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公开(公告)号：US07345126B2
公开(公告)日：2008-03-18
申请号：US11194722
申请日：2005-08-01
IPC分类号： C08F118/02 , C08G69/137
CPC分类号： C08F220/26 , C08F8/00 , C08F220/00
摘要： The present invention provides a production method of a hydroxyl-containing polymer including: protecting a hydroxyl group of a hydroxyl-containing monomer with a protecting group to make the monomer a protected monomer with decreased hydrophilicity; adding the protected monomer alone or together with a hydrophobic monomer to a water-based medium containing a salt and a dispersion stabilizer; adding a polymerization initiator to the mixture to carry out suspension polymerization; and de-protecting the obtained polymer having the protecting group to recover the hydroxyl group.
摘要翻译： 本发明提供含羟基聚合物的制备方法，包括：用保护基保护含羟基单体的羟基，使单体成为亲水性降低的被保护单体; 将保护的单体单独或与疏水单体一起加入到含有盐和分散稳定剂的水性介质中; 向混合物中加入聚合引发剂进行悬浮聚合; 并将所得到的具有保护基的聚合物去保护以回收羟基。
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公开(公告)号：US20060128943A1
公开(公告)日：2006-06-15
申请号：US11129851
申请日：2005-05-16
CPC分类号： C07K1/1077
摘要： The invention provides a maleimidyl-containing material having a substituent group defined by the following structural formula (1) containing a maleimidyl group (maleimido group): wherein A denotes a spacer containing an amino acid or a peptide spacer P. Also, the invention provides a production method of the above-mentioned maleimidyl-containing material involving a step of reacting a material containing an amino acid or a peptide chain with a compound containing a maleimido group.
摘要翻译： 本发明提供具有由以下结构式（1）定义的含有马来酰亚胺基（马来酰亚胺基）的取代基的含马来酰亚胺基的物质：其中A表示含有氨基酸或肽间隔物P的间隔物。另外，本发明提供 上述含有马来酰亚胺基的材料的制备方法包括使含有氨基酸或肽链的材料与含有马来酰亚胺基的化合物反应的步骤。
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3.发明授权公开(公告)号：US07442553B2
公开(公告)日：2008-10-28
申请号：US11052923
申请日：2005-02-09
IPC分类号： G01N33/44 , G01N33/545
CPC分类号： C08F8/34 , C08F8/30 , C08F2800/20 , C08F2810/20 , G01N15/1459 , G01N21/6428 , G01N21/77 , G01N33/442 , G01N2015/149 , G01N2021/7786 , Y10T436/17 , Y10T436/20 , C08F8/14 , C08F2220/1858
摘要： A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to react with the maleimidyl groups and determining the amount of maleimidyl groups by means of measuring the fluorescence of the fluorescent material.
摘要翻译： 通过使具有SH基团的荧光体与马来酰亚胺基反应并通过测定马来酰亚胺基的量来测定马来酰亚胺基的量，定量测定含有至少马来酰亚胺基的聚合物微粒上的马来酰亚胺基的量的方法 荧光材料。
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公开(公告)号：US20060069213A1
公开(公告)日：2006-03-30
申请号：US11057159
申请日：2005-02-15
IPC分类号： C08F20/10
CPC分类号： C08F220/18 , B01J20/26 , B01J20/261 , B01J20/265 , B01J20/285 , C08F212/08 , C08F220/36 , C08F2220/285
摘要： A polymer comprising a styrene-based monomer and t-butyl methacrylate, wherein a proportion of the styrene-based monomer in the polymer is 30% by mol to 90% by mol and the polymer has a functional group represented by the following formula (1) which includes a maleimidyl group: wherein in the formula (1), X represents —O— or —NH— and Q represents a spacer group. A ligand immobilization support comprising the polymer.
摘要翻译： 一种包含苯乙烯基单体和甲基丙烯酸叔丁酯的聚合物，其中所述聚合物中苯乙烯类单体的比例为30摩尔％至90摩尔％，并且所述聚合物具有由下式（1 ），其包括马来酰亚胺基：
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公开(公告)号：US07399816B2
公开(公告)日：2008-07-15
申请号：US11129851
申请日：2005-05-16
IPC分类号： C08F26/02
CPC分类号： C07K1/1077
摘要： The invention provides a maleimidyl-containing material having a substituent group defined by the following structural formula (1) containing a maleimidyl group (maleimido group): wherein A denotes a spacer containing an amino acid or a peptide spacer P. Also, the invention provides a production method of the above-mentioned maleimidyl-containing material involving a step of reacting a material containing an amino acid or a peptide chain with a compound containing a maleimido group.
摘要翻译： 本发明提供具有由以下结构式（1）定义的含有马来酰亚胺基（马来酰亚胺基）的取代基的含马来酰亚胺基的物质：其中A表示含有氨基酸或肽间隔物P的间隔物。另外，本发明提供 上述含有马来酰亚胺基的材料的制备方法包括使含有氨基酸或肽链的材料与含有马来酰亚胺基的化合物反应的步骤。
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公开(公告)号：US07317059B2
公开(公告)日：2008-01-08
申请号：US11057159
申请日：2005-02-15
IPC分类号： C08F26/06
CPC分类号： C08F220/18 , B01J20/26 , B01J20/261 , B01J20/265 , B01J20/285 , C08F212/08 , C08F220/36 , C08F2220/285
摘要： A polymer comprising a styrene-based monomer and t-butyl methacrylate, wherein a proportion of the styrene-based monomer in the polymer is 30% by mol to 90% by mol and the polymer has a functional group represented by the following formula (1) which includes a maleimidyl group: wherein in the formula (1), X represents —O— or —NH— and Q represents a spacer group. A ligand immobilization support comprising the polymer.
摘要翻译： 一种包含苯乙烯基单体和甲基丙烯酸叔丁酯的聚合物，其中所述聚合物中苯乙烯类单体的比例为30摩尔％至90摩尔％，并且所述聚合物具有由下式（1 ），其中包括马来酰亚胺基：其中在式（1）中，X表示-O-或-NH-，Q表示间隔基。 包含聚合物的配体固定载体。
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公开(公告)号：US20060205905A1
公开(公告)日：2006-09-14
申请号：US11194722
申请日：2005-08-01
IPC分类号： C08F118/02
CPC分类号： C08F220/26 , C08F8/00 , C08F220/00
摘要： The present invention provides a production method of a hydroxyl-containing polymer including: protecting a hydroxyl group of a hydroxyl-containing monomer with a protecting group to make the monomer a protected monomer with decreased hydrophilicity; adding the protected monomer alone or together with a hydrophobic monomer to a water-based medium containing a salt and a dispersion stabilizer; adding a polymerization initiator to the mixture to carry out suspension polymerization; and de-protecting the obtained polymer having the protecting group to recover the hydroxyl group.
摘要翻译： 本发明提供含羟基聚合物的制备方法，包括：用保护基保护含羟基单体的羟基，使单体成为亲水性降低的被保护单体; 将保护的单体单独或与疏水单体一起加入到含有盐和分散稳定剂的水性介质中; 向混合物中加入聚合引发剂进行悬浮聚合; 并将所得到的具有保护基的聚合物去保护以回收羟基。
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8.发明申请公开(公告)号：US20060051871A1
公开(公告)日：2006-03-09
申请号：US11052923
申请日：2005-02-09
IPC分类号： G01N33/44
CPC分类号： C08F8/34 , C08F8/30 , C08F2800/20 , C08F2810/20 , G01N15/1459 , G01N21/6428 , G01N21/77 , G01N33/442 , G01N2015/149 , G01N2021/7786 , Y10T436/17 , Y10T436/20 , C08F8/14 , C08F2220/1858
摘要： A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to react with the maleimidyl groups and determining the amount of maleimidyl groups by means of measuring the fluorescence of the fluorescent material.
摘要翻译： 通过使具有SH基团的荧光体与马来酰亚胺基反应并通过测定马来酰亚胺基的量来测定马来酰亚胺基的量，定量测定含有至少马来酰亚胺基的聚合物微粒上的马来酰亚胺基的量的方法 荧光材料。
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9.发明申请Maleimide group-containing polymer particles and method of producing the same 失效含有马来酰亚胺基团的聚合物粒子及其制造方法公开(公告)号：US20050014924A1
公开(公告)日：2005-01-20
申请号：US10780742
申请日：2004-02-19
申请人： Yoshihiro Inaba , Chisato Urano , Takako Kobayashi
发明人： Yoshihiro Inaba , Chisato Urano , Takako Kobayashi
CPC分类号： C08F8/30 , C08F2810/20 , C08F2810/30 , C08F2810/40 , C08F220/18 , C08F212/36 , C08F8/00
摘要： The present invention relates to a maleimide group-containing polymer particle containing a crosslinked polymer particle containing a group represented by the following formula (1) and to a method of producing the maleimide group-containing crosslinked polymer particle by reacting hydroxymethylmaleimide with a hydroxyl group-containing polymer particle obtained by introducing a polyethylene glycol into a crosslinked polymer particle: wherein n denotes an integer of 1 or more.
摘要翻译： 本发明涉及含有含有下式（1）表示的基团的交联聚合物粒子的含马来酰亚胺基团的聚合物粒子以及羟基甲基马来酰亚胺与羟基 - 甲基马来酰亚胺反应的制备含马来酰亚胺基团的交联聚合物粒子的方法， 通过将聚乙二醇引入到交联聚合物颗粒中而获得的含聚合物颗粒：其中n表示1以上的整数。
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公开(公告)号：US06914100B2
公开(公告)日：2005-07-05
申请号：US10390004
申请日：2003-03-18
IPC分类号： C08J3/12 , C08F8/32 , C08F220/34 , C08F246/00 , C08G73/10
CPC分类号： C08F246/00 , C08F8/32 , C08G73/1092
摘要： A crosslinked polymer particle can be obtained by carrying out a crosslinking reaction between a non-crosslinked polymer particle containing a succinimidoxycarbonyl group and a compound having two or more amino groups.
摘要翻译： 通过在含有琥珀酰亚胺氧基羰基的非交联聚合物粒子和具有两个以上氨基的化合物之间进行交联反应，可以得到交联聚合物粒子。
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