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    PROCESS FOR PRODUCING DIAMINE DERIVATIVE
    1.
    发明申请
    PROCESS FOR PRODUCING DIAMINE DERIVATIVE 有权
    生产二胺衍生物的方法

    公开(公告)号：US20120041206A1

    公开(公告)日：2012-02-16

    申请号：US13228928

    申请日：2011-09-09

    申请人： Takeo Koyama ,  Satoshi Kondo

    发明人： Takeo Koyama ,  Satoshi Kondo

    IPC分类号： C07D213/74 ,  C07D513/04

    CPC分类号： C07D213/75 ,  C07D513/04

    摘要： The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a process for industrially producing a compound (1) represented by the following formula (1): wherein Boc represents a tert-butoxycarbonyl group.

    摘要翻译： 要解决的问题是提供生产FXa抑制剂的重要中间体。 其溶液是工业上制备由下式（1）表示的化合物（1）的方法：其中Boc表示叔丁氧基羰基。

    Process for producing diamine derivative
    2.
    发明授权
    Process for producing diamine derivative 有权
    二胺衍生物的制备方法

    公开(公告)号：US08357808B2

    公开(公告)日：2013-01-22

    申请号：US13228928

    申请日：2011-09-09

    申请人： Takeo Koyama ,  Satoshi Kondo

    发明人： Takeo Koyama ,  Satoshi Kondo

    IPC分类号： C07D213/72

    CPC分类号： C07D213/75 ,  C07D513/04

    摘要： The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a process for industrially producing a compound (1) represented by the following formula (1): wherein Boc represents a tert-butoxycarbonyl group.

    摘要翻译： 要解决的问题是提供生产FXa抑制剂的重要中间体。 其溶液是工业上制备由下式（1）表示的化合物（1）的方法：其中Boc表示叔丁氧基羰基。

    Method for producing diamine derivative
    3.
    发明授权
    Method for producing diamine derivative 有权
    二胺衍生物的制备方法

    公开(公告)号：US08404847B2

    公开(公告)日：2013-03-26

    申请号：US13162922

    申请日：2011-06-17

    申请人： Takeo Koyama

    发明人： Takeo Koyama

    IPC分类号： A61K31/44 ,  C07D513/02

    CPC分类号： C07D513/04 ,  A61K31/444

    摘要： The present invention provides a method for producing a compound represented by formula (A), the method comprising the steps of: (a) mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate at less than 1 molar equivalent with respect to the compound represented by formula (B) in a solvent under heating; (b) adding additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the mixed solution under cooling, wherein the additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate is added in such an amount that the total molar equivalent thereof with the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate of step (a) is 1 molar equivalent or more with respect to the compound represented by formula (B) of step (a); and (c) subsequently allowing the mixed solution to crystallize to obtain the compound represented by formula (A).

    摘要翻译： 本发明提供一种制备由式（A）表示的化合物的方法，该方法包括以下步骤：（a）将式（B）表示的化合物与对甲苯磺酸或对甲苯磺酸一水合物混合， 相对于由式（B）表示的化合物在加热溶剂中为1摩尔当量; （b）在冷却下向混合溶液中加入另外的对甲苯磺酸或对甲苯磺酸一水合物，其中加入额外的对甲苯磺酸或对甲苯磺酸一水合物，其量使得其与p的总摩尔当量 步骤（a）的对甲苯磺酸或对甲苯磺酸一水合物相对于步骤（a）的式（B）表示的化合物为1摩尔当量以上。 和（c）随后使混合溶液结晶，得到由式（A）表示的化合物。

    Power supply with switched starting circuit
    4.
    发明授权
    Power supply with switched starting circuit 失效
    电源带开关电路

    公开(公告)号：US5581453A

    公开(公告)日：1996-12-03

    申请号：US292428

    申请日：1994-08-18

    申请人： Mitsunori Ueta ,  Takeo Koyama

    发明人： Mitsunori Ueta ,  Takeo Koyama

    IPC分类号： H02J1/00 ,  G05F1/10 ,  G05F1/66 ,  H02M3/28 ,  H02M7/517

    CPC分类号： H02M1/36 ,  G05F1/66 ,  H02M2001/0006

    摘要： A switching type power supply apparatus decreases the amount of power used in computer and computer peripheral devices by utilizing a switching transistor which is set into switching operation responsive to a pulse signal received from a power source control circuit. This switching transistor controls the voltage applied to the primary winding of the power transformer by the switching transistor, and issues an output voltage from the secondary winding. The power supply apparatus includes a switch circuit which is connected in series to the starting resistor for supplying the output voltage rectified from the AC power source when starting up to the power supply control circuit. The power supply apparatus includes a switch control circuit which turns off the switch circuit when the output voltage rectified from the AC output of the tertiary winding of the power transformer reaches a voltage high enough for stable operation of the power supply control circuit. As a result, the power loss at the starting resistor is curtailed after startup of the switching type power supply apparatus such that the power consumption of the power-saving operation is also curtailed.

    摘要翻译： 开关型电源装置通过利用响应于从电源控制电路接收的脉冲信号而被设置为开关操作的开关晶体管来减少计算机和计算机外围设备中使用的功率量。 该开关晶体管通过开关晶体管控制施加到电力变压器的初级绕组的电压，并且从次级绕组发出输出电压。 电源装置包括开关电路，该开关电路与起动电阻器串联连接，用于在启动电源控制电路时提供从交流电源整流的输出电压。 电源装置包括开关控制电路，当从电力变压器的三次绕组的AC输出整流的输出电压达到足够高的电压以使电源控制电路的稳定工作时，断开开关电路。 结果，启动电阻器的启动之后的功率损耗在开关型电源装置启动之后被削减，使得省电操作的功耗也被削减。

    Linear bearing
    5.
    发明授权
    Linear bearing 失效
    线性轴承

    公开(公告)号：US5236264A

    公开(公告)日：1993-08-17

    申请号：US895371

    申请日：1992-06-09

    申请人： Toshio Matsubara ,  Takeo Koyama ,  Magozo Hamamoto ,  Shoichiro Koike

    发明人： Toshio Matsubara ,  Takeo Koyama ,  Magozo Hamamoto ,  Shoichiro Koike

    IPC分类号： F16C29/04

    CPC分类号： F16C33/40 ,  F16C29/04

    摘要： A linear bearing is constructed of a shaft having a cylindrical outer wall, an outer race having a cylindrical inner peripheral wall, a cylindrical retainer inserted for axial displacement within a toroidal space between the outer wall and the inner wall, and plural balls retained for rotation in the retainer and in contact with the outer wall and the inner wall. The balls are provided more densely at axially opposite end portions of the retainer.

    摘要翻译： 线性轴承由具有圆柱形外壁的轴，具有圆柱形内周壁的外圈构成，插入在外壁和内壁之间的环形空间内的轴向位移的圆柱形保持器，以及保持旋转的多个滚珠 在保持器中并与外壁和内壁接触。 滚珠在保持器的轴向相对的端部处更密集地设置。

    Game machine
    6.
    发明授权
    Game machine 有权
    游戏机

    公开(公告)号：US06325720B1

    公开(公告)日：2001-12-04

    申请号：US09190134

    申请日：1998-11-12

    申请人： Nakayasu Tsukahara ,  Mitsuaki Kusanagi ,  Takeo Koyama

    发明人： Nakayasu Tsukahara ,  Mitsuaki Kusanagi ,  Takeo Koyama

    IPC分类号： A63F924

    CPC分类号： G07F17/3209 ,  G07F17/32

    摘要： A game machine comprises a housing, a lever pivotally supported on the housing and a control unit. The lever comprises a rod portion having a handle portion integrally formed at the front section and a sensor actuating portion integrally formed at the rear section. The game machine comprises a resiliently urging member for resiliently urging the rod portion toward a neutral position from first and second positions. The game machine further comprises first and second optical sensors positioned to have the lights intercepted by the sensor actuating portion of the lever when the rod portion of the lever is moved to the first and second positions, respectively. The control unit is operable to selectively perform predetermined first and second operations in accordance with signals outputted from the first and second optical sensors, respectively.

    摘要翻译： 游戏机包括壳体，枢轴地支撑在壳体上的杆和控制单元。 杠杆包括杆部分，其具有一体地形成在前部的手柄部分和在后部一体形成的传感器致动部分。 游戏机包括弹性推动构件，用于将杆部分从第一和第二位置弹性地推向中立位置。 所述游戏机还包括第一和第二光学传感器，所述第一和第二光学传感器被定位成当所述杆的杆部分分别移动到所述第一和第二位置时，所述光被所述杠杆的传感器致动部分截取。 控制单元可操作以分别根据从第一和第二光学传感器输出的信号选择性地执行预定的第一和第二操作。

    Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives
    7.
    发明授权
    Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives 失效
    2-苯基-3-萘基丙酸衍生物的制备方法

    公开(公告)号：US06252088B1

    公开(公告)日：2001-06-26

    申请号：US09147785

    申请日：1999-03-08

    申请人： Yukio Yokoyama ,  Tatsuya Kobayashi ,  Takeo Koyama

    发明人： Yukio Yokoyama ,  Tatsuya Kobayashi ,  Takeo Koyama

    IPC分类号： C07D20712

    CPC分类号： C07C255/50 ,  C07C253/30 ,  C07D207/12 ,  Y02P20/55 ,  C07C255/52

    摘要： A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1 represents a protective group for a nitrogen atom; R2 represents a methanesulfonyl group or p-toluenesulfonyl group; R3 represents a hydrogen atom, an aralkyl group, or an alkyl group having 1 to 6 carbon atoms; and X represents a halogen atom. The above process is useful as an industrial process for preparing intermediates of anticoagulant aromatic amidine derivatives described in Japanese Patent Application Laid-Open (kokai) No. 208946/1993.

    摘要翻译： 在下列反应方案中制备由通式（5）和（6）表示的化合物或其盐的方法，其中R 1表示氮原子的保护基; R2表示甲磺酰基或对甲苯磺酰基; R3表示氢原子，芳烷基或碳原子数1〜6的烷基。 并且X表示卤素原子。上述方法可用作制备日本专利申请公开（kokai）208946/1993中描述的抗凝血性芳族脒衍生物的中间体的工业方法。

    Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives
    9.
    发明授权
    Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives 失效
    2-苯基-3-萘基丙酸衍生物的制备方法

    公开(公告)号：US06337405B1

    公开(公告)日：2002-01-08

    申请号：US09742348

    申请日：2000-12-22

    申请人： Yukio Yokoyama ,  Tatsuya Kobayashi ,  Takeo Koyama

    发明人： Yukio Yokoyama ,  Tatsuya Kobayashi ,  Takeo Koyama

    IPC分类号： C07D20708

    CPC分类号： C07C255/50 ,  C07C253/30 ,  C07D207/12 ,  Y02P20/55 ,  C07C255/52

    摘要： A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1 represents a protective group for a nitrogen atom; R2 represents a methanesulfonyl group or p-toluenesulfonyl group; R3 represents a hydrogen atom, an aralkyl group, or an alkyl group having 1 to 6 carbon atoms; and X represents a halogen atom. Reaction Scheme: The above process is useful as an industrial process for preparing intermediates of anticoagulant aromatic amidine derivatives described in Japanese Patent Application Laid-Open (kokai) No. 208946/1993.

    摘要翻译： 在下列反应方案中制备由通式（5）和（6）表示的化合物或其盐的方法，其中R 1表示氮原子的保护基; R2表示甲磺酰基或对甲苯磺酰基; R3表示氢原子，芳烷基或碳原子数1〜6的烷基。 X表示卤素原子。 反应方案：上述方法可用作制备日本专利申请公开（kokai）208946/1993中所述的抗凝血芳香族脒衍生物的中间体的工业方法。