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22 条记录 (耗时 0.038 秒)

    Spiro compounds
    1.
    发明授权
    Spiro compounds 失效
    螺环化合物

    公开(公告)号：US07205417B2

    公开(公告)日：2007-04-17

    申请号：US10485955

    申请日：2002-08-02

    申请人： Takehiro Fukami ,  Katsumasa Nonoshita ,  Takeshi Sagara ,  Hiroyuki Kishino

    发明人： Takehiro Fukami ,  Katsumasa Nonoshita ,  Takeshi Sagara ,  Hiroyuki Kishino

    IPC分类号： C07D307/94 ,  C07D407/12 ,  A61K31/4525

    CPC分类号： C07D401/12 ,  A61K31/4747 ,  C07D209/96 ,  C07D307/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/10 ,  C07D491/10

    摘要： Compounds of the formula (I): (wherein A is an optionally substituted straight-chain hydrocarbon having 1 to 6 carbon atoms, which is optionally intervened by oxygen or nitrogen atom; Ar1 is aryl or heteroaryl, any of which is optionally substituted; n is 0 or 1; R0 is hydrogen, or lower alkylene attached to an arbitrary, bondable position of A; T, U, V and W are independently nitrogen atom or optionally substituted methine, and at least two of T, U, V and W are said methine group; X is —N(SO2R1)—, —N(COR2)— or —CO—; Y is —C(R3)(R4)—, —O— or —N(R5)—; Z is methine or nitrogen atom) exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, etc., sexual and reproductive dysfunctions, and gastro-intestinal motility disorder.

    摘要翻译： 式（I）的化合物：

    Frequency modulator and FM transmission circuit using the same
    2.
    发明授权
    Frequency modulator and FM transmission circuit using the same 失效
    频率调制器和FM传输电路使用相同

    公开(公告)号：US07936228B2

    公开(公告)日：2011-05-03

    申请号：US12096528

    申请日：2006-12-05

    申请人： Hirofumi Komori ,  Takeshi Sagara

    发明人： Hirofumi Komori ,  Takeshi Sagara

    IPC分类号： H04H20/48 ,  H03C3/00

    CPC分类号： H03C3/095 ,  H04H20/48

    摘要： An input signal is input via a first resistor to an inverting input terminal of an operational amplifier. A second resistor is provided on a feedback path between an output terminal and the inverting input terminal of the operational amplifier. A control voltage Vcnt output from the operational amplifier is input to a VCO. A frequency divider frequency-divides an output signal Sout of the VCO. A phase comparator compares an output signal from the frequency divider with a reference clock signal and outputs a voltage according to a phase difference. A loop filter removes a high-frequency component of an output voltage Vcp of the phase comparator and outputs the voltage to a non-inverting input terminal of the operational amplifier.

    摘要翻译： 输入信号通过第一电阻输入到运算放大器的反相输入端。 第二电阻器设置在运算放大器的输出端子和反相输入端子之间的反馈路径上。 从运算放大器输出的控制电压Vcnt被输入到VCO。 分频器对VCO的输出信号Sout进行分频。 相位比较器将来自分频器的输出信号与参考时钟信号进行比较，并根据相位差输出电压。 环路滤波器去除相位比较器的输出电压Vcp的高频分量，并将该电压输出到运算放大器的非反相输入端。

    Frequency modulator using PLL
    3.
    发明授权
    Frequency modulator using PLL 失效
    使用PLL的频率调制器

    公开(公告)号：US07667553B2

    公开(公告)日：2010-02-23

    申请号：US11706677

    申请日：2007-02-15

    申请人： Takeshi Sagara

    发明人： Takeshi Sagara

    IPC分类号： H03C3/06

    CPC分类号： H03L7/093 ,  H03C3/095 ,  H03L7/0891 ,  H03L7/18

    摘要： In a frequency modulator, a VCO oscillates at a frequency according to a voltage applied to an input terminal. A divider divides an output signal of the VCO. A phase comparator compares the output of the divider with a reference clock signal and outputs a voltage corresponding to a phase difference. A loop filter is provided on a path leading from an output terminal of the phase comparator to the input terminal of the VCO, and the loop filter removes a high-frequency component of an output voltage of the phase comparator. A terminal for inputting a modulation signal is provided in the loop filter, separately from a terminal connected with the path leading from the output terminal of the phase comparator to the input terminal of the VCO.

    摘要翻译： 在频率调制器中，VCO根据施加到输入端子的电压以频率振荡。 分频器分频VCO的输出信号。 相位比较器将分频器的输出与参考时钟信号进行比较，并输出与相位差对应的电压。 在从相位比较器的输出端子到VCO的输入端的路径上设置环路滤波器，并且环路滤波器去除相位比较器的输出电压的高频分量。 用于输入调制信号的端子设置在环路滤波器中，与与从相位比较器的输出端子引导到VCO的输入端子的路径连接的端子分开。

    N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
    4.
    发明申请
    N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives 有权
    N-二羟基烷基取代的2-氧代 - 咪唑衍生物

    公开(公告)号：US20070015792A1

    公开(公告)日：2007-01-18

    申请号：US11484203

    申请日：2006-07-11

    申请人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

    发明人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

    IPC分类号： A61K31/454 ,  C07D403/04

    CPC分类号： C07D403/04

    摘要： The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphatic carbocyclic group. These compounds act as nociceptin receptor antagonist, and are useful, for example, as relievers against tolerance to narcotic analgesic, dependence on narcotic analgesic or addiction; analgesic enhancers; antiobestic or appetite suppressors; treating or prophylactic agents for cognitive impairment and dementia/amnesia; agents for treating developmental cognitive abnormality; remedy for schizophrenia; agents for treating neurodegenerative diseases; anti-depressant or treating agents for affective disorder; treating or prophylactic agents for diabetes insipidus; treating or prophylactic agents for polyuria; and remedy for hypotension and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物，其中R代表二羟基取代的C 1 -C 6烷基，Cy代表任选地 取代的C 6 -C 10 - 二环或三环脂族碳环基团。 这些化合物作为伤害感受肽受体拮抗剂起作用，例如可用作对麻醉止痛药的耐受性，对麻醉性镇痛药或成瘾的依赖; 镇痛增强剂; 抗生素或食欲抑制剂; 认知障碍和痴呆/遗忘症的治疗或预防剂; 治疗发育性认知异常的药剂; 精神分裂症补救措施 治疗神经变性疾病的药剂; 用于情感障碍的抗抑郁药或治疗剂; 尿崩症的治疗或预防剂; 多尿症的治疗或预防剂; 并补救低血压等。

    Surgical edged tool
    10.
    发明申请
    Surgical edged tool 审中-公开
    外科边缘工具

    公开(公告)号：US20090062810A1

    公开(公告)日：2009-03-05

    申请号：US12230715

    申请日：2008-09-04

    申请人： Takeshi Sagara

    发明人： Takeshi Sagara

    IPC分类号： A61F9/007

    CPC分类号： A61F9/0133 ,  A61B17/3211

    摘要： A blade plate 2 includes cutting edges 5 on both sides in a lateral direction Y. The cutting edges 5 extend along a longitudinal direction X. Each cutting edge 5 includes an arcuate distal cutting edge 8 and a main cutting edge 10. The distal cutting edges 8 are continuous via a distal joining portion 7. Each main cutting edge 10 extends from the corresponding distal cutting edge 8 via an intermediate joining portion 9 toward the proximal portion of the blade plate 2 to an cutting edge end portion 11. The width W8 between the distal cutting edges 8 of the cutting edges 5 gradually increases from the distal joining portion 7 toward the intermediate joining portions 9. The width W10 between the main cutting edges 10 of the cutting edges 5 gradually increases from the intermediate joining portions 9 toward the cutting edge ends 11. The width W11 between the cutting edge ends 11 of the cutting edges 5 is 2.0 mm or less.

    摘要翻译： 刀片板2在横向方向Y的两侧包括切削刃5.切削刃5沿着纵向方向X延伸。每个切削刃5包括弧形远端切削刃8和主切削刃10.远端切削刃 8通过远端连接部分7连续。每个主切削刃10通过中间连接部分9从相应的远端切削刃8朝向刀片2的近端部分延伸到切削刃端部11。 切削刃5的前端切削刃8从远端接合部7朝向中间接合部9逐渐增大。切削刃5的主切削刃10之间的宽度W10从中间接合部9逐渐向切削 切削刃5的切削刃端11之间的宽度W11为2.0mm以下。