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    Preparation of alicyclic diepoxides
    3.
    发明授权
    Preparation of alicyclic diepoxides 失效
    脂环族二环氧化物的制备

    公开(公告)号：US08389752B2

    公开(公告)日：2013-03-05

    申请号：US12577845

    申请日：2009-10-13

    申请人： Andrew Bell ,  Dane Jablonski ,  Elaine Koronich ,  Yumiko Yamanoi ,  Yoshiaki Fukunishi ,  Kazunobu Senoo

    发明人： Andrew Bell ,  Dane Jablonski ,  Elaine Koronich ,  Yumiko Yamanoi ,  Yoshiaki Fukunishi ,  Kazunobu Senoo

    IPC分类号： C07D301/03 ,  C07D303/00

    CPC分类号： C07D405/04 ,  C07D405/06 ,  C07D405/08

    摘要： Embodiments in accordance with the present invention provide alicyclic diepoxide compounds and methods for forming such compounds. Such methods encompass charging a reaction vessel with an appropriate diene and an appropriate dienophile and causing such to react to form and recover a desired alicyclic diepoxide precursor where such precursor is subsequently epoxidized. Such compounds encompass alicyclic diepoxides having purities of at least 95 percent or at least 98 percent with respect non-isomeric residues and are essentially free of any isomeric alicyclic diepoxide residues.

    摘要翻译： 根据本发明的实施方案提供了脂环族二环氧化合物及其形成方法。 这样的方法包括用合适的二烯和适当的亲二烯体装载反应容器并使其反应以形成和回收所需的脂环族二环氧化物前体，其中这种前体随后被环氧化。 这样的化合物包括相对于非异构残基具有至少95％或至少98％的纯度的脂环族二环氧化物，并且基本上不含任何异构的脂环族二环氧化物残基。

    Preparation Of Alicyclic Diepoxides
    4.
    发明申请
    Preparation Of Alicyclic Diepoxides 失效
    脂环族二环氧化物的制备

    公开(公告)号：US20100094030A1

    公开(公告)日：2010-04-15

    申请号：US12577845

    申请日：2009-10-13

    申请人： Andrew Bell ,  Dane Jablonski ,  Elaine Koronich ,  Yumiko Yamanoi ,  Yoshiaki Fukunishi ,  Kazunobu Senoo

    发明人： Andrew Bell ,  Dane Jablonski ,  Elaine Koronich ,  Yumiko Yamanoi ,  Yoshiaki Fukunishi ,  Kazunobu Senoo

    IPC分类号： C07D303/06 ,  C07D301/03

    CPC分类号： C07D405/04 ,  C07D405/06 ,  C07D405/08

    摘要： Embodiments in accordance with the present invention provide alicyclic diepoxide compounds and methods for forming such compounds. Such methods encompass charging a reaction vessel with an appropriate diene and an appropriate dienophile and causing such to react to form and recover a desired alicyclic diepoxide precursor where such precursor is subsequently epoxidized. Such compounds encompass alicyclic diepoxides having purities of at least 95 percent or at least 98 percent with respect non-isomeric residues and are essentially free of any isomeric alicyclic diepoxide residues.

    摘要翻译： 根据本发明的实施方案提供了脂环族二环氧化合物及其形成方法。 这样的方法包括用合适的二烯和适当的亲二烯体装载反应容器并使其反应以形成和回收所需的脂环族二环氧化物前体，其中这种前体随后被环氧化。 这样的化合物包括相对于非异构残基具有至少95％或至少98％的纯度的脂环族二环氧化物，并且基本上不含任何异构的脂环族二环氧化物残基。

    SULFATED POLYSACCHARIDE CAPABLE OF BINDING TO GROWTH FACTOR AND USE THEREOF
    6.
    发明申请
    SULFATED POLYSACCHARIDE CAPABLE OF BINDING TO GROWTH FACTOR AND USE THEREOF 审中-公开
    硫化多糖配合生长因子及其用途

    公开(公告)号：US20130157303A1

    公开(公告)日：2013-06-20

    申请号：US13819973

    申请日：2011-08-31

    申请人： Yoshiaki Fukunishi ,  Yasuhiko Tabata

    发明人： Yoshiaki Fukunishi ,  Yasuhiko Tabata

    IPC分类号： C08B37/00

    CPC分类号： C08B37/00 ,  A61K31/737 ,  C08B37/0003 ,  C08B37/006 ,  C12P19/04 ,  G01N33/74 ,  G01N2400/40 ,  G01N2800/7023

    摘要： A biological substance which can enhance the proliferation and differentiation of cells; a method for evaluating the proliferation and differentiation of cells, which targets the biological substance; a composition for detecting the proliferation and differentiation of cells, which contains a molecule capable of binding to the biological substance; and a composition for enhancing the proliferation and differentiation of cells, which contains the biological substance. A part of a sulfated polysaccharide secreted from cells binds to a growth factor during the course of the proliferation and differentiation of the cells, that the amount of the sulfated polysaccharide capable of the above-mentioned binding and secreted from the cells correlates strongly with the progression of the proliferation and differentiation of the cells, and that the proliferation and differentiation of cells can be evaluated and the proliferation and differentiation of cells can be enhanced utilizing the sulfated polysaccharide.

    摘要翻译： 可增强细胞增殖和分化的生物物质; 用于评估靶向生物物质的细胞增殖和分化的方法; 用于检测细胞增殖和分化的组合物，其含有能够结合生物物质的分子; 以及用于增强含有生物物质的细胞的增殖和分化的组合物。 从细胞分泌的一部分硫酸化多糖在细胞增殖和分化过程中与生长因子结合，能够上述结合并从细胞分泌的硫酸化多糖的量与进展强烈相关 的细胞的增殖和分化，并且可以评估细胞的增殖和分化，并且可以利用硫酸化多糖来增强细胞的增殖和分化。

    PARTICLE FOR MEDICAL USE, PARTICLE FOR ANLAYSIS AND METHOD OF PRODUCING THE SAME
    7.
    发明申请
    PARTICLE FOR MEDICAL USE, PARTICLE FOR ANLAYSIS AND METHOD OF PRODUCING THE SAME 审中-公开
    用于医疗用途的颗粒，用于环境的颗粒及其生产方法

    公开(公告)号：US20100062475A1

    公开(公告)日：2010-03-11

    申请号：US12448681

    申请日：2008-01-11

    申请人： Yuzo Hamaguchi ,  Sohei Funaoka ,  Yoshiaki Fukunishi ,  Tayuki Matsumoto

    发明人： Yuzo Hamaguchi ,  Sohei Funaoka ,  Yoshiaki Fukunishi ,  Tayuki Matsumoto

    IPC分类号： C12Q1/02 ,  B32B5/16 ,  B05D7/00

    CPC分类号： A61K47/32 ,  A61K9/167 ,  C08F230/08 ,  C08F257/02 ,  C08F265/00 ,  C08F265/04 ,  C08F289/00 ,  C08F291/00 ,  C08F292/00 ,  C08F2220/287 ,  C08F2220/306 ,  C08L51/003 ,  C08L51/10 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998 ,  C08L2666/02

    摘要： The object of the present invention is to provide a particle for medical use which has an excellent capability of fixing a biologically active substance and such a chemical/physical stability that the particle is less dissolved or deteriorated in a washing step, and a particle for analysis which has an excellent capability of capturing a biomolecule and such a chemical/physical stability that the particle is less dissolved or deteriorated in a washing step.The object of the present invention is achieved by a particle for medical use which has on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing a polymerizable monomer having a functional group for fixing a biologically active substance, and causing the mixture to develop polymerization reaction The object of the present invention is also achieved by a particle for analysis of the interaction of biomolecules, which particle having on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing a polymerizable monomer having a functional group for fixing a biologically active substance, and causing the mixture to develop, polymerization reaction, wherein the biologically active substance is fixed through the functional group for fixing a biologically active substance in the polymer-containing layer.

    摘要翻译： 本发明的目的是提供一种医疗用颗粒，其具有优异的固定生物活性物质的能力和在洗涤步骤中颗粒较少溶解或劣化的化学/物理稳定性和用于分析的颗粒 其具有捕获生物分子的优异能力和在洗涤步骤中颗粒较少溶解或劣化的化学/物理稳定性。 本发明的目的是通过一种用于医疗用途的颗粒来实现的，其表面上具有通过将可聚合官能团或链转移基团引入核心颗粒的表面而形成的含聚合物层，将所得颗粒 具有可聚合单体，其含有具有用于固定生物活性物质的官能团的可聚合单体，并使混合物产生聚合反应本发明的目的还通过用于分析生物分子的相互作用的颗粒来实现，该颗粒具有 在其表面上形成通过将可聚合官能团或链转移基团引入核心颗粒的表面而形成的含聚合物层，将所得颗粒与可聚合单元混合，所述可聚合组分含有用于固定生物学的官能团的可聚合单体 活性物质，并使混合物发生聚合 反应，其中通过用于将生物活性物质固定在含聚合物的层中的官能团固定生物活性物质。