9/6456 ,  C12N11/14 ,  A61K38/00

摘要： A plasminogen activator such as urokinase or tissue plasminogen activator is covalently bonded to a porous body composed of calcium phosphate to form a plasminogen activator-porous body complex. The tricalcium phosphate can be .alpha.-tricalcium phosphate, .beta.-tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, octacalcium phosphate and mixtures thereof. In a preferred embodiment, .beta.-tricalcium phosphate which has excellent biocompatibility with the body or a mixture of .beta.-tricalcium phosphate and hydroxyapatite is used. Preferably, synthetic calcium phosphate is used is to avoid impurities contained by natural calcium phosphate. Covalent bonding is by crosslinking with glutaraldehyde, bismaleimides, dihalogenic aryls or diisocyanates, or by using cyanogen bromide, diazotization or periodic acid. The complex can be filled into a column to form a bioreactor. A granular complex can be intravascularly injected into the blood of a patient to provide thrombotic activity for a long period of time. In another embodiment, a complex of a predetermined shape can be implanted to provide thrombotic activity.

摘要翻译： 纤维蛋白溶酶原激活剂如尿激酶或组织纤溶酶原激活剂共价键合到由磷酸钙组成的多孔体上以形成纤溶酶原激活剂多孔体复合体。 磷酸三钙可以是α-磷酸三钙，β-磷酸三钙，羟基磷灰石，磷酸四钙，磷酸八钙及其混合物。 在优选的实施方案中，使用与身体具有优异生物相容性的β-磷酸三钙或磷酸β-磷酸钙和羟基磷灰石的混合物。 优选地，合成磷酸钙是为了避免天然磷酸钙含有的杂质。 共价键是通过与戊二醛，双马来酰亚胺，二卤代芳基或二异氰酸酯交联，或通过使用溴化氰，重氮化或高碘酸进行交联。 复合物可以填充到柱中以形成生物反应器。 颗粒状复合物可以血管内注射到患者的血液中以长时间提供血栓形成活性。 在另一个实施方案中，可以植入预定形状的复合物以提供血栓形成活性。

公开(公告)号：US4770943A

公开(公告)日：1988-09-13

申请号：US123221

申请日：1987-11-20

申请人： Yasuharu Hakamatsuka ,  Sukezo Kawamura ,  Motohiro Toriyama

发明人： Yasuharu Hakamatsuka ,  Sukezo Kawamura ,  Motohiro Toriyama

IPC分类号： C04B41/87 ,  A61F2/00 ,  A61L27/00 ,  A61L27/32 ,  C04B41/52 ,  C04B41/89 ,  C23C22/03 ,  B05D1/36 ,  B05D3/02 ,  B05D7/00 ,  B32B9/00

CPC分类号： A61L27/32 ,  C04B41/009 ,  C04B41/52 ,  C04B41/89 ,  A61F2310/00796 ,  C04B2103/008 ,  C04B2111/00836

摘要： A method of forming a rigid film of calcium phosphate compound having good bio-conformance on a surface of a ceramic or metal substrate is disclosed. According to this method, a slurry of a fine powder of phosphate-series glass of CaO-Na.sub.2 O-P.sub.2 O.sub.5 -Al.sub.2 O.sub.3 is applied to the surface of the substrate and is dried and heat-treated to form a binder layer which covers the surface of the substrate. A peptisation agent such as ammonium polyacrylate and water are mixed with a fine powder of a calcium phosphate compound having a particle size of 1 .mu.m or less to prepare a slurry, and this slurry is applied to the surface of the binder layer. The slurry on the binder layer is dried and heat-treated to form a film of the calcium phosphate compound. The film of the calcium phosphate compound formed by this method is uniform and has high adhesion strength with the substrate.

摘要翻译： 公开了一种在陶瓷或金属基材的表面上形成具有良好生物一致性的磷酸钙化合物刚性膜的方法。 根据该方法，将CaO-Na 2 O-P 2 O 5·Al 2 O 3的磷酸盐系玻璃微粉的浆料涂布在基材的表面上，进行干燥，热处理，形成覆盖表面的粘合剂层 基质。 将聚丙烯酸铵和水等胶溶剂与粒径为1μm以下的磷酸钙化合物的细粉末混合，制成浆料，将该浆料涂布在粘合剂层的表面。 将粘合剂层上的浆料干燥并热处理以形成磷酸钙化合物的膜。 通过该方法形成的磷酸钙化合物的膜是均匀的并且与基材具有高粘附强度。

公开(公告)号：US5322675A

公开(公告)日：1994-06-21

申请号：US4777

申请日：1993-01-14

申请人： Yasuharu Hakamatsuka ,  Hiroyuki Irie ,  Sukezo Kawamura ,  Motohiro Toriyama

发明人： Yasuharu Hakamatsuka ,  Hiroyuki Irie ,  Sukezo Kawamura ,  Motohiro Toriyama

IPC分类号： C01B25/32 ,  C04B35/447

CPC分类号： C04B35/447 ,  C01B25/327

摘要： Powdery calcium carbonate and a powdery dihydrate of calcium monohydrogenohosphate are weighed to get a Ca/P ratio of 1.45 to 1.67. The powdery mixture thus prepared is then added pure water at a temperature of 30.degree. C. or higher to obtain an aqueous slurry having a concentration of about 10% by weight. Thereafter, the aqueous slurry is subjected to a rotational attrition by using a ball mill to conduct a mechanochemical reaction of the calcium carbonate with the dihydrate of calcium monohydrogenphosphate. The slurry is then dried completely at 80.degree. C., followed by pulverization to yield a dry powder of calcium phosphate hydrate. The dry powder is calcinated at a temperature ranging from 720.degree. to 1,150.degree. C. for 1-10 hours or more to give calcium phosphate powder, which is molded in a desired shape and is sintered at a certain temperature to obtain a sintered body of calcium phosphate. The calcium phosphate and the sintered body thereof, thus prepared, have an assured biological safety in that the calcium phosphate is free from hemolysis, antigenicity and cytotoxicity.

摘要翻译： 称量粉状碳酸钙和一水合磷酸二氢钙粉末，得到1.45〜1.67的Ca / P比。 然后将如此制备的粉末混合物在30℃或更高的温度下加入纯水，得到浓度为约10重量％的含水浆料。 然后，使用球磨机对含水浆料进行旋转磨耗，进行碳酸钙与磷酸一氢钙的二水合物的机械化学反应。 然后将浆液在80℃下完全干燥，随后粉碎，得到磷酸钙水合物的干燥粉末。 将干燥粉末在720〜1150℃的温度下煅烧1-10小时以上，得到磷酸钙粉末，其以所需形状成型并在一定温度下烧结，得到烧结体 磷酸钙 由此制备的磷酸钙及其烧结体具有确保的生物安全性，因为磷酸钙不含溶血，抗原性和细胞毒性。

公开(公告)号：US4752457A

公开(公告)日：1988-06-21

申请号：US89424

申请日：1987-08-26

申请人： Motohiro Toriyama ,  Sukezo Kawamura

发明人： Motohiro Toriyama ,  Sukezo Kawamura

IPC分类号： C01B25/32

CPC分类号： C01B25/325

摘要： Porous spheres of calcium phosphate compound are produced by preparing an aqueous solution containing a water-soluble calcium salt, a calcium ion complexing agent, and a water-soluble phosphate, adjusting the pH of the aqueous solution, adding hydrogen peroxide to the aqueous solution, and heating the resultant mixture.

摘要翻译： 通过制备含有水溶性钙盐，钙离子络合剂和水溶性磷酸盐的水溶液，调节水溶液的pH，向水溶液中加入过氧化氢，制备磷酸钙化合物的多孔球， 并加热所得混合物。

公开(公告)号：US4988362A

公开(公告)日：1991-01-29

申请号：US319757

申请日：1989-03-07

申请人： Motohiro Toriyama ,  Sukezo Kawamura

发明人： Motohiro Toriyama ,  Sukezo Kawamura

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61L27/12 ,  A61L27/32 ,  C12P7/08

CPC分类号： A61L27/12 ,  A61L27/32 ,  A61F2310/00293 ,  A61F2310/00796 ,  Y10S623/92

摘要： A composition produced as a result of mixing alumina, silica, and a calcium phosphate compound in a specific ratio exhibits high affinity for bioceramics. When a bioceramic is coated with this composition and the coated bioceramic is heated, the composite is fused fast with the bioceramic to produce a composition bioceramic which is active to vital tissues.

摘要翻译： 通过以特定比例混合氧化铝，二氧化硅和磷酸钙化合物而生产的组合物对生物陶瓷具有高亲和力。 当用该组合物涂覆生物陶瓷并且涂覆的生物陶瓷被加热时，复合材料与生物陶瓷快速熔合以产生对生物组织有活性的组合物生物陶瓷。

公开(公告)号：US4772573A

公开(公告)日：1988-09-20

申请号：US69

申请日：1987-01-02

申请人： Motohiro Toriyama ,  Sukezo Kawamura

发明人： Motohiro Toriyama ,  Sukezo Kawamura

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B35/447 ,  C04B35/02

CPC分类号： A61L27/12 ,  A61K6/0044 ,  A61K6/0215 ,  A61K6/033 ,  C04B35/447 ,  A61F2310/00293

摘要： Sintered article suitable for artificial bones, for example, containing a calcium phosphate compound as a main component and additionally containing spinel or magnesium oxide formed by sintering magnesium oxalate dihydrate. This sintered article is produced by adding alumina and silica or magnesium oxalate dihydrate to a calcium phosphate compound and firing the resultant mixture.

摘要翻译： 适用于人造骨的烧结制品，例如含有磷酸钙化合物作为主要成分，另外含有通过烧结草酸二水合物形成的尖晶石或氧化镁。 该烧结制品通过向磷酸钙化合物中加入氧化铝和二氧化硅或草酸镁二水合物并焙烧所得混合物来制备。

公开(公告)号：US4717556A

公开(公告)日：1988-01-05

申请号：US916746

申请日：1986-10-08

申请人： Sukezo Kawamura ,  Motohiro Toriyama

发明人： Sukezo Kawamura ,  Motohiro Toriyama

IPC分类号： C01B25/32 ,  C01B15/16

CPC分类号： C01B25/327

摘要： A microfine .beta.-tricalcium phosphate powder is produced by mixing hydrogen calcium phosphate powder, calcium carbonate powder, and water in amounts calculated to give a slurry having a solids concentration in the range of 5 to 15% by weight and a CA:P atomic ratio in the range of 1:1.4.about.1.6 and subjecting the slurry to attrition.

摘要翻译： 通过混合磷酸氢钙粉末，碳酸钙粉末和水来制备微细β-磷酸三钙粉末，其量为计算得到固体浓度在5至15重量％范围内的浆料和CA:P原子比 在1：1.4差异1.6的范围内，并使浆料磨损。