公开(公告)号：US4243812A

公开(公告)日：1981-01-06

申请号：US67889

申请日：1979-08-20

申请人： Takaji Honna ,  Motoaki Tanaka ,  Syozo Yamada ,  Hidekazu Miyake

发明人： Takaji Honna ,  Motoaki Tanaka ,  Syozo Yamada ,  Hidekazu Miyake

IPC分类号： A61K31/42 ,  A61P25/04 ,  A61P29/00 ,  C07D261/08 ,  C07D261/12

CPC分类号： C07D261/08

摘要： Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrate. They have anti-inflammatory and/or analgesic activities.

摘要翻译： 根据本发明提供了由化学式 [I]表示的乙二醛-2-肟基的新型衍生物，其中R是氢或低级烷基或苯基。 这些衍生物通过在金属醇盐或相应的5-乙酰异恶唑与硝酸盐存在下使相应的异恶唑-5-甲醛与硝基甲烷反应来制备。 它们具有抗炎和/或止痛活性。

公开(公告)号：US4224450A

公开(公告)日：1980-09-23

申请号：US67888

申请日：1979-08-20

申请人： Takaji Honna ,  Motoaki Tanaka ,  Syozo Yamada ,  Hidekazu Miyake

发明人： Takaji Honna ,  Motoaki Tanaka ,  Syozo Yamada ,  Hidekazu Miyake

IPC分类号： A61K31/42 ,  A61P25/04 ,  A61P29/00 ,  C07D261/08 ,  C07D261/14

CPC分类号： C07D261/08

摘要： Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.

摘要翻译： 根据本发明提供了由化学式 [I]表示的乙二醛-2-肟基的新型衍生物，其中R是氢或低级烷基或苯基。 这些衍生物通过在金属醇盐或相应的5-乙酰异恶唑与亚硝酸盐存在下使相应的异恶唑-5-甲醛与硝基甲烷反应来制备。 它们具有抗炎和/或止痛活性。

公开(公告)号：US4212874A

公开(公告)日：1980-07-15

申请号：US16821

申请日：1979-03-02

申请人： Takaji Honna ,  Motoaki Tanaka ,  Syozo Yamada ,  Hidekazu Miyake

发明人： Takaji Honna ,  Motoaki Tanaka ,  Syozo Yamada ,  Hidekazu Miyake

IPC分类号： A61K31/42 ,  A61P25/04 ,  A61P29/00 ,  C07D261/08

CPC分类号： C07D261/08

摘要： Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.

摘要翻译： 根据本发明提供了由化学式 [I]表示的乙二醛-2-肟基的新型衍生物，其中R是氢或低级烷基或苯基。 这些衍生物通过在金属醇盐或相应的5-乙酰异恶唑与亚硝酸盐存在下使相应的异恶唑-5-甲醛与硝基甲烷反应来制备。 它们具有抗炎和/或止痛活性。

公开(公告)号：US4443607A

公开(公告)日：1984-04-17

申请号：US361935

申请日：1982-03-25

申请人： Shigeo Senda ,  Osamu Ohtani ,  Eiichi Katho ,  Mitsuaki Nagasaka ,  Hidekazu Miyake ,  Khosuke Fujiwara ,  Motoaki Tanaka

发明人： Shigeo Senda ,  Osamu Ohtani ,  Eiichi Katho ,  Mitsuaki Nagasaka ,  Hidekazu Miyake ,  Khosuke Fujiwara ,  Motoaki Tanaka

IPC分类号： C07D217/24

CPC分类号： C07D217/24

摘要： Novel 1(2H)-isoquinolone compounds and the acid addition salts thereof are disclosed. These compounds are useful as pharmaceutical agents in view of their anti-ulcer, stomach mucous membrane blood flow increasing, anti-hypertensive, analgesic, anti-histamine, anti-cholinergic and gastric secretion inhibitory activities.

摘要翻译： 公开了新的1（2H） - 异喹诺酮化合物及其酸加成盐。 考虑到它们的抗溃疡，胃粘膜血流量增加，抗高血压，止痛，抗组胺，抗胆碱能和胃分泌抑制活性，这些化合物可用作药剂。

公开(公告)号：US4895941A

公开(公告)日：1990-01-23

申请号：US316631

申请日：1989-02-28

申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai

IPC分类号： C07D499/87 ,  C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/86 ,  C07D499/861 ,  C07D499/897

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： 2.alpha.-Methyl-2.beta.-(1,2,3-triazol-1-yl)methylpenam-3.alpha.-carboxylic acid derivatives are prepared by reacting a penicillanic acid sulfoxide derivative of the formula ##STR1## wherein R is a penicillin carboxyl protecting group, and R.sub.1 is hydrogen or halogen, R.sub.2 is hydrogen, lower alkyl or the like with a triazole derivative of the formula ##STR2## wherein R.sub.3 and R.sub.4 are hydrogen, trialkylsilyl, lower alkyl, lower alkoxy or the like and R.sub.5 is hydrogen or silyl substituted with 3 groups selected from the class consisting of lower alkyl, benzyl and phenyl in a solvent.

公开(公告)号：US4826959A

公开(公告)日：1989-05-02

申请号：US150264

申请日：1988-01-29

申请人： Motoaki Tanaka ,  Tsutomu Miyagawa ,  Hideo Takeuchi

发明人： Motoaki Tanaka ,  Tsutomu Miyagawa ,  Hideo Takeuchi

IPC分类号： C07C67/00 ,  C07C253/00 ,  C07C255/04 ,  C07C255/65 ,  C08F4/04 ,  C08J9/06 ,  C08J9/10 ,  C07C107/00 ,  C07C107/02 ,  C07C107/04

CPC分类号： C07C255/65 ,  C08F4/04 ,  C08J9/102 ,  Y10S534/01

摘要： A mixture of an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a low melting point in an amount of about 70% by weight or more and an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a high melting point in an amount of about 30% by weight or less shows excellent solvent solubility, which is higher than that of the isomer having a low melting point. The mixture is useful as a polymerization initiator, and also as a blowing agent.

摘要翻译： 具有约70重量％以上的低熔点的2,2'-偶氮双（2,4-二甲基戊腈）的异构体和2,2'-偶氮双（2,4-二氯苯基） 具有约30重量％以下的高熔点的二甲基戊腈表现出优异的溶剂溶解度，其高于具有低熔点的异构体的溶解度。 该混合物可用作聚合引发剂，也可用作发泡剂。

公开(公告)号：US4777251A

公开(公告)日：1988-10-11

申请号：US43047

申请日：1987-04-27

申请人： Motoaki Tanaka ,  Tutomu Miyagawa ,  Iwao Takagishi

发明人： Motoaki Tanaka ,  Tutomu Miyagawa ,  Iwao Takagishi

IPC分类号： C09B47/067 ,  C09B67/50

CPC分类号： C09B67/0026 ,  C09B47/067

摘要： An improved process for preparing oxytitanium phthalocyanine is provided wherein the condensation reaction of o-phthalodinitrile with titanium tetrachloride is effected in an organic solvent at 170.degree. to 300.degree. C. followed by hydrolysis, the improvement wherein said organic solvent is preliminarily heated at a temperature of 160.degree. to 300.degree. C. prior to initiation of the condensation reaction. The A form of oxytitanium phthalocyanine crystal can selectively be produced in the pure state.

摘要翻译： 提供了一种制备氧钛酞菁的改进方法，其中邻苯二甲腈与四氯化钛的缩合反应在有机溶剂中在170℃至300℃下进行，然后进行水解，其改进在于所述有机溶剂在温度 在开始缩合反应之前为160℃至300℃。 氧化钛酞菁晶体的A形式可以选择性地以纯态生产。

公开(公告)号：US4399213A

公开(公告)日：1983-08-16

申请号：US312136

申请日：1981-10-16

申请人： Yoshikazu Watanabe ,  Motoaki Tanaka

发明人： Yoshikazu Watanabe ,  Motoaki Tanaka

IPC分类号： G03C1/32 ,  G03C1/38 ,  G03C1/76 ,  G03C1/78

CPC分类号： G03C1/7614 ,  G03C1/32 ,  G03C1/385 ,  Y10S430/142 ,  Y10S430/151

摘要： A silver halide photosensitive material comprising a support, a silver halide photosensitive layer, and a protective layer formed on said support. The protective layer is essentially composed on a plurality of non-photosensitive hydrophilic colloidal layers at least one of which contains oil particles. The outermost layer of the hydrophilic colloidal layers contains a matting agent in the form of colloidal particles and has a thickness of not more than one fourth of the average size of the matting agent particles and wherein the density of the oil particles in said outermost layer does not exceed 0.2 by volume of the binder, and that of the oil particles in the protective layers other than the outermost layer is in the range of 0.1 to 0.8.

摘要翻译： 一种卤化银感光材料，其包括载体，卤化银感光层和形成在所述载体上的保护层。 保护层基本上由多个非感光亲水性胶体层构成，其中至少一个含有油颗粒。 亲水性胶体层的最外层含有胶体颗粒形式的消光剂，其厚度不超过消光剂颗粒的平均尺寸的四分之一，其中所述最外层中的油颗粒的密度为 不超过粘合剂体积的0.2体积，除了最外层以外的保护层中的油粒子的比例在0.1〜0.8的范围内。

公开(公告)号：US08058261B2

公开(公告)日：2011-11-15

申请号：US12375077

申请日：2007-07-23

申请人： Motoaki Tanaka ,  Masakazu Fukushima

发明人： Motoaki Tanaka ,  Masakazu Fukushima

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： C07H19/06

摘要： To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug.The invention provides a 3′-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.

摘要翻译： 提供表现出优异的抗肿瘤活性和优异的口服吸收并且是有用的抗肿瘤药物的化合物。 本发明提供由式（1）表示的3'-乙炔基胞苷衍生物：其中X表示（取代）烷基羰基，（取代）烷氧基羰基或氢原子; Y和Z之一表示氢原子或 （R 1）（R 2）（R 3）Si表示的基团，另一个表示由（R 4）（R 5）（R 6）Si - 表示的基团，R 1，R 2，R 3，R 4，R 5和R 6各自表示 （取代的）烷基，（取代的）环烷基或（取代的）芳基）或其盐。

公开(公告)号：US20090306008A1

公开(公告)日：2009-12-10

申请号：US12375077

申请日：2007-07-23

申请人： Motoaki Tanaka ,  Masakazu Fukushima

发明人： Motoaki Tanaka ,  Masakazu Fukushima

IPC分类号： A61K31/7068 ,  C07H19/067 ,  A61P35/00

CPC分类号： C07H19/06

摘要： To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug.The invention provides a 3′-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.

摘要翻译： 提供表现出优异的抗肿瘤活性和优异的口服吸收并且是有用的抗肿瘤药物的化合物。 本发明提供由式（1）表示的3'-乙炔基胞苷衍生物：其中X表示（取代）烷基羰基，（取代）烷氧基羰基或氢原子; Y和Z之一表示氢原子或 （R 1）（R 2）（R 3）Si表示的基团，另一个表示由（R 4）（R 5）（R 6）Si - 表示的基团，R 1，R 2，R 3，R 4，R 5和R 6各自表示 （取代的）烷基，（取代的）环烷基或（取代的）芳基）或其盐。