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公开(公告)号：US5242951A
公开(公告)日：1993-09-07
申请号：US635070
申请日：1990-12-28
申请人： Hitoshi Akemi , Takashi Kinoshita , Saburo Otsuka , Yoshifumi Hosaka , Kunio Tsukamoto , Yoshihisa Nakano
发明人： Hitoshi Akemi , Takashi Kinoshita , Saburo Otsuka , Yoshifumi Hosaka , Kunio Tsukamoto , Yoshihisa Nakano
IPC分类号： A61K9/70 , A61K31/34 , A61K31/565 , A61K31/566 , A61K31/567 , A61K47/02 , A61K47/32 , A61P5/30
CPC分类号： A61K9/7053 , A61K31/34 , A61K31/565 , A61K9/7061 , A61K9/7076
摘要： An estrogen-containing gel preparation is disclosed, which comprises a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) estrogen;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).
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公开(公告)号：US5204109A
公开(公告)日：1993-04-20
申请号：US855493
申请日：1992-03-23
IPC分类号： A61K9/70 , A61K31/34 , A61K31/565
CPC分类号： A61K9/7061 , A61K31/34 , A61K31/565
摘要： A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) isosorbide dinitrate;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).
摘要翻译： 公开了一种经皮凝胶制剂，其包含其一个表面具有通过交联包含以下成分（a）至（c）的组合物，成分（b）与成分（c）的重量比）形成的交联凝胶层的基材 ）为1.0 / 0.25〜1.0 / 2.0：（a）硝酸异山梨酯; （b）丙烯酸酯聚合物; 和（c）与成分（b）相容的液体成分。
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3.发明授权
公开(公告)号：US5298258A
公开(公告)日：1994-03-29
申请号：US899278
申请日：1992-06-16
IPC分类号： A61K9/70 , A61K31/34 , A61K31/565 , A61L15/58 , A61K9/14
CPC分类号： A61K9/7061 , A61K31/34 , A61K31/565 , A61L15/58
摘要： An acrylic oily gel bioadhesive material comprising a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising an acrylate polymer comprising as a main component an alkyl (meth)acrylate having four or more carbon atoms in the alkyl moiety and a liquid ingredient compatible with said acrylate polymer.
摘要翻译： 一种丙烯酸油性凝胶生物粘合剂材料，其包含基材，其一个表面上具有交联凝胶层，所述交联凝胶层通过将包含作为主要组分的丙烯酸酯聚合物的组合物交联而形成，所述组合物包含在烷基部分中具有四个或更多个碳原子的（甲基） 与所述丙烯酸酯聚合物相容的液体成分。
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公开(公告)号：US4954343A
公开(公告)日：1990-09-04
申请号：US406200
申请日：1989-09-12
申请人： Yoshifumi Hosaka , Saburo Otsuka , Takashi Kinoshita , Yusuke Ito
发明人： Yoshifumi Hosaka , Saburo Otsuka , Takashi Kinoshita , Yusuke Ito
CPC分类号： A61K9/7061 , A61L15/58
摘要： A dermal pharmaceutical preparation comprising a soft support having provided thereon a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and a drug, wherein said pressure-sensitive adhesive is a copolymer comprising a (meth)acrylamide having an amino group as a comonomer unit. The preparation remains the drug in a dissolved state and is excellent in drug liberation and adhesion to the skin.
摘要翻译： 一种皮肤药物制剂，其包含在其上设置有含有压敏粘合剂和药物的压敏粘合剂层的软质载体，其中所述压敏粘合剂是包含具有氨基作为共聚单体单元的（甲基）丙烯酰胺的共聚物 。 制剂保持药物溶解状态，药物释放和对皮肤的粘附性优异。
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公开(公告)号：US5683710A
公开(公告)日：1997-11-04
申请号：US527535
申请日：1995-09-13
CPC分类号： A61K9/7061 , A61K31/34
摘要： A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.
摘要翻译： 公开了一种用于通过经皮吸收将硝酸异山梨酯（ISDN）作为冠状血管扩张剂施用于生物体的经皮吸收制剂，其对皮肤具有优异的粘附性，并且在剥离时不引起疼痛和对角质层的损伤 。 压敏粘合剂层包含通过将包含（甲基）丙烯酸烷基酯和官能单体作为主要组分的单体混合物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸酯酯， 特定数量的碳原子和ISDN，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此改善了ISDN的释放，并且可以减少制剂的面积。
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公开(公告)号：US5876745A
公开(公告)日：1999-03-02
申请号：US742487
申请日：1997-01-23
CPC分类号： A61K9/7053 , A61F13/0233 , A61F13/0243 , A61F13/0253 , A61K9/7061 , A61L15/58 , A61F2013/00153 , A61F2013/00234 , A61F2013/00608 , A61F2013/00663 , A61F2013/0071 , A61F2013/00906
摘要： A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.
摘要翻译： 一种医用胶粘片，其特征在于，具有包含无孔片材和多孔片材的叠层结构的支持体和包含通过聚合（甲基）丙烯酸烷基酯作为主要成分单体而制备的丙烯酸类聚合物的压敏层， 形成在载体的多孔片侧的与丙烯酸类聚合物相容的液体成分，该层进行交联处理，其中粘合剂层嵌入多孔片中，到达非粘合层之间的层压体界面， - 多孔片材。 医用粘合片具有改善其压敏粘合剂层对支持体的锚定性能，同时在与皮肤的粘附性和对皮肤的低刺激性之间具有良好的平衡。
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公开(公告)号：US5374429A
公开(公告)日：1994-12-20
申请号：US46962
申请日：1993-04-16
CPC分类号： A61K9/7061 , A61F13/023 , A61L15/58 , B32B27/12 , A61F2013/00578 , A61F2013/00604 , A61F2013/00744 , A61F2013/00906 , A61F2013/0091
摘要： A medical adhesive sheet comprising a support comprising a laminate of a polyester film having a thickness of from 0.5 to 6 .mu.m and a polyester nonwoven fabric having a basis weight of from 5 to 20 g/m.sup.2, and a pressure-sensitive adhesive layer laminated on the surface of the nonwoven fabric.
摘要翻译： 一种医用胶粘片，其特征在于，具有由厚度为0.5〜6μm的聚酯薄膜和单位面积重量为5〜20g / m 2的聚酯无纺布构成的层压体的层叠体和叠层的粘合剂层 在无纺织物的表面上。
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公开(公告)号：US5505306A
公开(公告)日：1996-04-09
申请号：US274162
申请日：1994-07-14
CPC分类号： A61F15/001 , A61K9/703 , A61K9/7038 , A61B2050/002 , A61B2050/314 , A61F2013/00646 , A61F2013/00897
摘要： A package structure, in which a drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a separator in this order is packaged and sealed in a packaging material, is disclosed, wherein unevenness is provided on at least one of the surface of the support on the side in contact with the inside of the packaging material, the surface of the separator on the side in contact with the inside of the packaging material, and the inside surface of the packaging material. The unevenness reduces the contact area between the packaging material and the sheet so that an adhesive, a plasticizer or any liquid component of the adhesive layer is prevented from adhering to the inside of the packaging material. Therefore, the sheet can easily be taken out of unit package on use.
摘要翻译： 公开了一种封装结构，其中将包含载体，含药物的粘合剂层和隔膜的药物含压敏粘合片按包装材料包装和密封，其中不均匀性为 设置在与包装材料的内侧接触的一侧的支撑体的表面中的至少一个上，隔板的与包装材料的内部接触的一侧的表面和包装材料的内表面 。 不均匀性降低了包装材料和片材之间的接触面积，从而防止粘合剂，增塑剂或粘合剂层的任何液体成分粘附到包装材料的内部。 因此，在使用时，可以容易地将纸张从单元包装中取出。
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公开(公告)号：US6139867A
公开(公告)日：2000-10-31
申请号：US296427
申请日：1994-08-26
CPC分类号： A61K9/7053 , A61F13/0233 , A61F13/0243 , A61F13/0253 , A61K9/7061 , A61L15/58 , A61F2013/00153 , A61F2013/00234 , A61F2013/00608 , A61F2013/00663 , A61F2013/0071 , A61F2013/00906
摘要： A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous-sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.
摘要翻译： 一种医用胶粘片，其特征在于，具有包含无孔片材和多孔片材的叠层结构的支持体和包含通过聚合（甲基）丙烯酸烷基酯作为主要成分单体而制备的丙烯酸类聚合物的压敏层， 在支撑体的多孔片侧形成与丙烯酸类聚合物相容的有机液体成分，该层进行交联处理，其中粘合剂层嵌入多孔片中，到达层间界面 无孔片材和多孔片材。 医用粘合片具有改善其压敏粘合剂层对支持体的锚定性能，同时在与皮肤的粘附性和对皮肤的低刺激性之间具有良好的平衡。
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公开(公告)号：US4765974A
公开(公告)日：1988-08-23
申请号：US48977
申请日：1987-05-13
申请人： Shoichi Tokuda , Yuusuke Ito , Saburo Otsuka , Takashi Kinoshita
发明人： Shoichi Tokuda , Yuusuke Ito , Saburo Otsuka , Takashi Kinoshita
CPC分类号： A61K31/415 , A61K47/32 , A61K9/0014
摘要： A clonidine preparation for percutaneous administration comprising a support having provided thereon an active ingredient-containing layer is disclosed. The active ingredient-containing layer contains an acrylic polymer having a glass transition temperature of from -70.degree. C. to -10.degree. C. and pressure-sensitive adhesion at room temperature as a base, at least one of clonidine and clonidine hydrochloride as an active ingredient, and a decomposition inhibitor. The active ingredient can be stably maintained within the preparation without being decomposed, and, therefore, can be effectively released over a prolonged period of time.
摘要翻译： 公开了一种用于经皮给药的可乐定制剂，其包含其上提供有活性成分的层的载体。 活性成分含有层含有玻璃化转变温度为-70℃〜-10℃的丙烯酸类聚合物，作为碱的室温下的压敏粘合剂，可乐定和可乐定盐酸盐中的至少一种作为 活性成分和分解抑制剂。 活性成分可以稳定地保持在制剂中而不被分解，因此可以在更长的时间内有效释放。
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