公开(公告)号：US20040253184A1

公开(公告)日：2004-12-16

申请号：US10445732

申请日：2003-05-27

申请人： Targesome, Inc.

发明人： King Chuen Li ,  Mark David Bednarski ,  Richard Wood Storrs ,  Henry Y. Li ,  Francois Daniel Tropper ,  Curtis Kang Hoon Song ,  Dorothy Anna Sipkins ,  Jeremy Kenji Kuniyoshi

IPC分类号： A61K049/00 ,  A61K009/127

CPC分类号： G01N33/586 ,  A61K49/1812 ,  A61K49/22 ,  A61K51/1237 ,  Y10S424/812 ,  Y10S436/829 ,  Y10S977/775 ,  Y10S977/795 ,  Y10S977/808 ,  Y10S977/897 ,  Y10S977/907 ,  Y10S977/918 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/93

摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.

摘要翻译： 聚合的脂质体颗粒与靶向剂连接并且还可与造影增强剂连接和/或连接或包封处理剂。 靶向成像增强聚合的脂质体颗粒与保持图像增强剂的生物靶标与特定位点相互作用，通过磁共振，放射性，x射线或光学成像在疾病期间细胞和组织中分子的表达提供体外和体内研究，以及 病理。 靶向聚合的脂质体可以连接或包封处理剂，例如蛋白质，药物或激素，用于定向递送到特定生物位点用于治疗。