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公开(公告)号：US20100285112A1
公开(公告)日：2010-11-11
申请号：US12774330
申请日：2010-05-05
申请人： Tatiana Novobrantseva , Akin Akinc , Tsukasa Sugo
发明人： Tatiana Novobrantseva , Akin Akinc , Tsukasa Sugo
IPC分类号： A61K9/127 , C12N5/078 , A61K31/713 , A61K9/14 , A61K31/7105 , C12N5/0781 , C12N5/0783 , C12N5/0786 , C12N5/0787 , A61P37/02
CPC分类号： A61K31/713 , A61K9/127 , A61K9/1277 , A61K47/6911
摘要： The invention relates to the field of delivery of nucleic acid-based agents to immune cells.
摘要翻译： 本发明涉及基于核酸的试剂递送到免疫细胞的领域。
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公开(公告)号：US08664193B2
公开(公告)日：2014-03-04
申请号：US13619657
申请日：2012-09-14
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
摘要翻译： 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US20110097720A1
公开(公告)日：2011-04-28
申请号：US12811503
申请日：2008-12-31
申请人： Marco A. Ciufolini , Thomas D. Madden , Michael J. Hope , Barbara Mui , De Fougerolles Antonin , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy , Pieter Rutter Cullis
发明人： Marco A. Ciufolini , Thomas D. Madden , Michael J. Hope , Barbara Mui , De Fougerolles Antonin , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy , Pieter Rutter Cullis
CPC分类号： G01N33/5088 , A01K2207/05 , A01K2227/105 , A01K2267/0381 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Y304/21021 , G01N33/5023 , G01N33/5067 , G01N33/86 , G01N2333/745 , G01N2333/96447
摘要： The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
摘要翻译： 本发明的特征在于通过筛选试剂对模型受试者的肝脏的影响来鉴定治疗相关组合物的方法，所述组合物包括治疗剂和2,2-二苯胺基-4-二甲基氨基甲基 - [1,3] - 二氧杂环戊烷。
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公开(公告)号：US20130184326A1
公开(公告)日：2013-07-18
申请号：US13619657
申请日：2012-09-14
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
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公开(公告)号：US08334273B2
公开(公告)日：2012-12-18
申请号：US12970673
申请日：2010-12-16
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
摘要翻译： 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US20110045473A1
公开(公告)日：2011-02-24
申请号：US12811511
申请日：2008-12-31
CPC分类号： G01N33/86 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12Y304/21021 , G01N2333/96447 , Y10T436/143333
摘要： The invention features a method of identifying therapeutically relevant compositions that include a therapeutic agent and a delivery component by screening for an effect of the agent on the liver of a model subject.
摘要翻译： 本发明的特征在于通过筛选试剂对模型受试者的肝脏的影响来鉴定包括治疗剂和递送组分的治疗相关组合物的方法。
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公开(公告)号：US07871985B2
公开(公告)日：2011-01-18
申请号：US12331708
申请日：2008-12-10
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
摘要翻译： 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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8.发明申请LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES 审中-公开脂质体制剂组合物和抑制Eg5和VEGF基因表达的方法公开(公告)号：US20100267806A1
公开(公告)日：2010-10-21
申请号：US12723471
申请日：2010-03-12
IPC分类号： A61K31/713 , A61P35/00 , C12N5/02
CPC分类号： C12N15/1136 , A61K31/44 , A61K31/713 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , C12N2799/04
摘要： This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a lipid formulation, and methods of using the compositions to inhibit the expression of the Human kinesin family member 11 (Eg5) and Vascular Endothelial Growth Factor (VEGF), and methods of using the compositions to treat pathological processes mediated by Eg5 and VEGF expression, such as cancer.
摘要翻译： 本发明涉及在脂质制剂中含有双链核糖核酸（dsRNA）的组合物，以及使用该组合物抑制人驱动蛋白家族成员11（Eg5）和血管内皮生长因子（VEGF）的表达的方法，以及方法 使用组合物来治疗由Eg5和VEGF表达介导的病理过程，例如癌症。
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公开(公告)号：US20120225434A1
公开(公告)日：2012-09-06
申请号：US13460963
申请日：2012-05-01
申请人： Marco A. CIUFOLINI , Thomas D. Madden , Michael J. Hope , Barbara Mui , Antonin de Fougerolles , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy , Pieter Rutter Cullis
发明人： Marco A. CIUFOLINI , Thomas D. Madden , Michael J. Hope , Barbara Mui , Antonin de Fougerolles , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy , Pieter Rutter Cullis
CPC分类号： G01N33/5088 , A01K2207/05 , A01K2227/105 , A01K2267/0381 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Y304/21021 , G01N33/5023 , G01N33/5067 , G01N33/86 , G01N2333/745 , G01N2333/96447
摘要： The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
摘要翻译： 本发明的特征在于通过筛选试剂对模型受试者的肝脏的影响来鉴定治疗相关组合物的方法，所述组合物包括治疗剂和2,2-二苯胺基-4-二甲基氨基甲基 - [1,3] - 二氧杂环戊烷。
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公开(公告)号：US08912316B2
公开(公告)日：2014-12-16
申请号：US13612521
申请日：2012-09-12
申请人： Antonin De Fougerolles , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Sina Bavari , Kelly Lyn Warfield
发明人： Antonin De Fougerolles , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Sina Bavari , Kelly Lyn Warfield
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/113 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
摘要翻译： 本发明涉及用于抑制CD45基因表达的双链核糖核酸（dsRNA）。
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