摘要:
The present invention has searched for a variety of compounds which show IL-12/IL-23 production-inhibitory activities and herein provides a pharmaceutical composition and an agent for preventing or treating IL-12/IL-23 excess production-related diseases, which comprise the compound.
摘要:
By searching various compounds having an inhibiting activity against IL-12/IL-23 production, the present invention provides a pharmaceutical composition or a therapeutic or preventive agent for diseases related to IL-12/IL-23 excessive production each of which comprises the compound(s) of the present invention.More specifically, the present invention provides an imidazopyridazine compound having an inhibiting activity against IL-12/IL-23 production or pharmaceutically acceptable salts thereof; and a useful pharmaceutical composition or a useful therapeutic or preventive agent for diseases related to IL-12/IL-23 excessive production each of which comprises said compound or pharmaceutically acceptable salts thereof.
摘要:
Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要:
Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要:
A spindle motor includes a stationary portion and a rotating portion. The stationary portion preferably includes a shaft portion, an upper thrust portion, and an outer tubular portion. The rotating portion preferably includes an inner tubular portion, a flange portion, an upper hub annular portion, and a lower hub annular portion. The flange portion includes a communicating hole. An upper surface of a lubricating oil is located in a fifth gap defined between an upper thrust portion and an upper hub annular portion, while a lower surface of the lubricating oil is located in a sixth gap defined between an outer tubular portion and a lower hub annular portion. The communicating hole and a space extending from the fifth gap to the sixth gap through a fourth gap, a first gap, a second gap, and a third gap are continuously filled with the lubricating oil.
摘要:
A dynamic pressure bearing is defined in a first gap between a shaft portion and a sleeve portion. An upper seal portion extending upward and a lower seal portion extending downward are arranged radially outward of the dynamic pressure bearing. Each of the upper seal portion and the lower seal portion includes a surface including a lubricating oil located therein. The upper seal portion and the lower seal portion are arranged in communication with each other through a communicating hole defined in the sleeve portion. The communicating hole and a space ranging from the upper seal portion to the lower seal portion through the first gap are filled with the lubricating oil. The axial distance between the surfaces of the lubricating oil in the upper seal portion and the lower seal portion is arranged to be shorter than the axial distance between an upper end and a lower end of the dynamic pressure bearing.
摘要:
A soft contact lens (SCL) package product which can be advantageously supplied to hydrated SCL wearers, a method of shipping a SCL shipped in the form of such a SCL package product and a method of packaging the SCL, are provided. A liquid medium 12 containing at least one anionic compound having two or more anionic functional groups in one molecule and at least one cationic compound having two or more cationic functional groups in one molecule is housed in a sealable container 4 together with a hydrated SCL 10. Then, the container 4 is sealed, and the inside of the container 4 is held in a sterile state to obtain a SCL package product 2.
摘要:
In the present invention, a plurality of ultra-small condenser microphones is formed on a same substrate. Then, charges are fixed to a dielectric film provided in each of the ultra-small condenser microphones. After an amount of deposited charges in each of the dielectric films is inspected, the substrate whereon the plurality of ultra-small condenser microphones is formed is diced so that each of the ultra-small condenser microphones is separated. Thus, at least the step of fixing charges is performed in a substrate state where the plurality of ultra-small condenser microphones is formed on the same substrate. Therefore, the present invention contributes to enhancement of productivity in an assembly process of the ultra-small condenser microphone and reduction in equipment costs.
摘要:
A medium processing apparatus includes a liquid applier and a post-processing device. The liquid applier includes a liquid application member including a foam containable a liquid to apply the liquid to a liquid application region in a part of at least one medium of a bundle of media. The post-processing device performs a given process on a post-processing region in the part of at least one medium having the liquid application region on which the liquid is applied by the liquid applier. The liquid applier applies the liquid to the liquid application region overlapped with at least a part of the post-processing region.
摘要:
An arbitration unit, when a blocking error disabling data from being output to a destination node from an output buffer occurs in any one of the destination nodes, determines an input buffer connected to the output buffer from within the input buffers including the input buffer retaining the data addressed to the destination node in which the blocking error occurs, and a connection switchover unit connects the determined input buffer to the output buffer of the destination node for the data retained in the input buffer.