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11 条记录 (耗时 0.066 秒)

    Heterocyclic compound
    8.
    发明授权
    Heterocyclic compound 有权
    杂环化合物

    公开(公告)号：US09156837B2

    公开(公告)日：2015-10-13

    申请号：US14235992

    申请日：2012-07-27

    申请人： Satoshi Yamamoto ,  Junya Shirai ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Yoshihide Tomata ,  Ayumu Sato ,  Shotaro Miura ,  Kazuko Yonemori ,  Ryokichi Koyama

    发明人： Satoshi Yamamoto ,  Junya Shirai ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Yoshihide Tomata ,  Ayumu Sato ,  Shotaro Miura ,  Kazuko Yonemori ,  Ryokichi Koyama

    IPC分类号： C07D277/30 ,  C07D277/56 ,  C07D211/90 ,  C07D417/12 ,  C07D471/04 ,  C07D401/12 ,  C07D277/24 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107

    CPC分类号： C07D471/04 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107

    摘要： A heterocyclic compound having an RORγt inhibitory activity, which is a compound of formula (I) or a salt thereof is provided. The compound has ring A, which is an optionally substituted cyclic group and is bound to a pyrazole ring though Q. Q is a bond, optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene. R1 is a substituent. Ring B is a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which is optionally further substituted by a substituent in addition to R2. R2 is an optionally substituted cyclyl-carbonyl-C1-6 alkyl group, an optionally substituted aminocarbonyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkylamino-carbonyl group, an optionally substituted aminocarbonyl-C2-6 alkenyl group, an optionally substituted C1-6 alkylcarbonylamino-C1-6 alkyl group, an optionally substituted cyclyl-aminocarbonyl group, an optionally substituted cyclyl-carbonyl group or an optionally substituted non-aromatic heterocyclic group.

    摘要翻译： 提供具有RORγt抑制活性的杂环化合物，其为式（I）化合物或其盐。 该化合物具有环A，其为任选取代的环状基团，并且通过Q键合至吡唑环。Q为键，任选取代的C 1-10亚烷基，任选取代的C 2-10亚烯基或任选取代的C 2-10亚炔基。 R1是取代基。 环B是噻唑环，异噻唑环或二氢噻唑环，除了R2之外，它们各自任选进一步被取代基取代。 R 2是任选取代的环羰基-C 1-6烷基，任选取代的氨基羰基-C 1-6烷基，任选取代的环C 1-6烷基，任选取代的环C 1-6烷基氨基羰基， 任选取代的氨基羰基-C 2-6烯基，任选取代的C 1-6烷基羰基氨基-C 1-6烷基，任选取代的环 - 氨基羰基，任选取代的环羰基或任选取代的非芳族杂环基。

    Triazole derivative and use thereof
    9.
    发明授权
    Triazole derivative and use thereof 失效
    三唑衍生物及其用途

    公开(公告)号：US07803822B2

    公开(公告)日：2010-09-28

    申请号：US11887936

    申请日：2006-04-06

    申请人： Keiji Kubo ,  Mamoru Tobisu ,  Eiji Honda ,  Takahiko Taniguchi ,  Yoshiyuki Fukase ,  Masaki Kawamura ,  Masaharu Nakayama

    发明人： Keiji Kubo ,  Mamoru Tobisu ,  Eiji Honda ,  Takahiko Taniguchi ,  Yoshiyuki Fukase ,  Masaki Kawamura ,  Masaharu Nakayama

    IPC分类号： A61K31/41 ,  C07D249/00

    CPC分类号： C07D249/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D411/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

    摘要： The present invention relates to a thrombin receptor antagonist containing a compound represented by the formula (I) wherein R1a, R1b and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted alkoxy, R3 is a group represented by the formula —NHCOR4, —NHSO2R5, —NHCON(R6a)(R6b), —NHCOOR7 or —CONHR8 wherein R4, R5, R6a, R6b, R7 and R8 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like), ring A is monocyclic aromatic ring optionally further having substituent(s), R1a and R1b are optionally bonded to each other to form an optionally substituted nitrogen-containing non-aromatic heterocycle, or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the present invention has a thrombin receptor (particularly PAR-1) antagonistic action and is useful for the prophylaxis or treatment of PAR-1 mediated pathological condition or disease.

    摘要翻译： 本发明涉及含有式（I）表示的化合物的凝血酶受体拮抗剂，其中R1a，R1b和R2各自为氢原子，任选取代的烃基，任选取代的杂环基或任选取代的烷氧基，R 3 是由式-NHCOR4，-NHSO2R5，-NHCON（R6a）（R6b），-NHCOOR7或-CONHR8表示的基团，其中R4，R5，R6a，R6b，R7和R8各自为氢原子，任选取代的烃基 ，任选取代的杂环基等），环A是任选进一步具有取代基的单环芳环，R 1a和R 1b任选地彼此键合以形成任选取代的含氮非芳族杂环或盐 或其前药。 本发明的凝血酶受体拮抗剂具有凝血酶受体（特别是PAR-1）拮抗作用，可用于预防或治疗PAR-1介导的病理状态或疾病。

    HETEROCYCLIC COMPOUND
    10.
    发明申请
    HETEROCYCLIC COMPOUND 有权
    杂环化合物

    公开(公告)号：US20140163001A1

    公开(公告)日：2014-06-12

    申请号：US14235992

    申请日：2012-07-27

    申请人： Satoshi Yamamoto ,  Junya Shirai ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Yoshihide Tomata ,  Ayumu Sato ,  Shotaro Miura ,  Kazuko Yonemori ,  Ryokichi Koyama

    发明人： Satoshi Yamamoto ,  Junya Shirai ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Yoshihide Tomata ,  Ayumu Sato ,  Shotaro Miura ,  Kazuko Yonemori ,  Ryokichi Koyama

    IPC分类号： C07D491/107 ,  C07D417/04 ,  C07D471/04 ,  C07D417/14

    CPC分类号： C07D471/04 ,  C07D417/04 ,  C07D417/14 ,  C07D491/107

    摘要： Provided is a heterocyclic compound having an RORγt inhibitory activity. A compound represented by the formula (I): wherein ring A is an optionally substituted cyclic group, Q is a bond, optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene, R1 is a substituent, ring B is a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which is optionally further substituted by a substituent in addition to R2, and R2 is an optionally substituted cyclyl-carbonyl-C1-6 alkyl group, an optionally substituted aminocarbonyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkylamino-carbonyl group, an optionally substituted aminocarbonyl-C2-6 alkenyl group, an optionally substituted C1-6 alkylcarbonylamino-C1-6 alkyl group, an optionally substituted cyclyl-aminocarbonyl group, an optionally substituted cyclyl-carbonyl group or an optionally substituted non-aromatic heterocyclic group, or a salt thereof.

    摘要翻译： 提供具有RORγt抑制活性的杂环化合物。 由式（I）表示的化合物：其中环A是任选取代的环状基团，Q是键，任选取代的C 1-10亚烷基，任选取代的C 2-10亚烯基或任选取代的C 2-10亚炔基，R 1是 取代基，环B是噻唑环，异噻唑环或二氢噻唑环，其中R 2独立地任选被取代基任意地进一步被R 2取代，R 2是任选取代的环羰基-C 1-6烷基，任选地 取代的氨基羰基-C 1-6烷基，任选取代的环烷基-C 1-6烷基，任选取代的环基-C 1-6烷基氨基 - 羰基，任选取代的氨基羰基-C 2-6链烯基，任选取代的C 1-6 烷基羰基氨基-C 1-6烷基，任选取代的环 - 氨基羰基，任选取代的环羰基或任选取代的非芳族杂环基，或其盐。