公开(公告)号：US11857575B2

公开(公告)日：2024-01-02

申请号：US15772668

申请日：2016-11-02

申请人： Takeda Pharmaceutical Company Limited

发明人： Olga De La Rosa ,  Eleuterio Lombardo ,  Wilfried Dalemans ,  Javier Garcia Casado ,  Rebeca Blazquez Duran ,  Francisco Miguel Sanchez Margallo

IPC分类号： A61K35/02 ,  A61K9/127 ,  A61K9/50 ,  C12N15/62 ,  A61P29/00 ,  A61P37/06 ,  A61K45/06 ,  A61K35/35 ,  A61K31/519 ,  A61K31/4709 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/5377 ,  G01N1/40 ,  C12N5/0775 ,  A61K35/12 ,  A61K35/28

CPC分类号： A61K35/28 ,  A61K9/127 ,  A61K9/5068 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/519 ,  A61K31/5377 ,  A61K35/35 ,  A61K45/06 ,  A61P29/00 ,  A61P37/06 ,  C12N15/625 ,  A61K2035/122 ,  A61K2035/128 ,  A61K2300/00 ,  C12N5/0667 ,  G01N1/4077 ,  A61K31/4709 ,  A61K2300/00 ,  A61K31/5377 ,  A61K2300/00 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/444 ,  A61K2300/00 ,  A61K31/519 ,  A61K2300/00 ,  A61K35/28 ,  A61K2300/00

摘要： The invention relates to exosomes derived from mesenchymal stem cells and well as isolated populations of said exosomes and method for preparing said isolated exosome populations. The invention also relates to a pharmaceutical composition comprising said exosome or isolated exosome population and their use in a method of treating an immune-mediated inflammatory disease in a subject.