公开(公告)号：US20070062814A1

公开(公告)日：2007-03-22

申请号：US11604253

申请日：2006-11-27

申请人： Takayasu Furukawa ,  Nobuhiko Sato ,  Syozo Kasai ,  Seiichi Ugai ,  Motohiro Yamazaki ,  Hiroyuki Tanaka ,  Yuki Nonaka ,  Yoshio Onodera ,  Noriyuki Shimoda

发明人： Takayasu Furukawa ,  Nobuhiko Sato ,  Syozo Kasai ,  Seiichi Ugai ,  Motohiro Yamazaki ,  Hiroyuki Tanaka ,  Yuki Nonaka ,  Yoshio Onodera ,  Noriyuki Shimoda

IPC分类号： C07K1/26 ,  G01N27/00

CPC分类号： G01N27/44782 ,  G01N27/44704

摘要： A capillary array capable of being easily mounted on an electrophoresis apparatus without damaging the capillaries. The capillary array can include a plurality of capillaries that can be fixed via hollow electrodes on a load header in a matrix arrangement. The load header can be disposed on the electrophoresis apparatus. The capillary array can include a capillary frame onto which a capillary head and a detection portion can be detachably mounted. The structure allows the load header, the capillary head, the detection unit and other portions of the capillary array to be handled as a unit, thereby making it easier to mount the capillary array on the electrophoresis apparatus.

公开(公告)号：US07156971B2

公开(公告)日：2007-01-02

申请号：US10421887

申请日：2003-04-24

申请人： Takayasu Furukawa ,  Nobuhiko Sato ,  Syozo Kasai ,  Seiichi Ugai ,  Motohiro Yamazaki ,  Hiroyuki Tanaka ,  Yuki Nonaka ,  Yoshio Onodera ,  Noriyuki Shimoda

发明人： Takayasu Furukawa ,  Nobuhiko Sato ,  Syozo Kasai ,  Seiichi Ugai ,  Motohiro Yamazaki ,  Hiroyuki Tanaka ,  Yuki Nonaka ,  Yoshio Onodera ,  Noriyuki Shimoda

IPC分类号： G01N27/453 ,  G01N30/02

CPC分类号： G01N27/44782 ,  G01N27/44704

摘要： A capillary array capable of being easily mounted on an electrophoresis apparatus without damaging the capillaries. The capillary array can include a plurality of capillaries that can be fixed via hollow electrodes on a load header in a matrix arrangement. The load header can be disposed on the electrophoresis apparatus. The capillary array can include a capillary frame onto which a capillary head and a detection portion can be detachably mounted. The structure allows the load header, the capillary head, the detection unit and other portions of the capillary array to be handled as a unit, thereby making it easier to mount the capillary array on the electrophoresis apparatus.

摘要翻译： 一种能够容易地安装在电泳装置上而不损坏毛细管的毛细管阵列。 毛细管阵列可以包括多个毛细管，其可以通过矩阵布置的负载头上的中空电极固定。 负载头可以设置在电泳装置上。 毛细管阵列可以包括毛细管框架，毛细管头和检测部分可以在其上可拆卸地安装在毛细管框架上。 该结构允许负载头，毛细管头，检测单元和毛细管阵列的其它部分作为一个单元被处理，从而使毛细管阵列更容易安装在电泳装置上。

公开(公告)号：US07658830B2

公开(公告)日：2010-02-09

申请号：US11604253

申请日：2006-11-27

申请人： Takayasu Furukawa ,  Nobuhiko Sato ,  Syozo Kasai ,  Seiichi Ugai ,  Motohiro Yamazaki ,  Hiroyuki Tanaka ,  Yuki Nonaka ,  Yoshio Onodera ,  Noriyuki Shimoda

发明人： Takayasu Furukawa ,  Nobuhiko Sato ,  Syozo Kasai ,  Seiichi Ugai ,  Motohiro Yamazaki ,  Hiroyuki Tanaka ,  Yuki Nonaka ,  Yoshio Onodera ,  Noriyuki Shimoda

IPC分类号： G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44704

摘要： A capillary array capable of being easily mounted on an electrophoresis apparatus without damaging the capillaries. The capillary array can include a plurality of capillaries that can be fixed via hollow electrodes on a load header in a matrix arrangement. The load header can be disposed on the electrophoresis apparatus. The capillary array can include a capillary frame onto which a capillary head and a detection portion can be detachably mounted. The structure allows the load header, the capillary head, the detection unit and other portions of the capillary array to be handled as a unit, thereby making it easier to mount the capillary array on the electrophoresis apparatus.

摘要翻译： 一种能够容易地安装在电泳装置上而不损坏毛细管的毛细管阵列。 毛细管阵列可以包括多个毛细管，其可以通过矩阵布置的负载头上的中空电极固定。 负载头可以设置在电泳装置上。 毛细管阵列可以包括毛细管框架，毛细管头和检测部分可以在其上可拆卸地安装在毛细管框架上。 该结构允许负载头，毛细管头，检测单元和毛细管阵列的其它部分作为一个单元被处理，从而使毛细管阵列更容易安装在电泳装置上。

公开(公告)号：US07883613B2

公开(公告)日：2011-02-08

申请号：US11806889

申请日：2007-06-05

申请人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

发明人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

IPC分类号： G01N27/453

CPC分类号： G01N27/44721

摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.

摘要翻译： 本发明提供了一种毛细管电泳装置，其中毛细管容易地连接到迁移介质填充单元并从迁移介质填充单元中分离而不将杂质混入毛细管中。 当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。 此外，在毛细管中有效地进行温度控制。 在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。 迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。 毛细管电泳装置包括可以同时存储样品和缓冲液的容器。 毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

公开(公告)号：US20070278101A1

公开(公告)日：2007-12-06

申请号：US11806889

申请日：2007-06-05

申请人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

发明人： Takashi Gomi ,  Ryoji Inaba ,  Motohiro Yamazaki ,  Hidenori Namba ,  Jin Matsumura ,  Hiromi Yamashita ,  Seiichi Ugai ,  Kazumichi Imai

IPC分类号： G01N27/00

CPC分类号： G01N27/44721

摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.

摘要翻译： 本发明提供了一种毛细管电泳装置，其中毛细管容易地附着到迁移介质填充单元上并从迁移介质填充单元中分离而不将杂质混入毛细管中。 当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。 此外，在毛细管中有效地进行温度控制。 在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。 迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。 毛细管电泳装置包括可以同时存储样品和缓冲液的容器。 毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

公开(公告)号：US20060219559A1

公开(公告)日：2006-10-05

申请号：US11395158

申请日：2006-04-03

申请人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

发明人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

IPC分类号： G01N27/00

CPC分类号： G01N27/44708

摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.

公开(公告)号：US07473342B2

公开(公告)日：2009-01-06

申请号：US11395158

申请日：2006-04-03

申请人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

发明人： Seiichi Ugai ,  Tomonari Morioka ,  Ryoji Inaba ,  Akihiro Suzuki ,  Yoshinori Ookoshi ,  Yoshiyuki Okishima ,  Tsukasa Ohira ,  Motohiro Yamazaki ,  Takashi Gomi

IPC分类号： G01N27/00

CPC分类号： G01N27/44708

摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.

摘要翻译： 在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下，不将样品的凝胶速度控制在一定程度以降低样品的分析性能。 本发明旨在稳定电泳速度。 其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触，从而控制毛细管的温度。 由于根据本发明能够控制温度和毛细管的构件彼此直接接触，所以可以高精度地快速地控制毛细管的温度，使得电泳速度稳定。

公开(公告)号：US20060076239A1

公开(公告)日：2006-04-13

申请号：US11245491

申请日：2005-10-07

申请人： Ryoji Inaba ,  Motohiro Yamazaki ,  Akihiro Suzuki ,  Miho Ozawa ,  Daizo Tokinaga ,  Tomonari Morioka ,  Seiichi Ugai

发明人： Ryoji Inaba ,  Motohiro Yamazaki ,  Akihiro Suzuki ,  Miho Ozawa ,  Daizo Tokinaga ,  Tomonari Morioka ,  Seiichi Ugai

IPC分类号： G01N27/447

CPC分类号： G01N27/447

摘要： In an electrophoresis apparatus comprising capillaries for containing therein fluorescence-labeled substances, and a sensor for irradiating the capillaries with exciting light and detecting fluorescences, the sensor has a substrate including a datum surface for holding thereon the capillaries, and a groove sinking from the datum surface, and the groove has a plurality of reflecting surfaces for reflecting thereon the fluorescences emitted from the capillaries by a plurality of times.

摘要翻译： 在包括用于在其中含有荧光标记物质的毛细管的电泳装置和用于用激发光照射毛细管并检测荧光的传感器中，传感器具有包括用于保持毛细管的基准表面的基底和从基准面凹下的凹槽 表面，并且凹槽具有多个反射表面，用于在其上反射从毛细管发射的荧光多次。

公开(公告)号：US07787120B2

公开(公告)日：2010-08-31

申请号：US12146920

申请日：2008-06-26

申请人： Motohiro Yamazaki ,  Ryoji Inaba ,  Kosaku Toyosaki ,  Shintaro Kubo ,  Takashi Gomi ,  Katsunobu Hama ,  Kiyotoshi Mori ,  Hideyuki Akiyama

发明人： Motohiro Yamazaki ,  Ryoji Inaba ,  Kosaku Toyosaki ,  Shintaro Kubo ,  Takashi Gomi ,  Katsunobu Hama ,  Kiyotoshi Mori ,  Hideyuki Akiyama

IPC分类号： G01J3/10 ,  G01J3/36 ,  G01N21/33

CPC分类号： G01J3/10 ,  G02B5/283 ,  G02B27/1006 ,  G02B27/1086 ,  G02B27/145 ,  G02B27/148

摘要： Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.

摘要翻译： 通过增加照射样品池的光束的光量而不会使紫外线束或可见光束的检测器饱和而提高检测灵敏度。 该分光光度计包括存储待测样品，可见光源和紫外光源的样品池，每个用于提供进入样品的入射光束，分散已经通过样品的光束的分光器， 检测从这种光束（光谱）分散的光束的光检测器，以及从紫外光源反射或透射紫外光束并从可见光源透射或反射可见光束的二向色元件。 光学构造使得已经通过或已被二色性元件反射的紫外光束和可见光束进入样品池。

公开(公告)号：US07459068B2

公开(公告)日：2008-12-02

申请号：US10309729

申请日：2002-12-04

申请人： Eric S. Nordman ,  Miho Ozawa ,  Masaya Kojima ,  Ryoji Inaba ,  Yoshitaka Kodama ,  Motohiro Yamazaki

发明人： Eric S. Nordman ,  Miho Ozawa ,  Masaya Kojima ,  Ryoji Inaba ,  Yoshitaka Kodama ,  Motohiro Yamazaki

IPC分类号： G01N27/26 ,  G01N27/447

CPC分类号： G01N27/44704 ,  G01N27/44708 ,  G01N27/44782

摘要： A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The multi-capillary electrophoresis apparatus can contain a multi-capillary array that has a separation medium filled therein for isolating a sample. A detector component can be provided at a position remote from a sample injecting end of the array for acquiring information from the sample. A buffer container can be provided for holding a buffer solution into which the sample injecting end can be immersed. One or more temperature controlling component devices can be arranged for controlling a temperature of the buffer solution, of the detector component, or of both the buffer solution and the detector component.

摘要翻译： 提供了一种多毛细管电泳装置，用于减少由于装置的多个毛细管之间的电泳时间波动引起的分析过程中的误差。 多毛细管电泳装置可以包含多个毛细管阵列，其具有填充在其中的分离介质，用于分离样品。 可以在远离阵列的样品注入端的位置处提供检测器部件，以从样品获取信息。 可以提供缓冲容器用于保持可以浸入样品注入端的缓冲溶液。 可以布置一个或多个温度控制部件装置，用于控制缓冲溶液，检测器部件或缓冲溶液和检测器部件两者的温度。