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    3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE
    1.
    发明申请
    3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE 审中-公开
    3 ARYL或HETEROARYL取代的INDOLE DERIVATIVE

    公开(公告)号：US20120028990A1

    公开(公告)日：2012-02-02

    申请号：US13260746

    申请日：2010-04-14

    申请人： Takashi Fujimura ,  Hiroyuki Kishino ,  Takashi Mizutani ,  Shunji Sakuraba ,  Takahide Sasaki ,  Nagaaki Sato

    发明人： Takashi Fujimura ,  Hiroyuki Kishino ,  Takashi Mizutani ,  Shunji Sakuraba ,  Takahide Sasaki ,  Nagaaki Sato

    IPC分类号： A61K31/404 ,  A61K31/4439 ,  A61K31/4725 ,  A61P3/04 ,  C07D403/12 ,  A61K31/496 ,  C07D417/14 ,  C07D409/14 ,  C07D405/14 ,  A61K31/454

    CPC分类号： C07D405/04 ,  C07D209/18 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04

    摘要： A 3-aryl or heteroaryl-substituted indole derivative which is effective as a preventive or remedy for various diseases is provided. [Means for Resolution] A compound represented by a formula (I) or a pharmaceutically acceptable salt thereof is provided. In the formula, R1 represents a hydrogen atom, C1-6 alkyl et al; R2 represents a hydrogen atom, C1-6 alkyl et al; Z represents aryl or heteroaryl (with the proviso that imidazolyl is excluded); and W represents a group represented by the formula (w-1) or (w-2). In the formula, R3 represents C1-6 alkyl et al; Yl and Y2 both represent a hydrogen atom or Y1 and Y2 together form —CH2-CH2-; Q represents CH or N; Ar represents phenyl, furyl et al; R4 and R5 each independently represent a hydrogen atom or C1-6 alkyl or R4 and R5 together with the nitrogen atom form pyrrolidine et al.

    摘要翻译： 提供作为各种疾病的预防或治疗有效的3-芳基或杂芳基取代的吲哚衍生物。 [解决方法]提供由式（I）表示的化合物或其药学上可接受的盐。 在该式中，R 1表示氢原子，C 1-6烷基等; R2表示氢原子，C1-6烷基等; Z表示芳基或杂芳基（条件是不包括咪唑基）; W表示由式（w-1）或（w-2）表示的基团。 在该式中，R 3表示C 1-6烷基等; Y 1和Y 2均表示氢原子或Y 1和Y 2一起形成-CH 2 -CH 2 - ; Q表示CH或N; Ar表示苯基，呋喃基等; R4和R5各自独立地表示氢原子或C1-6烷基或R4和R5以及氮原子形成吡咯烷等。

    Benzoxathiin derivative
    2.
    发明授权
    Benzoxathiin derivative 失效
    苯并硫堇衍生物

    公开(公告)号：US08163770B2

    公开(公告)日：2012-04-24

    申请号：US12084017

    申请日：2006-10-25

    申请人： Takashi Mizutani ,  Nagaaki Sato ,  Takahide Sasaki ,  Toshiyuki Takahashi

    发明人： Takashi Mizutani ,  Nagaaki Sato ,  Takahide Sasaki ,  Toshiyuki Takahashi

    IPC分类号： C07D513/02 ,  C07D515/02 ,  C07D211/22 ,  C07D327/06 ,  A01N43/42 ,  A01N43/40 ,  A61K31/44 ,  A61K31/445

    CPC分类号： C07D327/06 ,  C07D497/04

    摘要： Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.

    摘要翻译： 公开了由下式（I）表示的化合物及其药学上可接受的盐。 该化合物可用于治疗肥胖症，糖尿病等。 [式（I）中，Ar表示苯环等， X1表示氮原子，硫原子等; R1表示芳基等; X2表示由下式（II）表示的基团：（其中R4和R5分别表示低级烷基等，m表示2-4的数）等; X和Y中的一个表示氧原子，另一个表示硫烷基等; X3-X6分别表示-CH-，氮原子等。

    3-substituted sulfonyl piperidine derivative
    5.
    发明授权
    3-substituted sulfonyl piperidine derivative 有权
    3-取代的磺酰哌啶衍生物

    公开(公告)号：US08367698B2

    公开(公告)日：2013-02-05

    申请号：US13478680

    申请日：2012-05-23

    申请人： Tsuyoshi Nagase ,  Takahide Sasaki ,  Toshiyuki Takahashi

    发明人： Tsuyoshi Nagase ,  Takahide Sasaki ,  Toshiyuki Takahashi

    IPC分类号： A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/454 ,  C07D471/08 ,  C07D401/12 ,  C07D211/96

    CPC分类号： C07D211/26 ,  C07D401/04 ,  C07D401/14 ,  C07D453/06

    摘要： [Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease.[Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I) wherein Z represents wherein n1, n2, and n3 are 0, 1, or 2, respectively; R1 represents C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 represents aryl or heteroaryl; R3 represents a hydrogen atom, C1-6 alkyl, or the like; and M1, M2, M3, and M4 independently represent a hydrogen atom, C1-6 alkyl, or the like, or M1, together with M2, M3, or M4, forms —CH2— or the like.

    摘要翻译： [问题]提供了用作心血管疾病，神经疾病，代谢疾病，生殖疾病和消化疾病的预防或补救的化合物。 [解决方法]由下式（I）表示的化合物或其药学上可接受的盐，其中Z表示其中n1，n2和n3分别为0,1或2; R 1表示C 1-6烷基，C 3-8环烷基等; R2表示芳基或杂芳基; R3表示氢原子，C1-6烷基等; 并且M1，M2，M3和M4独立地表示氢原子，C1-6烷基等，或M1与M2，M3或M4一起形成-CH 2 - 等。

    4-SULFONYLPIPERIDINE DERIVATIVES
    6.
    发明申请
    4-SULFONYLPIPERIDINE DERIVATIVES 有权
    4-磺酰哌啶衍生物

    公开(公告)号：US20100234392A1

    公开(公告)日：2010-09-16

    申请号：US12674999

    申请日：2008-09-12

    申请人： Tsuyoshi Nagase ,  Takahide Sasaki ,  Toshiyuki Takahashi

    发明人： Tsuyoshi Nagase ,  Takahide Sasaki ,  Toshiyuki Takahashi

    IPC分类号： A61K31/46 ,  C07D241/04 ,  C07D451/02 ,  A61K31/4965 ,  A61K31/445 ,  A61K31/506 ,  A61P3/04

    CPC分类号： C07D451/04 ,  C07D487/08

    摘要： [Problems] To provide compounds useful as preventives or remedies for circulatory diseases, nervous diseases, metabolic diseases, reproductive system diseases, and digestive diseases.[Means for Solving Problems] Compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof: wherein R1 is C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 is phenyl, heteroaryl, or the like; Q is N or CH; and M1, M2, M3 and M4 are each independently hydrogen or C1-6 alkyl, or alternatively M1 together with M2 or M3 forms —CH2-CH2- or the like, or M4 together with M2 or M3 forms —CH2-CH2- or the like, with the proviso that M1, M2, M3, and M4 are such that one —CH2- or —CH2-CH2- group is formed thereamong.

    摘要翻译： [问题]提供用作循环系统疾病，神经疾病，代谢疾病，生殖系统疾病和消化系统疾病的预防药物或补救剂的化合物。 解决问题的方法由通式（I）表示的化合物或其药学上可接受的盐：其中R 1为C 1-6烷基，C 3-8环烷基等; R2是苯基，杂芳基等; Q是N或CH; 并且M1，M2，M3和M4各自独立地为氢或C 1-6烷基，或者M1与M2或M3一起形成-CH 2 -CH 2 - 等，或者M4与M2或M3一起形成-CH 2 -CH 2 - 或 其中，M1，M2，M3和M4是这样形成的，其中形成一个-CH 2 - 或-CH 2 -CH 2 - 基团。

    Sulfonyl-substituted 6-membered ring derivative
    7.
    发明授权
    Sulfonyl-substituted 6-membered ring derivative 有权
    磺酰取代的6元环衍生物

    公开(公告)号：US08124807B2

    公开(公告)日：2012-02-28

    申请号：US12745761

    申请日：2008-12-16

    申请人： Tsuyoshi Nagase ,  Takahide Sasaki ,  Toshiyuki Takahashi

    发明人： Tsuyoshi Nagase ,  Takahide Sasaki ,  Toshiyuki Takahashi

    IPC分类号： C07C233/10 ,  C07D213/62 ,  C07D239/38

    CPC分类号： C07C317/44 ,  C07C2601/14 ,  C07D211/54 ,  C07D213/71 ,  C07D213/75 ,  C07D233/84 ,  C07D239/38 ,  C07D277/36 ,  C07D285/125 ,  C07D401/12 ,  C07D417/12

    摘要： [Problem]To provide a compound that is useful as an agent in the prevention and treatment of circulatory system, nervous system, metabolic, reproductive system, and gastrointestinal diseases.[Means for Resolution]A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I): [wherein, Z represents formula (II-1), (II-2), or (II-3), wherein m and n are 0, 1, or 2, Y represents CR3 or N, R1 represents a C1-6 alkyl, C3-8 cycloalkyl, etc., R2 represents phenyl or a heteroaryl, etc., R3 and R4 each independently represent a hydrogen atom, a C1-6 alkyl, etc., M1, M2, M3, and M4 each independently represent a hydrogen atom, a C1-6 alkyl, etc.]

    摘要翻译： [问题]提供可用作预防和治疗循环系统，神经系统，代谢，生殖系统和胃肠道疾病的药剂的化合物。 [解决方法]由下式（I）表示的化合物或其药学上可接受的盐：[其中，Z表示式（II-1），（II-2）或（II-3），其中m和 n为0,1或2，Y表示CR 3或N，R 1表示C 1-6烷基，C 3-8环烷基等，R 2表示苯基或杂芳基等，R 3和R 4各自独立地表示氢原子 ，C 1-6烷基等，M 1，M 2，M 3和M 4各自独立地表示氢原子，C 1-6烷基等]

    Flexible printed circuit board
    10.
    发明授权
    Flexible printed circuit board 失效
    柔性印刷电路板

    公开(公告)号：US5047895A

    公开(公告)日：1991-09-10

    申请号：US293411

    申请日：1989-01-04

    申请人： Takahide Sasaki

    发明人： Takahide Sasaki

    IPC分类号： H05K1/02 ,  H05K1/11 ,  H05K3/36 ,  H05K3/46

    CPC分类号： H05K3/4685 ,  H05K1/118 ,  H01R12/59 ,  H05K2201/052 ,  H05K2201/09081 ,  H05K2201/10363 ,  H05K3/361

    摘要： A flexible printed circuit board, which has a plurality of signal lines and allows end portions of the signal lines to be electrically connected to another member, is arranged such that an end portion of at least one signal line is made to detour around an end portion of another signal line so as to be introduced into a portion for electrical connection.

    摘要翻译： 具有多个信号线并且允许信号线的端部电连接到另一个部件的柔性印刷电路板被布置成使得至少一条信号线的端部围绕端部部分迂回 的另一个信号线，以便被引入用于电连接的部分。