公开(公告)号：US08512949B2

公开(公告)日：2013-08-20

申请号：US12996420

申请日：2009-06-10

申请人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Hideki Naganishi

发明人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Hideki Naganishi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/178

摘要： Disclosed are: a method for using a particular microRNA as a biomarker for head-and-neck tumor; a method for the determination of head-and-neck tumor; a kit for the determination of head-and-neck tumor, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21, miR-31, miR-133b, miR-145 and miR-375 is used as a biomarker for head-and-neck tumor.

摘要翻译： 公开的是：使用特定的微RNA作为头颈部肿瘤的生物标志物的方法; 一种确定头颈部肿瘤的方法; 用于确定头颈部肿瘤的试剂盒等。 本发明的特征在于，选自miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR- 21，miR-31，miR-133b，miR-145和miR-375用作头颈部肿瘤的生物标志物。

公开(公告)号：US20110143950A1

公开(公告)日：2011-06-16

申请号：US12996420

申请日：2009-06-10

申请人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Hideki Naganishi

发明人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Hideki Naganishi

IPC分类号： C40B30/00 ,  C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/178

摘要： Disclosed are: a method for using a particular microRNA as a biomarker for head-and-neck tumor; a method for the determination of head-and-neck tumor; a kit for the determination of head-and-neck tumor, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21, miR-31, miR-133b, miR-145 and miR-375 is used as a biomarker for head-and-neck tumor.

摘要翻译： 公开的是：使用特定的微RNA作为头颈部肿瘤的生物标志物的方法; 一种确定头颈部肿瘤的方法; 用于确定头颈部肿瘤的试剂盒等。 本发明的特征在于，选自miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR- 21，miR-31，miR-133b，miR-145和miR-375用作头颈部肿瘤的生物标志物。

公开(公告)号：US20120088816A1

公开(公告)日：2012-04-12

申请号：US13263800

申请日：2010-04-16

申请人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

发明人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

IPC分类号： A61K31/713 ,  A61P35/00 ,  A61P35/04 ,  C07H21/02

CPC分类号： A61K31/7088 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141

摘要： It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

摘要翻译： 它提供了一种新型的头颈部肿瘤增殖抑制剂，头颈部肿瘤转移抑制剂和用于治疗头颈部肿瘤的药物组合物。 本发明的特征在于使用在头颈部肿瘤中其表达降低的头颈部肿瘤和/或其表达降低的促进物质的微小RNA的抑制物质。 在头颈部肿瘤中表达增加的微小RNA的优选实例包括miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR-21和 miR-31。 在头颈部肿瘤中表达降低的微小RNA的优选实例包括miR-133b，miR-145和miR-375。

公开(公告)号：US20110166041A1

公开(公告)日：2011-07-07

申请号：US12999124

申请日：2009-06-25

申请人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

发明人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

IPC分类号： C40B40/06 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Disclosed are: a method for using a particular microRNA as a biomarker for gynecological cancer; a method for the determination of gynecological cancer; a kit for the determination of gynecological cancer, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-592, miR-629*, miR-517a, miR-205, miR-184, miR-509-5p, miR-135a*, miR-137, miR-602, miR-186*, miR-181a-2*, miR-193b*, miR-377*, miR-449b, miR-449a, miR-369-3p, miR-323-3p, miR-329, miR-299-5p, miR-34b, miR-411, miR-34c-5p, miR-376b, miR-885-5p, miR-337-3p, miR-337-5p, miR-127-3p, miR-138, miR-203, miR-488, miR-489, miR-643, miR-888, miR-424, miR-432, miR-433, miR-450a, miR-503, miR-542-3p, miR-542-5p and miR-584 is used as a biomarker for gynecological cancer.

摘要翻译： 公开的是：使用特定微小RNA作为妇科癌症生物标志物的方法; 确定妇科癌症的方法; 用于确定妇科癌症的试剂盒等。 本发明的特征在于，至少一种选自miR-592，miR-629 *，miR-517a，miR-205，miR-184，miR-509-5p，miR-135a * ，miR-137，miR-602，miR-186 *，miR-181a-2 *，miR-193b *，miR-377 *，miR-449b，miR-449a，miR-369-3p，miR-323-3p ，miR-329，miR-299-5p，miR-34b，miR-411，miR-34c-5p，miR-376b，miR-885-5p，miR-337-3p，miR-337-5p，miR-127 -3p，miR-138，miR-203，miR-488，miR-489，miR-643，miR-888，miR-424，miR-432，miR-433，miR-450a，miR-503，miR-542 -3p，miR-542-5p和miR-584用作妇科癌症的生物标志物。

公开(公告)号：US08420800B2

公开(公告)日：2013-04-16

申请号：US13263800

申请日：2010-04-16

申请人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

发明人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00

CPC分类号： A61K31/7088 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141

摘要： It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

摘要翻译： 它提供了一种新型的头颈部肿瘤增殖抑制剂，头颈部肿瘤转移抑制剂和用于治疗头颈部肿瘤的药物组合物。 本发明的特征在于使用在头颈部肿瘤中其表达降低的头颈部肿瘤和/或其表达降低的促进物质的microRNA的抑制物质。 在头颈部肿瘤中表达增加的微小RNA的优选实例包括miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR-21和 miR-31。 在头颈部肿瘤中表达降低的微小RNA的优选实例包括miR-133b，miR-145和miR-375。

公开(公告)号：US20080041545A1

公开(公告)日：2008-02-21

申请号：US11973695

申请日：2007-10-09

申请人： Akira Hirasawa

发明人： Akira Hirasawa

IPC分类号： D21H17/00

CPC分类号： D21H21/22 ,  A47K10/16 ,  D21H21/14 ,  D21H21/38 ,  D21H27/002

摘要： It is intended to provide sanitary paper which is excellent in texture such as moistness and softness and scarcely causes skin irritation or blushing even if it is brought into contact with the skin frequently. Namely, sanitary paper having an oil absorbance specified in JIS P8141 of 7 mm or less and a moisture content of from 9.50 to 15.00% (measured in accordance with JIS P8127 after conditioning in accordance with JIS P8111); carrying a solution, which contains a moistening agent, a softener, an antioxidant and so on, coated in a dose of 46.0 to 160.0 mg/cm3 of the paper base; and having a bending hardness B measured with the use of a pure bending machine of from 0.0040 to 0.0060 g·cm2/cm.

摘要翻译： 本发明提供湿润柔软等质地优异的卫生纸，即使经常与皮肤接触，也几乎不引起皮肤刺激或白化。 即，JIS P8141中规定的吸油量为7mm以下，湿度为9.50〜15.00％（根据JIS P8127，按照JIS P8111调理后测定）的卫生纸; 携带含有作为纸基的46.0〜160.0mg / cm3的剂量的润湿剂，软化剂，​​抗氧化剂等的溶液。 并且具有使用纯度为0.0040至0.0060克/厘米2厘米的纯弯曲机测得的弯曲硬度B。

公开(公告)号：US20080004227A1

公开(公告)日：2008-01-03

申请号：US10591186

申请日：2004-09-03

申请人： Akira Hirasawa ,  Gozo Tsujimoto

发明人： Akira Hirasawa ,  Gozo Tsujimoto

IPC分类号： A61K48/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/00 ,  C12N15/00 ,  G01N33/566

CPC分类号： C07K14/605 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/042

摘要： An object of the invention is to provide a pharmaceutical composition and a kit therefor for the lowering of elevated blood sugar level associated with diabetes and for the prevention of the elevation of blood sugar level. The invention provides a pharmaceutical composition containing a ligand (agonist or antagonist) for a GT01 polypeptide, particularly a free fatty acid as a GT01 polypeptide-specific ligand, or a GT01 gene or the GT01 polypeptide, for treating the hyperglycemia associated with diabetes, and a kit therefor. The invention also provides a ligand specific for the GT01 polypeptide, and a screening method exerting an influence on the binding of the specific ligand to the GT01 polypeptide.

摘要翻译： 本发明的目的是提供一种药物组合物及其用于降低与糖尿病相关的升高的血糖水平和用于预防血糖水平升高的试剂盒。 本发明提供一种药物组合物，其含有用于治疗与糖尿病相关的高血糖症的GT01多肽，特别是游离脂肪酸作为GT01多肽特异性配体或GT01基因或GT01多肽的配体（激动剂或拮抗剂），以及 一个工具包。 本发明还提供了对GT01多肽特异性的配体，以及对特异性配体与GT01多肽的结合产生影响的筛选方法。

公开(公告)号：US5646203A

公开(公告)日：1997-07-08

申请号：US413690

申请日：1995-03-30

申请人： Kei Etoh ,  Akira Hirasawa ,  Hisano Higurashi ,  Makoto Kawamura

发明人： Kei Etoh ,  Akira Hirasawa ,  Hisano Higurashi ,  Makoto Kawamura

IPC分类号： B41M5/165 ,  B41M5/28 ,  C09D11/02 ,  C08K5/053 ,  B32B5/18 ,  C08J9/32 ,  C08K7/22

CPC分类号： C09D11/02 ,  B41M5/165 ,  B41M5/287 ,  Y10T428/249997 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989

摘要： A microcapsule-containing oil-based coating liquid wherein the coating liquid comprises a hydrophobic core material-containing microcapsule particles dispersed individually in a state of primary particle in an oil varnish for ink use or a resin for coating use, and a solvent having an affinity for both the varnish or the resin and the surface of the microcapsule wall material in a state of having been attracted with the affinity to both the varnish or the resin and the surface layer of the microcapsule wall material. The preferred solvent is a lower divalent or multivalent alcohol.A preparative method of the foregoing coating liquid by utilizing vacuum distillation is also proposed.A sheet, like a duplicating sheet of paper coated with the foregoing oil-based coating liquid is further provided.According to the present invention, a water-based microcapsules system can be advantageously converted into an oil-based one without coagulating the primary microcapsule particles. There is no hardening and breakdown of the wall material during the process, and the original strength and the flexibility of the microcapsule wall material can be retained intact. Conventional pressure transferring-type printing machine may be employed to printing a selected area of the sheet.

摘要翻译： 一种含微胶囊的油性涂布液，其中，所述涂布液包含分散在油墨用油性油墨中的一次粒子状态的分散的含疏水性芯材料的微胶囊粒子，或者涂布用树脂，以及具有亲和性的溶剂 对于清漆或树脂以及微胶囊壁材料的表面以与清漆或树脂和微胶囊壁材料的表面层的亲和性吸引的状态。 优选的溶剂是低级二价或多价醇。 还提出了通过利用真空蒸馏的上述涂布液的制备方法。 进一步提供如同涂覆有上述油性涂料的复印纸一样的片材。 根据本发明，可以有利地将水性微胶囊体系转化为油性微胶囊体系而不使一级微胶囊颗粒凝结。 在该过程中没有壁材料的硬化和分解，并且微胶囊壁材料的原始强度和柔韧性可以保持完整。 传统的压力传送型印刷机可用于印刷片材的选定区域。

公开(公告)号：US09338855B2

公开(公告)日：2016-05-10

申请号：US14241847

申请日：2011-08-31

申请人： Akira Hirasawa ,  Yuhki Terao

发明人： Akira Hirasawa ,  Yuhki Terao

IPC分类号： H01L27/32 ,  H05B33/08

CPC分类号： H05B33/0896 ,  H01L27/3211 ,  H01L2251/5361 ,  H05B33/0857

摘要： A lighting apparatus includes: a plurality of light emission units that respectively emit lights in luminescent colors different from each other; and a control unit that controls in luminance the respective light, which are emitted from said plurality of light emission units, for the respective luminescent colors. In response to a control input, said control unit switches between a first light emission mode that it makes said light emission units emit light with luminance set for the respective luminescent colors and a second light emission mode that makes it light emission units corresponding to at least one luminescent color turn off or emit light with luminance lower than the luminance in the first light emission mode.

摘要翻译： 照明装置包括：多个发光单元，其分别发射彼此不同的发光颜色的光; 以及控制单元，其控制从所述多个发光单元发射的各个发光颜色的各个亮度的亮度。 响应于控制输入，所述控制单元在其使得所述发光单元发光的第一发光模式与针对各个发光颜色设定的亮度之间切换，并且使其使得至少对应于发光单元的第二发光模式 一种发光颜色在亮度低于第一发光模式下的亮度时熄灭或发光。

公开(公告)号：US20080252204A1

公开(公告)日：2008-10-16

申请号：US11887411

申请日：2006-03-30

申请人： Ayako Yoshida ,  Akira Hirasawa ,  Satoshi Miyaguchi

发明人： Ayako Yoshida ,  Akira Hirasawa ,  Satoshi Miyaguchi

IPC分类号： H01L51/54 ,  B32B38/16

CPC分类号： H05B33/28 ,  H01L27/3244 ,  H01L27/3281 ,  H01L51/5203 ,  H01L51/5209 ,  H01L51/5218 ,  H01L51/5225 ,  H01L51/5237 ,  H01L2251/5315 ,  H05B33/22

摘要： An organic EL device of top emission type having a structure of a transparent conductive layer on a metal reflecting layer, and particularly an organic EL device having a high luminance with the stability capable of maintaining the high luminance over the long period of time is provided. The organic EL device includes a metal electrode layer serving as a metal reflecting film, a transparent conductive layer, an organic functional layer having an organic EL layer, and a transparent electrode layer which are successively laminated on a substrate, and a formation area of the metal electrode layer resides inside a protection area where the transparent conductive layer is formed on the substrate.

摘要翻译： 提供了一种在金属反射层上具有透明导电层结构的顶部发射型有机EL器件，特别是具有能够长时间保持高亮度的稳定性的具有高亮度的有机EL器件。 有机EL器件包括用作金属反射膜的金属电极层，透明导电层，具有有机EL层的有机功能层和依次层压在基板上的透明电极层，以及形成区域 金属电极层位于在基板上形成透明导电层的保护区域的内部。