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    Medical adhesive sheet
    1.
    发明授权
    Medical adhesive sheet 失效
    医用胶片

    公开(公告)号：US6139867A

    公开(公告)日：2000-10-31

    申请号：US296427

    申请日：1994-08-26

    申请人： Takateru Muraoka ,  Takashi Kinoshita ,  Hitoshi Akemi ,  Saburo Otsuka

    发明人： Takateru Muraoka ,  Takashi Kinoshita ,  Hitoshi Akemi ,  Saburo Otsuka

    IPC分类号： A61F13/00 ,  A61F13/02 ,  A61K9/70 ,  A61L15/58 ,  A61L15/44

    CPC分类号： A61K9/7053 ,  A61F13/0233 ,  A61F13/0243 ,  A61F13/0253 ,  A61K9/7061 ,  A61L15/58 ,  A61F2013/00153 ,  A61F2013/00234 ,  A61F2013/00608 ,  A61F2013/00663 ,  A61F2013/0071 ,  A61F2013/00906

    摘要： A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous-sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.

    摘要翻译： 一种医用胶粘片，其特征在于，具有包含无孔片材和多孔片材的叠层结构的支持体和包含通过聚合（甲基）丙烯酸烷基酯作为主要成分单体而制备的丙烯酸类聚合物的压敏层， 在支撑体的多孔片侧形成与丙烯酸类聚合物相容的有机液体成分，该层进行交联处理，其中粘合剂层嵌入多孔片中，到达层间界面 无孔片材和多孔片材。 医用粘合片具有改善其压敏粘合剂层对支持体的锚定性能，同时在与皮肤的粘附性和对皮肤的低刺激性之间具有良好的平衡。

    Package structure of drug-containing pressure-sensitive adhesive sheet
    2.
    发明授权
    Package structure of drug-containing pressure-sensitive adhesive sheet 失效
    含药物压敏胶片的包装结构

    公开(公告)号：US5505306A

    公开(公告)日：1996-04-09

    申请号：US274162

    申请日：1994-07-14

    申请人： Hitoshi Akemi ,  Takashi Kinoshita ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka

    发明人： Hitoshi Akemi ,  Takashi Kinoshita ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka

    IPC分类号： A61B19/02 ,  A61F13/00 ,  A61F15/00 ,  A61K9/70 ,  A61B17/06

    CPC分类号： A61F15/001 ,  A61K9/703 ,  A61K9/7038 ,  A61B2050/002 ,  A61B2050/314 ,  A61F2013/00646 ,  A61F2013/00897

    摘要： A package structure, in which a drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a separator in this order is packaged and sealed in a packaging material, is disclosed, wherein unevenness is provided on at least one of the surface of the support on the side in contact with the inside of the packaging material, the surface of the separator on the side in contact with the inside of the packaging material, and the inside surface of the packaging material. The unevenness reduces the contact area between the packaging material and the sheet so that an adhesive, a plasticizer or any liquid component of the adhesive layer is prevented from adhering to the inside of the packaging material. Therefore, the sheet can easily be taken out of unit package on use.

    摘要翻译： 公开了一种封装结构，其中将包含载体，含药物的粘合剂层和隔膜的药物含压敏粘合片按包装材料包装和密封，其中不均匀性为 设置在与包装材料的内侧接触的一侧的支撑体的表面中的至少一个上，隔板的与包装材料的内部接触的一侧的表面和包装材料的内表面 。 不均匀性降低了包装材料和片材之间的接触面积，从而防止粘合剂，增塑剂或粘合剂层的任何液体成分粘附到包装材料的内部。 因此，在使用时，可以容易地将纸张从单元包装中取出。

    Percutaneous absorption preparation
    3.
    发明授权
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：US5683710A

    公开(公告)日：1997-11-04

    申请号：US527535

    申请日：1995-09-13

    申请人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka ,  Takashi Kinoshita

    发明人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka ,  Takashi Kinoshita

    IPC分类号： A61K9/70 ,  A61K31/34 ,  A61K47/14 ,  A61P9/08 ,  A61P9/10 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K31/34

    摘要： A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.

    摘要翻译： 公开了一种用于通过经皮吸收将硝酸异山梨酯（ISDN）作为冠状血管扩张剂施用于生物体的经皮吸收制剂，其对皮肤具有优异的粘附性，并且在剥离时不引起疼痛和对角质层的损伤 。 压敏粘合剂层包含通过将包含（甲基）丙烯酸烷基酯和官能单体作为主要组分的单体混合物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸酯酯， 特定数量的碳原子和ISDN，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此改善了ISDN的释放，并且可以减少制剂的面积。

    Method for preparing a medical adhesive sheet
    4.
    发明授权
    Method for preparing a medical adhesive sheet 失效
    医用胶片的制备方法

    公开(公告)号：US5876745A

    公开(公告)日：1999-03-02

    申请号：US742487

    申请日：1997-01-23

    申请人： Takateru Muraoka ,  Takashi Kinoshita ,  Hitoshi Akemi ,  Saburo Otsuka

    发明人： Takateru Muraoka ,  Takashi Kinoshita ,  Hitoshi Akemi ,  Saburo Otsuka

    IPC分类号： A61F13/00 ,  A61F13/02 ,  A61K9/70 ,  A61L15/58

    CPC分类号： A61K9/7053 ,  A61F13/0233 ,  A61F13/0243 ,  A61F13/0253 ,  A61K9/7061 ,  A61L15/58 ,  A61F2013/00153 ,  A61F2013/00234 ,  A61F2013/00608 ,  A61F2013/00663 ,  A61F2013/0071 ,  A61F2013/00906

    摘要： A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.

    摘要翻译： 一种医用胶粘片，其特征在于，具有包含无孔片材和多孔片材的叠层结构的支持体和包含通过聚合（甲基）丙烯酸烷基酯作为主要成分单体而制备的丙烯酸类聚合物的压敏层， 形成在载体的多孔片侧的与丙烯酸类聚合物相容的液体成分，该层进行交联处理，其中粘合剂层嵌入多孔片中，到达非粘合层之间的层压体界面， - 多孔片材。 医用粘合片具有改善其压敏粘合剂层对支持体的锚定性能，同时在与皮肤的粘附性和对皮肤的低刺激性之间具有良好的平衡。

    Percutaneous absorption preparation
    5.
    发明授权
    Percutaneous absorption preparation 有权
    经皮吸收制剂

    公开(公告)号：US6132761A

    公开(公告)日：2000-10-17

    申请号：US146666

    申请日：1998-09-03

    申请人： Takateru Muraoka ,  Hitoshi Akemi ,  Keigo Inosaka ,  Hiroko Ishitani ,  Saburo Otsuka

    发明人： Takateru Muraoka ,  Hitoshi Akemi ,  Keigo Inosaka ,  Hiroko Ishitani ,  Saburo Otsuka

    IPC分类号： A61K9/70 ,  A61K47/14 ,  A61K47/22 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K47/14 ,  A61K47/22 ,  A61K9/0014 ,  A61K9/7061

    摘要： The present invention provides a percutaneous absorption preparation which hardly causes the coloration phenomenon and is excellent in the stability of the drug content. The percutaneous absorption preparation comprises a support and a pressure-sensitive adhesive layer formed on at least one side of the support, wherein the pressure-sensitive adhesive layer contains a percutaneous absorptive drug and at least one of 2-mercaptobenzimidazole and propyl gallate, with the proviso that the percutaneous absorptive drug is not 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole and pharmacologically acceptable salt thereof.

    摘要翻译： 本发明提供一种几乎不引起着色现象并且药物含量稳定性优异的经皮吸收制剂。 经皮吸收制剂包括载体和形成在载体的至少一侧上的压敏粘合剂层，其中压敏粘合剂层含有经皮吸收药物和2-巯基苯并咪唑和没食子酸丙酯中的至少一种，其中 条件是经皮吸收药物不是6-氨基-5-氯-1-异丙基-2-（4-甲基-1-哌嗪基）苯并咪唑及其药理学上可接受的盐。

    High molecular-weight medical adhesive with plasticizers, and product thereof
    7.
    发明授权
    High molecular-weight medical adhesive with plasticizers, and product thereof 失效
    具有增塑剂的高分子量医用胶及其制品

    公开(公告)号：US06231883B1

    公开(公告)日：2001-05-15

    申请号：US09117000

    申请日：1998-07-17

    申请人： Keigo Inosaka ,  Takateru Muraoka ,  Hitoshi Akemi ,  Saburo Otsuka ,  Yuichi Inoue

    发明人： Keigo Inosaka ,  Takateru Muraoka ,  Hitoshi Akemi ,  Saburo Otsuka ,  Yuichi Inoue

    IPC分类号： A61L1524

    CPC分类号： A61L15/58

    摘要： A medical adhesive sheet comprising a support and an adhesive layer formed on one side of said support, wherein the adhesive layer comprises an adhesive polymer having a weight average molecular weight of not less than 2,000,000, preferably not less than 2,500,000, and at least one plasticizer compatible with said polymer. The medical adhesive sheet of the present invention simultaneously satisfies the adhesive property to the skin and low irritation property, since it can retain the plasticizer in the adhesive layer, even without a crosslinking treatment. The effects of the present invention can be exerted irrespective of the kind of functional group that the plasticizer and drug have.

    摘要翻译： 一种医用粘合片，其包含支撑体和形成在所述支撑体的一侧上的粘合剂层，其中所述粘合剂层包含重均分子量不小于2,000,000，优选不小于2,500,000的粘合剂聚合物，以及至少一种增塑剂 与所述聚合物相容。 本发明的医用粘合片同时满足与皮肤的粘合性和低刺激性，因为即使不进行交联处理也能够将增塑剂保留在粘合剂层中。 无论增塑剂和药物具有的官能团的种类如何，都可以发挥本发明的效果。

    Percutaneous absorption preparation
    8.
    发明授权
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：US5650165A

    公开(公告)日：1997-07-22

    申请号：US551786

    申请日：1995-11-07

    申请人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Yutaka Suzuki ,  Saburo Otsuka

    发明人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Yutaka Suzuki ,  Saburo Otsuka

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/14 ,  A61K47/32 ,  A01N29/02 ,  A61F13/02 ,  A61K31/035 ,  A61L15/16

    CPC分类号： A61K9/7061 ,  A61K47/14 ,  A61K9/0014

    摘要： This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.

    摘要翻译： 本发明提供一种经皮吸收制剂，用于经皮给药的药物，用于预防或治疗各种疾病，其对皮肤的粘附性优异，并且在剥离时不会引起疼痛和对角质的损伤 关闭 其压敏粘合剂层含有包含（甲基）丙烯酸烷基酯和官能单体作为必要组分的丙烯酸共聚物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸甘油酯和 用于经皮吸收的药物，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此药物从制剂中的释放得到改善，制剂的面积可以小型化。