公开(公告)号：US5178901A

公开(公告)日：1993-01-12

申请号：US618750

申请日：1990-11-27

申请人： Motohiro Toriyama ,  Sukezo Kawamura ,  Yukari Kawamoto ,  Yoshiyuki Yokogawa ,  Takahiro Suzuki

发明人： Motohiro Toriyama ,  Sukezo Kawamura ,  Yukari Kawamoto ,  Yoshiyuki Yokogawa ,  Takahiro Suzuki

IPC分类号： A61L27/00 ,  A61C8/00 ,  A61F2/00 ,  A61F2/30 ,  A61L27/32 ,  C01G23/00 ,  C03C3/21 ,  C03C8/08 ,  C23D1/02 ,  C23D5/02

CPC分类号： C23D5/02 ,  A61C8/0012 ,  A61F2/30767 ,  A61L27/32 ,  C03C3/21 ,  C03C8/08 ,  A61C8/0013 ,  A61F2310/00796

摘要： A powder for coating the surface of a titanium metal is obtained by mixing compounds as raw materials for CaO, TiO.sub.2, and P.sub.2 O.sub.5 with a small amount of a Na.sub.2 O-containing compound, fusing the resultant mixture, and solidifying and pulverizing the fused mixture. A coating of a calcium phosphate compound adhering with great fastness to the surface of the titanium metal is formed by preparing an aqueous slurry containing the powder mentioned above, applying the aqueous slurry to the surface of the titanium metal, and heat-treating the coated titanium metal.

摘要翻译： 通过将化合物作为CaO，TiO 2和P 2 O 5的原料与少量含有Na 2 O的化合物混合，将所得混合物熔合并固化和粉碎熔融混合物，得到用于涂覆钛金属表面的粉末。 通过制备含有上述粉末的含水浆料，将该水性浆液施加到钛金属的表面，并对该涂覆的钛进行热处理，形成具有坚固牢度的钛金属表面的磷酸钙化合物的涂层 金属。

公开(公告)号：US5290692A

公开(公告)日：1994-03-01

申请号：US852539

申请日：1992-03-17

申请人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto

发明人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto

IPC分类号： A61K38/16 ,  A61K38/46 ,  A61K38/49 ,  A61K47/02 ,  A61K47/48 ,  A61L33/00 ,  A61P7/02 ,  C12N11/14 ,  A61K37/54

CPC分类号： A61K47/48861 ,  A61K38/166 ,  A61K38/49 ,  A61L33/0047 ,  C12N11/14

摘要： A fibrinolytic enzyme such as urokinase, tissue plasminogen activator or streptokinase is covalently bounded to a bioadaptable porous crystalline glass to produce a thrombolytic material. Production of the glass involves combining 40-50 mol% calcium oxide, 20-30 mol% titanium dioxide and 25-35 mol% diphosphorous pentoxide to form a mixture, and combining the mixture with 0.5-4.0 mol% disodium oxide. A bioreactor for converting plasminogen in blood into plasmin can be prepared by packing the material in a column. When finely comminuted, the material can be administered into the blood of a patient for removing blood clots.

摘要翻译： 纤维蛋白溶解酶如尿激酶，组织纤溶酶原激活剂或链激酶与生物适应性多孔结晶玻璃共价结合以产生溶栓物质。 玻璃的生产涉及组合40-50摩尔％的氧化钙，20-30摩尔％的二氧化钛和25-35摩尔％的二氧化磷二氧化物以形成混合物，并将该混合物与0.5-4.0摩尔％的二氧化钠组合。 用于将血液中的纤溶酶原转化成纤溶酶的生物反应器可以通过在柱中包装材料来制备。 当细粉碎时，可以将该物质施用于患者的血液中以除去血块。

公开(公告)号：US5077079A

公开(公告)日：1991-12-31

申请号：US652995

申请日：1991-02-08

申请人： Sukezo Kawamura ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto ,  Motohiro Toriyama ,  Takahiro Suzuki

发明人： Sukezo Kawamura ,  Yoshiyuki Yokogawa ,  Yukari Kawamoto ,  Motohiro Toriyama ,  Takahiro Suzuki

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/28 ,  A61L27/32 ,  C04B41/50 ,  C04B41/85 ,  C04B41/89

CPC分类号： C04B41/009 ,  A61L27/32 ,  C04B41/5092 ,  C04B41/85 ,  A61F2310/00796 ,  C04B2111/00836

摘要： A dense coating of a calcium phosphate compound is formed on the surface of a bioadaptable ceramic substrate by applying to the ceramic calcium metaphosphate alone or a mixture of calcium metaphosphate with calcium pyrophosphate, heat-treating the applied layer thereby fusing the applied layer to the surface of the ceramic, then applying to the fused layer a slurry resulting from the mixture of calcium metaphosphate with tetracalcium phosphate, and subsequently heat-treating the applied layer of the slurry thereby inducing reaction of the slurry.

摘要翻译： 通过将陶瓷钙偏磷酸盐或偏磷酸钙与焦磷酸钙的混合物应用于生物适应性陶瓷基材的表面上，形成致密的磷酸钙化合物涂层，对施加的层进行热处理，从而将施加的层融合到表面 的陶瓷，然后向熔融层施加由偏磷酸钙与磷酸四钙的混合物产生的浆料，随后对所施加的浆料层进行热处理，从而引起浆料的反应。

公开(公告)号：US5491082A

公开(公告)日：1996-02-13

申请号：US246940

申请日：1994-05-20

申请人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokokawa ,  Yukari Kawamoto ,  Yasuharu Hakamatsuka ,  Hiroyuki Irie

发明人： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokokawa ,  Yukari Kawamoto ,  Yasuharu Hakamatsuka ,  Hiroyuki Irie

IPC分类号： A61K38/00 ,  C12N9/72 ,  C12N11/14 ,  A61K38/48

CPC分类号： C12N9/6456 ,  C12N11/14 ,  A61K38/00

摘要： A plasminogen activator such as urokinase or tissue plasminogen activator is covalently bonded to a porous body composed of calcium phosphate to form a plasminogen activator-porous body complex. The tricalcium phosphate can be .alpha.-tricalcium phosphate, .beta.-tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, octacalcium phosphate and mixtures thereof. In a preferred embodiment, .beta.-tricalcium phosphate which has excellent biocompatibility with the body or a mixture of .beta.-tricalcium phosphate and hydroxyapatite is used. Preferably, synthetic calcium phosphate is used is to avoid impurities contained by natural calcium phosphate. Covalent bonding is by crosslinking with glutaraldehyde, bismaleimides, dihalogenic aryls or diisocyanates, or by using cyanogen bromide, diazotization or periodic acid. The complex can be filled into a column to form a bioreactor. A granular complex can be intravascularly injected into the blood of a patient to provide thrombotic activity for a long period of time. In another embodiment, a complex of a predetermined shape can be implanted to provide thrombotic activity.

摘要翻译： 纤维蛋白溶酶原激活剂如尿激酶或组织纤溶酶原激活剂共价键合到由磷酸钙组成的多孔体上以形成纤溶酶原激活剂多孔体复合体。 磷酸三钙可以是α-磷酸三钙，β-磷酸三钙，羟基磷灰石，磷酸四钙，磷酸八钙及其混合物。 在优选的实施方案中，使用与身体具有优异生物相容性的β-磷酸三钙或磷酸β-磷酸钙和羟基磷灰石的混合物。 优选地，合成磷酸钙是为了避免天然磷酸钙含有的杂质。 共价键是通过与戊二醛，双马来酰亚胺，二卤代芳基或二异氰酸酯交联，或通过使用溴化氰，重氮化或高碘酸进行交联。 复合物可以填充到柱中以形成生物反应器。 颗粒状复合物可以血管内注射到患者的血液中以长时间提供血栓形成活性。 在另一个实施方案中，可以植入预定形状的复合物以提供血栓形成活性。

公开(公告)号：US5698265A

公开(公告)日：1997-12-16

申请号：US607885

申请日：1996-02-27

申请人： Michael Roger Mucalo ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Fukue Nagata ,  Hajime Nagae

发明人： Michael Roger Mucalo ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Fukue Nagata ,  Hajime Nagae

IPC分类号： B01J20/281 ,  C01B25/32 ,  D06M11/00 ,  D06M11/71 ,  D06M101/00 ,  D06M101/02 ,  D06M101/06 ,  D21C9/00 ,  D21H17/67 ,  G01N30/88 ,  B05D3/04

CPC分类号： D21C9/002 ,  D06M11/71

摘要： A method for the production of a composite consisting of cellulose fibers coated with a calcium phosphate compound consists essentially of phosphorylating the surface of cellulose fibers, immersing the surface-phosphorylated cellulose fibers in an aqueous solution containing calcium ions and hydroxyl ions, removing the cellulose fibers from the aqueous solution and subsequently immersing them in an aqueous solution containing calcium ions and phosphoric acid ions, and then removing the cellulose fibers from the aqueous solution. Also disclosed is a composite produced by the method.

摘要翻译： 制备由磷酸钙化合物涂覆的纤维素纤维组成的复合材料的方法主要包括磷酸化纤维素纤维的表面，将表面磷酸化的纤维素纤维浸入含有钙离子和羟基离子的水溶液中，除去纤维素纤维 然后将其浸入含有钙离子和磷酸离子的水溶液中，然后从水溶液中除去纤维素纤维。 还公开了通过该方法制备的复合材料。

公开(公告)号：US5427754A

公开(公告)日：1995-06-27

申请号：US174264

申请日：1993-12-28

申请人： Fukue Nagata ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Hajime Nagae

发明人： Fukue Nagata ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Hajime Nagae

IPC分类号： B01J20/281 ,  C01B25/32 ,  C30B29/14 ,  C30B29/64 ,  G01N30/88

CPC分类号： C01B25/327

摘要： A platelike hydroxyapatite is produced by preparing from a phosphate and a calcium salt an aqueous slurry of amorphous calcium phosphate having an atomic ratio of calcium atoms to phosphorus atoms in the range of 1.3:1 to 2.0:1, adding to the aqueous slurry not less than 10% by weight of alcohol based on the amount of the aqueous slurry, and subjecting the resultant mixture to a hydrothermal treatment.

摘要翻译： 通过从磷酸盐和钙盐制备具有1.3:1至2.0:1的钙原子与磷原子之比的无定形磷酸钙的水性浆料制备板状羟基磷灰石，不少于 相对于含水浆料的量为10重量％以上的醇，并对所得混合物进行水热处理。

公开(公告)号：US6153266A

公开(公告)日：2000-11-28

申请号：US206265

申请日：1998-12-07

申请人： Yoshiyuki Yokogawa ,  Tetsuya Kameyama ,  Yukari Kawamoto ,  Kaori Nishizawa ,  Fukue Nagata ,  Kohji Okada ,  Hiroshi Sumi

发明人： Yoshiyuki Yokogawa ,  Tetsuya Kameyama ,  Yukari Kawamoto ,  Kaori Nishizawa ,  Fukue Nagata ,  Kohji Okada ,  Hiroshi Sumi

IPC分类号： A61L27/00 ,  A61K6/033 ,  C01B25/32 ,  D06M11/71 ,  D06M11/72 ,  B05D1/38 ,  B05D1/18 ,  B05D3/02

CPC分类号： D06M11/71 ,  D06M11/72

摘要： The present invention provides a method for producing a calcium phosphate coating film on the surface of a substrate, even a substrate which has poor heat resistance. The method comprises the steps of soaking a substrate in a first solution containing phosphate ions, inter alia, aqueous solutions of a basic phosphate salt such as Na.sub.3 PO.sub.4 or Na.sub.2 HPO.sub.4 ; removing the substrate and drying it; and soaking the substrate in a second solution (aqueous solution) containing calcium ions, to thereby obtain a coating film comprising hydroxyapatite or a mixture containing hydroxyapatite and a hydroxyapatite precursor. The substrate removed from the second solution may be soaked in a third solution (aqueous solution) containing an apatite component at a substantially saturated or supersaturated concentration, to thereby form a hydroxyapatite coating film. There may be used substrates formed of metals, ceramics, organic polymer materials, etc. The method is applicable to a substrate having poor heat resistance, such as synthetic resin fabric, due to omission of high-temperature treatment.

摘要翻译： 本发明提供一种在基材表面即使是耐热性差的基材上生产磷酸钙涂膜的方法。 该方法包括以下步骤：将底物浸泡在含有磷酸根离子的第一溶液中，特别是碱性磷酸盐如Na 3 PO 4或Na 2 HPO 4的水溶液; 去除基底并干燥; 并将基材浸渍在含有钙离子的第二溶液（水溶液）中，从而得到包含羟基磷灰石或含羟基磷灰石和羟基磷灰石前体的混合物的涂膜。 从第二溶液中除去的基材可以浸渍在含有基本上饱和或过饱和浓度的磷灰石组分的第三溶液（水溶液）中，从而形成羟基磷灰石涂膜。 可以使用由金属，陶瓷，有机聚合物材料等形成的基材。由于省略了高温处理，该方法可应用于耐热性差的基材如合成树脂织物。