公开(公告)号：US20060246565A1

公开(公告)日：2006-11-02

申请号：US10541446

申请日：2004-01-09

申请人： Takahiro Ueda ,  Tadao Ohno ,  Shiro Kitamura

发明人： Takahiro Ueda ,  Tadao Ohno ,  Shiro Kitamura

IPC分类号： C12N9/00 ,  C07C43/02

CPC分类号： C07C41/36 ,  C07C43/23

摘要： The object of the present invention is to provide a method of purifying reduced coenzyme Q10 to produce a high-quality product which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc., by a efficient manner suitable for an industrial scale production. The present invention relates to a method of purifying reduced coenzyme Q10 which comprises washing crystals and/or oil of reduced coenzyme Q10 with a water-soluble organic solvent or a mixed solvent composed of a water-soluble organic solvent and water to thereby remove water-soluble impurities, especially a reducing agent or impurities derived from a reducing agent, from the crystals and/or oil of reduced coenzyme Q10. The present invention makes it possible to conveniently and efficiently purify reduced coenzyme Q1o in a manner excellent in operationality, and to obtain a high-quality reduced coenzyme Q10.

摘要翻译： 本发明的目的是提供一种纯化还原型辅酶Q 10的方法，以产生可用作食品，功能性营养食品，特定保健食品，营养补充剂中的成分的高品质产品 营养物质，动物药品，饮料，饲料，化妆品，药​​品，补救措施，预防药品等，以适合工业规模生产的有效方式。 本发明涉及一种纯化还原型辅酶Q 10的方法，该方法包括用水溶性有机溶剂或混合物洗涤还原型辅酶Q 10的晶体和/或油 溶剂由水溶性有机溶剂和水组成，从而从还原型辅酶Q 10的结晶和/或油中除去水溶性杂质，特别是还原剂或衍生自还原剂的杂质， 。 本发明使得可以以优异的操作性方式方便且有效地纯化还原型辅酶Q 1 O 3，并获得高质量的还原型辅酶Q 10。

公开(公告)号：US08568779B2

公开(公告)日：2013-10-29

申请号：US12522792

申请日：2008-01-10

申请人： Kento Kanaya ,  Shiro Kitamura ,  Takahiro Ueda

发明人： Kento Kanaya ,  Shiro Kitamura ,  Takahiro Ueda

IPC分类号： A61K9/16 ,  A61K31/122 ,  C07C46/10 ,  A61K9/107 ,  C07C50/28 ,  C09K15/08

CPC分类号： A61K31/122 ,  A23V2250/314 ,  A61K9/1075 ,  A61K9/141 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/1688 ,  C07C46/10 ,  C07C50/28 ,  C09K15/08

摘要： The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.

摘要翻译： 本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。 本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至 在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。 根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

公开(公告)号：US08067217B2

公开(公告)日：2011-11-29

申请号：US11315161

申请日：2005-12-23

申请人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

发明人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC分类号： C12N9/98

CPC分类号： A61K9/4816

摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.

摘要翻译： 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药​​物， 补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过 超过60％。 根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

公开(公告)号：US20110263906A1

公开(公告)日：2011-10-27

申请号：US13176479

申请日：2011-07-05

申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC分类号： C07C41/40

CPC分类号： C07C41/40 ,  C07C43/23

摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.

摘要翻译： 本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。 根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。 此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。 因此，可以高产率获得高纯度还原型辅酶Q10。

公开(公告)号：US20100234643A1

公开(公告)日：2010-09-16

申请号：US12740086

申请日：2008-10-29

申请人： Takahiro Ueda ,  Shiro Kitamura

发明人： Takahiro Ueda ,  Shiro Kitamura

IPC分类号： C07C45/41

CPC分类号： C07C41/26 ,  C07C41/40 ,  C07C43/23

摘要： The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.

摘要翻译： 本发明旨在提供可用作食物，具有营养功能要求的食物，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物，治疗药物，预防性药物的还原型辅酶Q10 药物等，以及还原型辅酶Q10的制造方法。 本发明提供还原型辅酶Q10的制造方法，该方法包括在不高于pH 5的含水有机溶剂中，用抗坏血酸或其类似物还原氧化型辅酶Q10作为还原剂。使用该方法， 即使没有添加碱性物质等，反应时间也可以大大缩短，并且不利的副反应可以最小化。 因此，可以生产具有高质量的还原型辅酶Q10。

公开(公告)号：US20080152636A1

公开(公告)日：2008-06-26

申请号：US11896976

申请日：2007-09-07

申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yoshiyuki Shinagawa ,  Taizou Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yoshiyuki Shinagawa ,  Taizou Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

IPC分类号： A61K8/35

CPC分类号： A23K20/10 ,  A23K20/158 ,  A23L33/10 ,  A61K8/347 ,  A61K8/553 ,  A61K9/08 ,  A61K31/122 ,  A61Q19/00

摘要： The present invention provides a method of improving the absorbability of reduced coenzyme Q10, which includes affording a composition containing lysolecithin and reduced coenzyme Q10 in combination. The composition containing lysolecithin and reduced coenzyme Q10 of the present invention shows superior absorption of reduced coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

摘要翻译： 本发明提供了提高还原型辅酶Q 10的吸收性的方法，其包括组合物提供含有溶血卵磷脂和还原型辅酶Q 10的组合物。 含有本发明的溶血卵磷脂和还原型辅酶Q 10的组合物显示出优异的还原型辅酶Q 10的吸收，并且可以用于食品，具有营养功能的食物，具体的食品 保健用品，营养补充剂，营养制品，动物药，饮料，饲料，宠物食品，化妆品，药​​品，治疗药物，预防药物等。

公开(公告)号：US20070161825A1

公开(公告)日：2007-07-12

申请号：US11716828

申请日：2007-03-12

申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC分类号： C07C43/20

CPC分类号： C07C41/26 ,  C07C41/34 ,  C07C43/23

摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

公开(公告)号：US09295656B2

公开(公告)日：2016-03-29

申请号：US11812887

申请日：2007-06-22

申请人： Takashi Ueda ,  Shinsuke Akao ,  Shiro Kitamura ,  Hideyuki Kishida ,  Takahiro Ueda

发明人： Takashi Ueda ,  Shinsuke Akao ,  Shiro Kitamura ,  Hideyuki Kishida ,  Takahiro Ueda

IPC分类号： A61K31/122 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/107

CPC分类号： C07C50/28 ,  A61K9/0056 ,  A61K9/107 ,  A61K9/1652 ,  A61K9/1664 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/4875 ,  A61K31/122

摘要： The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.

摘要翻译： 本发明提供了一种颗粒组合物，其中含有还原型辅酶Q10的油成分是多分散的，在含有水溶性赋形剂的基质中形成一个结构域，其同时表现出高氧化稳定性和高口服吸收性，其制备方法和稳定化方法 其中。 它还提供食物，具有营养功能的食物，特定健康用途的食物，膳食补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药​​物，治疗药物，预防药物等，其含有 组成。

公开(公告)号：US08703155B2

公开(公告)日：2014-04-22

申请号：US10492122

申请日：2002-10-10

申请人： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

发明人： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC分类号： A61K38/43 ,  A61K9/00

CPC分类号： A61K31/122 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  B01D9/00 ,  C07C41/26 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

摘要： The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10, in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.

摘要翻译： 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制的条件下，可以处理和稳定地保持还原型辅酶Q10，从而得到稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化，使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的还原型辅酶Q10晶体。 此外，通过使生成的还原型辅酶Q10连续结晶，在使用抗坏血酸或其相关化合物还原氧化型辅酶Q10至还原型辅酶Q10后，在抗坏血酸或其相关化合物的存在下，操作简化并最小化，从而减少了辅酶Q10 生产高品质。

公开(公告)号：US20070258966A1

公开(公告)日：2007-11-08

申请号：US11741290

申请日：2007-04-27

申请人： Takahiro UEDA ,  Shiro Kitamura ,  Hiroshi Kubo ,  Kazunori Hosoe

发明人： Takahiro UEDA ,  Shiro Kitamura ,  Hiroshi Kubo ,  Kazunori Hosoe

IPC分类号： A61K38/43 ,  C07C39/10

CPC分类号： A61K31/047 ,  A61K9/4858

摘要： The present invention provides a method for stabilizing reduced coenzyme Q10, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like. The present invention also provides a method of producing a reduced coenzyme Q10-containing composition which includes the co-presence of reduced coenzyme Q10 and reduced coenzyme Q9 and/or reduced coenzyme Q11.

摘要翻译： 本发明提供了用于稳定还原型辅酶Q 10的方法，其可用作食品，营养产品，营养补充剂，动物药物，饮料，饲料，化妆品，药​​物产品，治疗药物，预防药物 等等。 本发明还提供一种制备还原型辅酶Q 10系组合物的方法，该组合物包括还原型辅酶Q 10和还原型辅酶Q 9的共存 和/或还原型辅酶Q 11。