公开(公告)号：US5651884A

公开(公告)日：1997-07-29

申请号：US469731

申请日：1995-06-06

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Katsumi Kawamura ,  Masaya Sumita ,  Akihiko Yokoo

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Katsumi Kawamura ,  Masaya Sumita ,  Akihiko Yokoo

IPC分类号： B01D15/08 ,  B01J20/04 ,  B01J20/32

CPC分类号： B01J20/28059 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3021 ,  B01J20/3028 ,  B01J20/3064 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/58

摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense stricture with a porosity of no more than 5%.A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2-2x F.sub.2x (I)wherein x is a number of from about 0.1 to 1.

摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种柱状填充材料，其由在其表面上具有磷酸钙基化合物的涂层的球形基材构成。 本发明的第二方面涉及一种包含多孔磷酸钙基颗粒的包装材料，其具有平均孔径为0.01至20μm的开放孔，所述颗粒由平均尺寸为0.1-10μm的结晶颗粒组成 。 本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3） 2，Ca10（PO4）6F2和Ca10（PO4）6Cl2，所述包装材料具有密度不大于5％的密度。 本发明的第四方面涉及一种用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：Ca10（PO4）6（OH）2-2xF2x（I），其中x是 约0.1至1。

公开(公告)号：USRE35340E

公开(公告)日：1996-10-01

申请号：US105850

申请日：1993-08-13

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Katsumi Kawamura ,  Masaya Sumita ,  Akihiko Yokoo

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Katsumi Kawamura ,  Masaya Sumita ,  Akihiko Yokoo

IPC分类号： B01J20/04 ,  B01D15/08

CPC分类号： G01N30/482 ,  B01J20/048 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28054 ,  B01J20/28078 ,  B01J20/28095 ,  B01J20/282 ,  B01J20/283 ,  B01J20/3021 ,  B01J20/3078 ,  B01J20/3204 ,  B01J20/3236 ,  B01J2220/54

摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense structure with a porosity of no more than 5%.A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2-2x F.sub.2x (I)wherein x is a number of from about 0.1 to 1.

摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种柱状填充材料，其由在其表面上具有磷酸钙基化合物的涂层的球形基材构成。 本发明的第二方面涉及一种包含多孔磷酸钙基颗粒的包装材料，其具有平均孔径为0.01至20μm的开放孔，所述颗粒由平均尺寸为0.1-10μm的结晶颗粒组成 。 本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3） 2，Ca10（PO4）6F2和Ca10（PO4）6Cl2，所述包装材料具有孔隙率不超过5％的致密结构。 本发明的第四方面涉及一种用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：Ca10（PO4）6（OH）2-2xF2x（I），其中x是 约0.1至1。

公开(公告)号：US06306297B1

公开(公告)日：2001-10-23

申请号：US08371205

申请日：1995-01-11

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

IPC分类号： B01D1508

CPC分类号： B01J20/28059 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3021 ,  B01J20/3064 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/58

摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof. A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 &mgr;m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 &mgr;m. A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca10(PO4)6(OH)2, Ca3(PO4)2, Ca2P2O7, Ca(PO3)2, Ca10(PO4)6F2 and Ca10(PO4)6Cl2, said packing material having a dense structure with a porosity of no more than 5%. A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I): Ca10(PO4)6(OH)2−2xF2x  (I) wherein x is a number of from about 0.1 to 1.

摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种由包含磷酸钙基化合物的表面的球状基材构成的柱状填充材料。本发明的第二方面涉及包含多孔磷酸钙基颗粒的填充材料，该颗粒具有开孔， 平均孔径为0.01至20μm，所述颗粒由平均尺寸为0.1至10μm的结晶颗粒组成。本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括至少一种 选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3）2，Ca10（PO4）6F2和Ca10（PO4）6Cl2）组成的材料，所述包装材料具有致密结构 孔隙率不超过5％。本发明的第四方面涉及用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：其中x是 数量从大约0.1到1。

公开(公告)号：US5039408A

公开(公告)日：1991-08-13

申请号：US461854

申请日：1990-01-08

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo ,  Katsumi Kawamura

IPC分类号： B01D15/08 ,  B01J20/04 ,  B01J20/32

CPC分类号： B01J20/28083 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3236 ,  B01J2220/54

摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense structure with a porosity of no more than 5%.A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2-2x F.sub.2x (I)wherein x is a number of from about 0.1 to 1.

摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种柱状填充材料，其由在其表面上具有磷酸钙基化合物的涂层的球形基材构成。 本发明的第二方面涉及一种包含多孔磷酸钙基颗粒的包装材料，其具有平均孔径为0.01至20μm的开放孔，所述颗粒由平均尺寸为0.1-10μm的结晶颗粒组成 。 本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3） 2，Ca10（PO4）6F2和Ca10（PO4）6Cl2，所述包装材料具有孔隙率不超过5％的致密结构。 本发明的第四方面涉及一种用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：Ca10（PO4）6（OH）2-2xF2x（I），其中x是 约0.1至1。

公开(公告)号：US5240659A

公开(公告)日：1993-08-31

申请号：US857638

申请日：1992-03-24

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B35/447 ,  C04B35/634

CPC分类号： C04B35/447 ,  A61L27/12 ,  C04B35/634 ,  A61F2310/00293

摘要： An oriented shaped article of a calcium phosphate type compound is disclosed, in which at least two crystallographic axes of the primary particles of which the shaped article is composed each is oriented in one direction, respectively, in at least the surface of said article. A sinter of the oriented shaped article and a processes for producing the article and the sinter are also disclosed.

摘要翻译： 公开了一种磷酸钙型化合物的取向成型制品，其中至少两个成型制品的一次颗粒的结晶轴分别在至少所述制品的表面上沿一个方向取向。 还公开了定向成型制品的烧结体以及制造制品和烧结体的方法。

公开(公告)号：US5134009A

公开(公告)日：1992-07-28

申请号：US407009

申请日：1989-09-14

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita ,  Akihiko Yokoo

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61L27/12 ,  C04B35/447 ,  C04B35/634 ,  C04B35/636 ,  C04B35/638

CPC分类号： C04B35/63416 ,  A61L27/12 ,  C04B35/447 ,  C04B35/634 ,  C04B35/63424 ,  C04B35/6365 ,  C04B35/638 ,  A61F2310/00293 ,  Y10T428/24058 ,  Y10T428/24124 ,  Y10T428/249921 ,  Y10T428/2927 ,  Y10T428/2929

摘要： An oriented shaped article of a calcium phosphate type compound is disclosed, in which at least two crystallographic axes of the primary particles of which the shaped article is composed each is oriented in one direction, respectively, in at least the surface of said article. A sinter of the oriented shaped article and a processes for producing the article and the sinter are also disclosed.

公开(公告)号：US5651882A

公开(公告)日：1997-07-29

申请号：US371378

申请日：1995-01-11

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Katsumi Kawamura ,  Akihiko Yokoo

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Katsumi Kawamura ,  Akihiko Yokoo

IPC分类号： B01D15/08 ,  B01J20/04 ,  B01J20/32

CPC分类号： B01J20/28059 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3021 ,  B01J20/3028 ,  B01J20/3064 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/58

摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense structure with a porosity of no more than 5%.A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2-2x F.sub.2x (I)wherein x is a number of from about 0.1 to 1.

摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种柱状填充材料，其由在其表面上具有磷酸钙基化合物的涂层的球形基材构成。 本发明的第二方面涉及一种包含多孔磷酸钙基颗粒的包装材料，其具有平均孔径为0.01至20μm的开放孔，所述颗粒由平均尺寸为0.1-10μm的结晶颗粒组成 。 本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3） 2，Ca10（PO4）6F2和Ca10（PO4）6Cl2，所述包装材料具有孔隙率不超过5％的致密结构。 本发明的第四方面涉及一种用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：Ca10（PO4）6（OH）2-2xF2x（I），其中x是 约0.1至1。

公开(公告)号：US5441635A

公开(公告)日：1995-08-15

申请号：US29940

申请日：1993-03-10

申请人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita

发明人： Takeshi Ichitsuka ,  Tetsuro Ogawa ,  Masaya Sumita

IPC分类号： B01D15/08 ,  B01J20/04 ,  B01J20/32

CPC分类号： B01J20/28059 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3021 ,  B01J20/3028 ,  B01J20/3064 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/58

摘要： Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense structure with a porosity of no more than 5%.A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2-2x F.sub.2x (I)wherein x is a number of from about 0.1 to 1.

摘要翻译： 描述了可用于诸如液相色谱法的应用的柱状填料，以及用于生产这种包装材料的方法。 本发明的第一方面涉及一种柱状填充材料，其由在其表面上具有磷酸钙基化合物的涂层的球形基材构成。 本发明的第二方面涉及一种包含多孔磷酸钙基颗粒的包装材料，其具有平均孔径为0.01至20μm的开放孔，所述颗粒由平均尺寸为0.1-10μm的结晶颗粒组成 。 本发明的第三方面涉及一种用于液相色谱的球形包装材料，其包括选自Ca10（PO4）6（OH）2，Ca3（PO4）2，Ca2P2O7，Ca（PO3） 2，Ca10（PO4）6F2和Ca10（PO4）6Cl2，所述包装材料具有孔隙率不超过5％的致密结构。 本发明的第四方面涉及一种用于液相色谱的填料，其包括至少在其表面上具有由式（I）表示的氟磷灰石的颗粒：Ca10（PO4）6（OH）2-2xF2x（I），其中x是 约0.1至1。

公开(公告)号：US5158756A

公开(公告)日：1992-10-27

申请号：US543047

申请日：1990-06-25

申请人： Tetsuro Ogawa ,  Akihiko Yokoo ,  Kazuhiro Naganuma ,  Satoshi Fujinuma ,  Katsumi Kawamura

发明人： Tetsuro Ogawa ,  Akihiko Yokoo ,  Kazuhiro Naganuma ,  Satoshi Fujinuma ,  Katsumi Kawamura

IPC分类号： B01J20/281 ,  B01D15/08 ,  B01J20/04 ,  C01B25/32 ,  C04B38/00 ,  G01N30/88

CPC分类号： B01J20/048 ,  B01J20/282 ,  C01B25/322 ,  C04B38/009

摘要： Porous particles of a calcium phosphate compound having a Ca/P ratio of 1.5 to 1.80, which contain open pores having an average pore size of 100 to 4000 .ANG. and are in the form of spherical particles having an average particle size of 1 to 40 .mu.m, and a process for their production. 90% of the total pore volume of the particles is occupied by pores having a pore size that is 0.5 to 2 times larger than the average pore size of the open pores and the total volume is at least 0.5 ml/g of the particles. The porous calcium phosphate particles are particularly useful as packings for liquid chromatography.

摘要翻译： Ca / P比为1.5〜1.80的磷酸钙化合物的多孔粒子，其含有平均孔径为100〜4000的开孔，为平均粒径为1〜40μm的球状粒子 m，以及一个生产过程。 颗粒的总孔体积的90％被孔的孔隙占开孔的平均孔径的0.5〜2倍，总体积为0.5ml / g以上。 多孔磷酸钙颗粒特别适用于液相色谱填充。

公开(公告)号：US5064436A

公开(公告)日：1991-11-12

申请号：US373708

申请日：1989-07-03

申请人： Makoto Ogiso ,  Tetsuro Ogawa ,  Takeshi Ichitsuka ,  Masahide Inoue

发明人： Makoto Ogiso ,  Tetsuro Ogawa ,  Takeshi Ichitsuka ,  Masahide Inoue

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61K6/033 ,  A61L27/12 ,  A61L27/56 ,  C04B38/00

CPC分类号： C04B38/009 ,  A61L27/12 ,  A61L27/56 ,  A61F2310/00293

摘要： A bone prosthetic material composed of calcium phosphate group granules which have open cells with an average pore size of 0.01-(10 .mu.m).sup.2 over a surface density of at least one per 10 .mu.m.sup.2. The prosthetic material is prepared by mixing organic inflammable particles with a calcium based powder, granulating and then firing the mixture.

摘要翻译： 由具有平均孔径为0.011-（10μm）的开孔的磷酸钙颗粒组成的骨修复材料，其表面密度至少为每10平方米至少1个。 通过将有机易燃颗粒与钙基粉末混合，制粒然后烧结混合物来制备假体材料。