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公开(公告)号:US20100010241A1
公开(公告)日:2010-01-14
申请号:US12519442
申请日:2007-12-26
IPC分类号: C07D405/14
CPC分类号: C07D311/72 , A61K8/86 , A61K2800/522 , A61Q1/02 , A61Q5/06 , A61Q17/04 , A61Q19/00 , A61Q19/02 , Y10S514/844
摘要: The present invention provides a cosmetic having equal to or a higher antioxidant activity and moisture retaining property than the above-described conventional vitamin E derivatives. The cosmetic also has an excellent emulsifying ability and solubilizing ability and remarkably reduces a sticky feeling on the skin (in particular, the sticky feeling during drying after the application on the skin). That is, the cosmetic of the present invention containing a vitamin E derivative represented by the following formula (I) or a salt thereof. [In the formula, R1, R2, and R3 represent a hydrogen atom or a methyl group; R4 represents a C1-6 alkanoyl group, a C1-6 alkyl group, a SO3H group, a P(O)(OH)2 group, a CH2COOH group or a COCH2CH(SO3H)COOH group; EO represents an ethylene oxide group; BO represents a butylene oxide group; k and n independently represent any one of numbers 0 to 30; and m represents any one of numbers 1 to 30.]
摘要翻译: 本发明提供具有与上述常规维生素E衍生物相同或更高抗氧化活性和保湿性的化妆品。 化妆品还具有优异的乳化能力和增溶能力,并且显着降低了皮肤上的粘性感(特别是施用于皮肤后的干燥时的粘着感)。 也就是说,含有下式(I)表示的维生素E衍生物或其盐的本发明的化妆品。 [式中,R 1,R 2,R 3表示氢原子或甲基。 R4表示C1-6烷酰基,C1-6烷基,SO3H基,P(O)(OH)2基,CH2COOH基或COCH2CH(SO3H)COOH基; EO表示环氧乙烷基; BO代表环氧丁烷基团; k和n独立地表示数字0至30中的任一个; m表示数字1〜30中的任一个。]
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公开(公告)号:US08080581B2
公开(公告)日:2011-12-20
申请号:US12519442
申请日:2007-12-26
IPC分类号: A61K31/355 , C07D311/72
CPC分类号: C07D311/72 , A61K8/86 , A61K2800/522 , A61Q1/02 , A61Q5/06 , A61Q17/04 , A61Q19/00 , A61Q19/02 , Y10S514/844
摘要: The present invention provides a cosmetic having equal to or a higher antioxidant activity and moisture retaining property than the above-described conventional vitamin E derivatives. The cosmetic also has an excellent emulsifying ability and solubilizing ability and remarkably reduces a sticky feeling on the skin (in particular, the sticky feeling during drying after the application on the skin). That is, the cosmetic of the present invention containing a vitamin E derivative represented by the following formula (I) or a salt thereof. [In the formula, R1, R2, and R3 represent a hydrogen atom or a methyl group; R4 represents a C1-6 alkanoyl group, a C1-6 alkyl group, a SO3H group, a P(O)(OH)2 group, a CH2COOH group or a COCH2CH(SO3H)COOH group; EO represents an ethylene oxide group; BO represents a butylene oxide group; k and n independently represent any one of numbers 0 to 30; and m represents any one of numbers 1 to 30.]
摘要翻译: 本发明提供具有与上述常规维生素E衍生物相同或更高抗氧化活性和保湿性的化妆品。 化妆品还具有优异的乳化能力和增溶能力,并且显着降低了皮肤上的粘性感(特别是施用于皮肤后的干燥时的粘着感)。 也就是说,含有下式(I)表示的维生素E衍生物或其盐的本发明的化妆品。 [式中,R 1,R 2,R 3表示氢原子或甲基。 R4表示C1-6烷酰基,C1-6烷基,SO3H基,P(O)(OH)2基,CH2COOH基或COCH2CH(SO3H)COOH基; EO表示环氧乙烷基; BO代表环氧丁烷基团; k和n独立地表示数字0至30中的任一个; m表示数字1〜30中的任一个。]
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公开(公告)号:US20050180931A1
公开(公告)日:2005-08-18
申请号:US10513823
申请日:2003-03-07
申请人: Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takayuki Omura
发明人: Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takayuki Omura
摘要: The present invention is a skin treatment composition that characteristically contains an alkyl benzoate represented by the following general formula (1). This provides a skin treatment composition that gives a refreshing sensation at the time of application and can contain drugs and ultraviolet absorbents in a stable manner. Also, the present invention is a sunblock water-in-oil type emulsified cosmetic characteristically comprising an ester bond product of polyhydroxystearic acid represented by the following general formulas (2) or (3), alkyl benzoate represented by the following general formula (1), and an ultraviolet absorbent. This provides a sunblock cosmetic consisting of a water-in-oil type emulsified composition that can contain an ultraviolet absorbent in a stable manner and exhibits a superior usability. (In this formula, R denotes a branched or straight chain alkyl group having 8-15 carbon atoms.) (In this formula, R1 and R2 denote, independently of each other, a hydrogen atom or a lower alkyl group having 1-6 carbon atoms, a+b denotes an integer 1-30, and m denotes an integer 10-200.) (In this formula, R1 and R2 denote, independently of each other, a hydrogen atom or a lower alkyl group having 1-6 carbon atoms, a+b denotes an integer 1-30, and n denotes an integer 1-30.)
摘要翻译: 本发明是特征性地含有下述通式(1)表示的苯甲酸烷基酯的皮肤处理组合物。 这提供了在使用时给予清爽感的皮肤处理组合物,并且可以稳定地含有药物和紫外线吸收剂。 另外,本发明是一种防晒油包水型乳化化妆品,其特征在于,含有下述通式(2)或(3)表示的多羟基硬脂酸的酯键,下述通式(1)表示的苯甲酸烷基酯, ,和紫外线吸收剂。 这提供了由油包水型乳化组合物组成的防晒化妆品,其可以稳定地包含紫外线吸收剂并显示出优异的可用性。 (在该式中,R表示碳原子数为8〜15的支链或直链烷基)(式中,R 1,R 2,R 2, 彼此为氢原子或具有1-6个碳原子的低级烷基,a + b表示1-30的整数,m表示10-200的整数。)(在该式中,R 1' SUP>和R 2彼此独立地表示氢原子或具有1-6个碳原子的低级烷基,a + b表示1-30的整数,n表示整数1 -30。)
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公开(公告)号:US07445790B2
公开(公告)日:2008-11-04
申请号:US10513823
申请日:2003-05-07
申请人: Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takayuki Omura
发明人: Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takayuki Omura
IPC分类号: A61K8/02 , A61K31/235
摘要: The present invention is a skin treatment composition that characteristically contains an alkyl benzoate represented by the following general formula (1).This provides a skin treatment composition that gives a refreshing sensation at the time of application and can contain drugs and ultraviolet absorbents in a stable manner.Also, the present invention is a sunblock water-in-oil type emulsified cosmetic characteristically comprising an ester bond product of polyhydroxystearic acid represented by the following general formulas (2) or (3), alkyl benzoate represented by the following general formula (1), and an ultraviolet absorbent.This provides a sunblock cosmetic consisting of a water-in-oil type emulsified composition that can contain an ultraviolet absorbent in a stable manner and exhibits a superior usability. (In this formula, R denotes a branched or straight chain alkyl group having 8-15 carbon atoms.) (In this formula, R1 and R2 denote, independently of each other, a hydrogen atom or a lower alkyl group having 1-6 carbon atoms, a+b denotes an integer 1-30, and m denotes an integer 10-200.) (In this formula, R1 and R2 denote, independently of each other, a hydrogen atom or a lower alkyl group having 1-6 carbon atoms, a+b denotes an integer 1-30, and n denotes an integer 1-30.)
摘要翻译: 本发明是特征性地含有下述通式(1)表示的苯甲酸烷基酯的皮肤处理组合物。 这提供了在使用时给予清爽感的皮肤处理组合物,并且可以稳定地含有药物和紫外线吸收剂。 另外,本发明是一种防晒油包水型乳化化妆品,其特征在于,含有下述通式(2)或(3)表示的聚羟基硬脂酸的酯键,由以下通式(1)表示的苯甲酸烷基酯, ,和紫外线吸收剂。 这提供了由油包水型乳化组合物组成的防晒化妆品,其可以稳定地包含紫外线吸收剂并显示出优异的可用性。 (在该式中,R表示碳原子数为8〜15的支链或直链烷基)(式中,R 1,R 2,R 2, 彼此为氢原子或具有1-6个碳原子的低级烷基,a + b表示1-30的整数,m表示10-200的整数。)(在该式中,R 1' SUP>和R 2彼此独立地表示氢原子或具有1-6个碳原子的低级烷基,a + b表示1-30的整数,n表示整数1 -30。)
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公开(公告)号:US07625574B2
公开(公告)日:2009-12-01
申请号:US10134441
申请日:2002-04-30
申请人: Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
发明人: Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
CPC分类号: A61K8/39 , A61K8/34 , A61K8/347 , A61K8/676 , A61K8/90 , A61K9/0014 , A61K47/08 , A61K47/10 , A61Q5/00 , A61Q15/00 , A61Q19/00 , Y10S514/946 , Y10S514/947
摘要: A skin treatment composition of the present invention is an external composition for skin comprising an alkylene oxide derivative expressed by Formula (I): R1O—[(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group of C3 or C4; EO is an oxyethylene group; m and n are 1≦m≦70 and 1≦n≦70 respectively, wherein EO is 20˜80% by weight with respect to a total of AO and EO; each of R1 and R2 is a hydrogen or a hydrocarbon group having C1-4. The alkylene oxide derivative (I) has a moisturizing effect, a rough skin improving effect, a stickiness improving effect, and a transdermal absorption promoting effect. When a refreshing agent is used together therewith in the composition of the present invention, the refreshing effect lasts for a long time and it is excellent in feeling of use without skin stimulation.
摘要翻译: 本发明的皮肤治疗组合物是皮肤外用组合物,其含有式(I)表示的烯化氧衍生物:R1O - [(AO)m(EO)n] -R2(Ⅰ)其中,AO为氧化烯基 C3或C4; EO是氧乙烯基; m和n分别为1≤m≤70和1≤n≤70,其中EO相对于AO和EO的总和为20〜80重量% R 1和R 2各自为氢或具有C 1-4的烃基。 氧化烯衍生物(I)具有保湿效果,粗糙的皮肤改善效果,粘着性改善效果和透皮吸收促进效果。 当与本发明的组合物一起使用清新剂时,清爽效果持续很长时间,并且在没有皮肤刺激的情况下使用感觉优异。
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公开(公告)号:US07169379B2
公开(公告)日:2007-01-30
申请号:US10362171
申请日:2002-01-17
申请人: Hirokazu Kouzuki , Morihiro Hirota , Tomoyuki Inaba , Haruhiko Inoue , Hiroshi Itagaki , Hiroyuki Kakoki , Takafumi Kurosawa
发明人: Hirokazu Kouzuki , Morihiro Hirota , Tomoyuki Inaba , Haruhiko Inoue , Hiroshi Itagaki , Hiroyuki Kakoki , Takafumi Kurosawa
CPC分类号: A61K9/0014 , A61K8/345 , A61K8/37 , A61K8/86 , A61K31/07 , A61K47/10 , A61K47/14 , A61K2800/75 , A61Q1/02 , A61Q1/06 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要: The cosmetic of the present invention is a cosmetic that alleviates skin irritation by blending in polypropylene glycol, a specific polar oil, or polybutylene glycol, as well as an ultraviolet absorbent. The present invention also relates to an agent and a method for alleviating irritation by lipophilic drugs. Since the present invention alleviates skin irritation due to ultraviolet absorbents and lipophilic drugs in cosmetics, any amount of ultraviolet absorbents and lipophilic drugs can be blended in cosmetics, and therefore cosmetics that can fully manifest their effects can be provided. Also, it is possible to prepare a safe sunblock cosmetic with superior ultraviolet protection effects because the ultraviolet absorbent is not absorbed through skin.
摘要翻译: 本发明的化妆品是通过在聚丙二醇,特定极性油或聚丁二醇中共混而减轻皮肤刺激的化妆品以及紫外线吸收剂。 本发明还涉及一种减轻亲脂性药物刺激的药剂和方法。 由于本发明减轻化妆品中的紫外线吸收剂和亲脂性药物引起的皮肤刺激,所以可以在化妆品中掺入任意量的紫外线吸收剂和亲油性药物,能够充分发挥其效果的化妆品。 此外,由于紫外线吸收剂不被皮肤吸收,因此可以制备具有优异的紫外线防护效果的安全防晒化妆品。
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公开(公告)号:US5693255A
公开(公告)日:1997-12-02
申请号:US213023
申请日:1994-03-15
IPC分类号: A61K8/06 , A61K8/34 , A61K8/36 , A61K8/92 , A61K9/107 , A61K47/10 , A61K47/12 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , B01J13/00
CPC分类号: A61Q19/00 , A61K8/06 , A61K8/062 , A61K2800/21 , A61Q17/04 , A61Q19/02 , A61Q5/00 , Y10S514/846 , Y10S514/943 , Y10S514/944 , Y10S516/909 , Y10S516/914 , Y10S516/917 , Y10S516/919 , Y10S516/923
摘要: An oil-in-water type emulsion composition comprising: an amphiphile and a surfactant selected from the substances which can form a gel in an amphiphatic substance-surfactant-water system at a temperature of not lower than ordinary temperatures; oil and water, wherein substantially the total amount of amphiphile and surfactant exist on the boundary surfaces of emulsion particles. The emulsion composition has both the physical properties close to those of an aqueous solution and a creamy feel at the time of use.
摘要翻译: 一种水包油型乳剂组合物,其特征在于,包括:两亲物和表面活性剂,其选自可以在不低于常温的温度下在两亲性物质 - 表面活性剂 - 水体系中形成凝胶的物质; 油和水,其中在乳液颗粒的边界表面上基本上存在两亲物和表面活性剂的总量。 乳液组合物具有接近水溶液的物理性质和使用时的乳脂感。
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公开(公告)号:US5162377A
公开(公告)日:1992-11-10
申请号:US366569
申请日:1989-06-15
IPC分类号: A61K8/06 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/55 , A61K8/63 , A61K8/67 , A61K8/86 , A61K8/92 , A61K9/107 , A61Q19/00
CPC分类号: A61K8/06 , A61K8/37 , A61K8/416 , A61K8/42 , A61K8/43 , A61K8/553 , A61K8/63 , A61K8/671 , A61K8/678 , A61K8/86 , A61K8/92 , A61K9/1075 , A61Q19/00 , A61K2800/21 , A61K2800/262 , A61Q5/00 , Y10S514/941 , Y10S514/975
摘要: A transparent composition containing a phospholipid, at least one cationic or nonionic surfactant, an oily component, and water.
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公开(公告)号:US08282910B2
公开(公告)日:2012-10-09
申请号:US12528119
申请日:2008-02-22
申请人: Nozomi Oguchi , Yukie Yoda , Hiroyuki Kakoki
发明人: Nozomi Oguchi , Yukie Yoda , Hiroyuki Kakoki
CPC分类号: A61K8/37 , A61K8/35 , A61K8/40 , A61K2800/59 , A61K2800/592 , A61Q17/04
摘要: The present invention provides a composition for skin or hair which achieves an excellent UV absorption in a wide range of UV wavelength from the UV-A to the UV-B without inhibiting the effect of the alkyl β,β-diphenylacrylate and the α-cyano-β,β-diphenylacrylate (e.g. octocrylene) which serve to improve the photostability of dibenzoylmethane derivative. The composition for skin or hair comprises: (a) a dibenzoylmethane derivative, (b) an alkyl β,β-diphenylacrylate and/or an α-cyano-β,β-diphenylacrylate (e.g. octocrylene), and (c) a specific benzalmalonate derivative (e.g. di(2-ethylhexyl)-4-methoxybenzalmalonate).
摘要翻译: 本发明提供了一种皮肤或头发的组合物,其在从UV-A到UV-B的宽紫外波长范围内具有优异的UV吸收,而不抑制烷基和二苯基丙烯酸酯和α - 氰基 - 和bgr-二苯基丙烯酸酯(例如氰二烯),其用于改善二苯甲酰甲烷衍生物的光稳定性。 用于皮肤或毛发的组合物包括:(a)二苯甲酰甲烷衍生物,(b)丙烯酸烷基酯和/或α-氰基 - 和二苯基丙烯酸酯(例如亚辛基)和(c )特定的亚苄基丙二酸酯衍生物(例如二(2-乙基己基)-4-甲氧基苯甲醛丙二酸酯)。
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公开(公告)号:US20110142774A1
公开(公告)日:2011-06-16
申请号:US12996977
申请日:2009-06-12
申请人: Noriko Tomita , Reiji Miyahara , Hiroyuki Kakoki
发明人: Noriko Tomita , Reiji Miyahara , Hiroyuki Kakoki
摘要: The present invention provides an oil-in-oil type cosmetic composition that has excellent transfer resistance after application, a luster, favorable spreadability during application, and also excellent stability. The oil-in-oil type cosmetic composition comprises (a) 5 to 80% by mass of non-volatile hydrocarbon oil, (b) 1 to 70% by mass of non-volatile silicone oil, and (c) 0.1 to 10% by mass of dextrin fatty acid ester. Preferably, the non-volatile hydrocarbon oil (a) and the non-volatile silicone oil (b) are formulated at a ratio (mass ratio) of (a)/[(a)+(b)]=0.4 to 0.8.
摘要翻译: 本发明提供一种油性油型化妆品组合物,其在涂布后具有优异的耐转移性,光泽,涂布时的良好的铺展性,以及优异的稳定性。 油包油型化妆品组合物包含(a)5〜80质量%的非挥发性烃油,(b)1〜70质量%的非挥发性硅油,(c)0.1〜10质量% 的糊精脂肪酸酯。 优选以(a)/ [(a)+(b)] = 0.4〜0.8的比例(质量比)配制非挥发性烃油(a)和非挥发性硅油(b)。
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