Method and system for digital biomarkers platform

    公开(公告)号:US12237086B2

    公开(公告)日:2025-02-25

    申请号:US17653248

    申请日:2022-03-02

    Abstract: Non-communicable diseases (NCDs) are the pandemics of modern era and are generating huge impact in the modern society. Conventional methods are inaccurate due to a challenge in handling data from heterogenous sensors. The present disclosure is capable of tracking fitness parameters of a user even with heterogenous sensors. Initially, the system receives a raw data from a plurality of heterogenous sensors associated with the user. The raw data is further transformed into a metadata format associated with the corresponding sensor. The transformed data is temporally aligned based on a time based slotting. An algorithm pipeline corresponding to a disorder to be analyzed is selected from a Directed Acyclic Graph (DAG) based on a sensor metadata and a plurality of algorithm metadata corresponding to a plurality of algorithms stored in an algorithm database and an algorithm pipeline. The corresponding disorder is analyzed using the algorithm pipeline.

    Systems and methods for atrial fibrillation (AF) and cardiac disorders detection from biological signals

    公开(公告)号:US12220262B2

    公开(公告)日:2025-02-11

    申请号:US17203578

    申请日:2021-03-16

    Abstract: Continuous monitoring of subject's cardiac system using biological signal(s) (BS) during day-to-day activities is essential for managing personal cardiac health/disorders, etc. Conventional systems/methods lack in improvising overall classification results and configured for specific device/signal say ECG or PPG and so on. Present disclosure provides systems and methods for classifying BS obtained from users, wherein BS are preprocessed to obtain filtered signals (FS). Corresponding feature extraction module is utilized for feature set extraction based on features in FS. The feature set is reduced and segmented into test and training data. Biological signal classification model(s) are generated using training data and a BCM is applied on test data to classify biological signals (BS) as one of Atrial Fibrillation (AF), a non-AF, a cardiac arrythmia disorder, or ischemia. Accelerometer features of connected device associated with the users can be obtained to detect activities which in conjunction with the BCM's output improvises above classification.

    Neuromodulation based adaptive controller for mitral stenosis

    公开(公告)号:US11728040B2

    公开(公告)日:2023-08-15

    申请号:US17149059

    申请日:2021-01-14

    Abstract: This disclosure provides a simulation platform to study and perform predictive analysis on valvular heart disease, Mitral stenosis (MS) and provides a control approach to correct hemodynamic imbalances during MS conditions. Conventional approaches of valve repair or replacement are often associated with risk of thromboembolism, need for anticoagulation, prosthetic endocarditis, and impaired left ventricle function. The cardiovascular hemodynamics model of the present disclosure helps to create ‘what if’ conditions to study variations in different hemodynamic parameters like blood flow, aortic and ventricular pressure, etc. during normal and pathological conditions. An adaptive control system in conjunction with the hemodynamic cardiovascular system (CVS) is provided to handle hemodynamic disbalance during moderate to severe MS conditions. The adaptive controller is hypothesized in line with the neuromodulation approach and modulates left ventricular contractility and vagal tone to counter the symptoms associated with MS.

    Recurrent neural network architecture based classification of atrial fibrillation using single lead ECG

    公开(公告)号:US11571162B2

    公开(公告)日:2023-02-07

    申请号:US16827812

    申请日:2020-03-24

    Abstract: Conventionally, Atrial Fibrillation (AF) has been detected using atrial analyses which is vulnerable to background noise. Again there is a dependency on statistical features which are extracted from R-R intervals of long ECG recordings. The present disclosure addresses AF detection from single lead short ECG recordings of less than one minute wherein automatic detection of P-R and P-Q intervals is difficult, which introduces error in feature computing from the segregated intervals and compromises the performance of the classifier. In the present disclosure, a Recurrent Neural Network (RNN) based architecture comprising two Long Short Term Memory (LSTM) networks is provided for temporal analysis of R-R intervals and P wave regions in an ECG signal respectively. Output sates of the two LSTM networks are merged at a dense layer along with a set of hand-crafted statistical features to create a composite feature set for classification of the AF.

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