-
公开(公告)号：US20110097720A1
公开(公告)日：2011-04-28
申请号：US12811503
申请日：2008-12-31
申请人： Marco A. Ciufolini , Thomas D. Madden , Michael J. Hope , Barbara Mui , De Fougerolles Antonin , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy , Pieter Rutter Cullis
发明人： Marco A. Ciufolini , Thomas D. Madden , Michael J. Hope , Barbara Mui , De Fougerolles Antonin , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy , Pieter Rutter Cullis
CPC分类号： G01N33/5088 , A01K2207/05 , A01K2227/105 , A01K2267/0381 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Y304/21021 , G01N33/5023 , G01N33/5067 , G01N33/86 , G01N2333/745 , G01N2333/96447
摘要： The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
摘要翻译： 本发明的特征在于通过筛选试剂对模型受试者的肝脏的影响来鉴定治疗相关组合物的方法，所述组合物包括治疗剂和2,2-二苯胺基-4-二甲基氨基甲基 - [1,3] - 二氧杂环戊烷。
-
公开(公告)号：US20110117125A1
公开(公告)日：2011-05-19
申请号：US12811195
申请日：2008-12-31
申请人： Michael J. Hope , Sean C. Semple , Jianxin Chen , Thomas D. Madden , Barbara Mui , Pieter R. Cullis , Marco A. Ciufolini , Kim F. Wong , Muthiah Manoharan , Rajeev G. Kallanthottathil
发明人： Michael J. Hope , Sean C. Semple , Jianxin Chen , Thomas D. Madden , Barbara Mui , Pieter R. Cullis , Marco A. Ciufolini , Kim F. Wong , Muthiah Manoharan , Rajeev G. Kallanthottathil
IPC分类号： A61K39/12 , A61K39/00 , A61K39/02 , C12N5/02 , A61K31/7088 , A61P37/00 , C07D295/12 , C07D241/04 , C07D317/00 , C11C3/00 , C07C229/00 , C07C229/30 , C07C321/00
CPC分类号： A61K31/7088 , A61K9/127 , A61K9/1275 , C07C215/10 , C07C217/08 , C07C217/28 , C07C219/08 , C07C229/12 , C07C271/12 , C07C323/25 , C07D317/28
摘要： The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译： 本发明提供了将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型脂质和核酸 - 脂质颗粒，并将包封的核酸有效地递送到细胞体内。 本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。
-
公开(公告)号：US20110256175A1
公开(公告)日：2011-10-20
申请号：US13123307
申请日：2009-10-09
申请人： Michael J. Hope , Sean C. Semple , Jianxin Chen , Thomas D. Madden , Pieter R. Cullis , Marco A. Ciufolini , Barbara Low Shoud Mui
发明人： Michael J. Hope , Sean C. Semple , Jianxin Chen , Thomas D. Madden , Pieter R. Cullis , Marco A. Ciufolini , Barbara Low Shoud Mui
IPC分类号： A61K39/12 , C07D319/06 , C07D405/06 , C07D413/06 , A61K47/44 , A61K31/7088 , A61K48/00 , A61K31/713 , C12N5/071 , C12N15/63 , A61K39/02 , A61K39/00 , A61P37/04 , A61P35/00 , A61P31/12 , A61P31/04 , A61P33/00 , C07D317/28
CPC分类号： A61K47/22 , A61K9/1271 , A61K31/713 , A61K39/39 , A61K2039/55511 , C07D317/28 , C07D319/06
摘要： The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译： 本发明提供优异的用于将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型脂质和核酸 - 脂质颗粒，并将包封的核酸有效地递送到细胞体内。 本发明的组合物是高度有效的，从而允许在相对低的剂量下有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。
-
公开(公告)号：US09139554B2
公开(公告)日：2015-09-22
申请号：US13123307
申请日：2009-10-09
申请人： Michael J. Hope , Sean C. Semple , Jianxin Chen , Thomas D. Madden , Pieter R. Cullis , Marco A. Ciufolini , Barbara Low Shoud Mui
发明人： Michael J. Hope , Sean C. Semple , Jianxin Chen , Thomas D. Madden , Pieter R. Cullis , Marco A. Ciufolini , Barbara Low Shoud Mui
IPC分类号： C07D317/28 , A61K9/127 , C07D319/06
CPC分类号： A61K47/22 , A61K9/1271 , A61K31/713 , A61K39/39 , A61K2039/55511 , C07D317/28 , C07D319/06
摘要： The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译： 本发明提供优异的用于将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型脂质和核酸 - 脂质颗粒，并将包封的核酸有效地递送到细胞体内。 本发明的组合物是高度有效的，从而允许在相对低的剂量下有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。
-
公开(公告)号：US20120058144A1
公开(公告)日：2012-03-08
申请号：US13128363
申请日：2009-11-10
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Marco A. Ciufolini
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Marco A. Ciufolini
IPC分类号： A61K39/00 , C07D211/46 , C07D207/12 , C07D317/28 , C07C217/52 , C07C291/04 , A61K47/18 , A61K47/28 , A61K47/22 , A61K48/00 , A61K31/713 , C12N5/00 , A61K39/12 , A61K39/02 , A61P31/12 , A61P31/04 , A61P33/00 , A61P35/00 , A61P37/04 , C07C229/46
CPC分类号： A61K31/7088 , A61K9/1272 , A61K31/7105 , A61K39/00 , A61K2039/55561 , A61K2039/6018 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2320/32 , C12N2310/3521 , C12N2310/3533
摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures XIV or XVII.
摘要翻译： 本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。 特别地，本发明提供具有以下结构XIV或XVII的脂质。
-
6.发明申请2-(3-AMINOARYL) AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS 有权2-（3-氨基）氨基-4-芳基噻唑及其作为C-CIT抑制剂的用途公开(公告)号：US20120053186A1
公开(公告)日：2012-03-01
申请号：US13015664
申请日：2011-01-28
IPC分类号： A61K31/496 , A61P29/00 , A61P19/08 , A61P35/00 , A61P1/00 , A61P31/00 , A61P3/00 , A61P25/28 , A61P3/10 , A61P31/12 , A61P31/04 , A61P37/08 , A61P11/06 , A61P17/00 , A61P33/00 , A61P21/00 , A61P17/06 , A61P41/00 , A61P3/04 , A61P3/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/24 , A61P15/00 , A61P25/22 , A61P25/08 , A61P25/18 , A61P25/16 , A61P25/30 , A61P35/02 , A61P37/00
CPC分类号： C07D417/04 , C07D277/42 , C07D277/56 , C07D417/14
摘要： Novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors.
摘要翻译： 选自式（I）的2-（3-氨基芳基）氨基-4-芳基 - 噻唑的新型化合物，其选择性调节，调节和/或抑制由某种天然和/或突变体酪氨酸激酶介导的信号转导， 人类和动物疾病如细胞增殖代谢，过敏性和退行性疾病。 更具体地说，这些化合物是有效和选择性的c-kit抑制剂。
-
7.发明申请COMPOSITIONS AND METHODS FOR ENHANCING CELLULAR UPTAKE AND INTRACELLULAR DELIVERY OF LIPID PARTICLES 审中-公开用于增强细胞摄取和脂质细胞的细胞内递送的组合物和方法公开(公告)号：US20120264810A1
公开(公告)日：2012-10-18
申请号：US13497395
申请日：2010-09-22
申请人： Paulo J.C. Lin , Yuen Yi c. Tam , Srinivasulu Masuna , Marco A. Ciufolini , Michel Roberge , Pieter R. Cullis
发明人： Paulo J.C. Lin , Yuen Yi c. Tam , Srinivasulu Masuna , Marco A. Ciufolini , Michel Roberge , Pieter R. Cullis
IPC分类号： C07J41/00 , A61K47/24 , C12N5/071 , A61K31/713 , A61K47/22 , C07D215/46 , A61K31/7105
CPC分类号： C07J51/00 , A61K9/1271 , C12N15/88
摘要： Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that binds a Na+/K+ ATPase to enhance uptake of the lipid particle b\ the cell Related compositions useful in practicing methods include lipid particles comprising a conjugated compound that enhances uptake of the lipid particles b\ the cell The methods and compositions are useful in delivering a therapeutic agent to a cell, e g for the treatment of a disease or disorder in a subject
摘要翻译： 在具体实施方案中，本发明的方法包括使细胞与脂质颗粒和结合Na + / K + ATP酶的化合物接触以增强吸收，所述组合物，方法和化合物可用于增强脂质颗粒摄取 脂质颗粒b \细胞相关组合物可用于实践方法包括脂质颗粒，其包含增强脂质颗粒摄取的共轭化合物。该方法和组合物可用于将治疗剂递送至细胞，例如用于 治疗受试者的疾病或病症
-
8.发明申请BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM 有权抑郁症的多巴胺抑制剂及其用于治疗与异常脂肪代谢相关的肥胖，过度和/或疾病的用途公开(公告)号：US20140187479A1
公开(公告)日：2014-07-03
申请号：US14107855
申请日：2013-12-16
申请人： Itzik Harosh , Sandrine Braud , Marco A. Ciufolini
发明人： Itzik Harosh , Sandrine Braud , Marco A. Ciufolini
CPC分类号： C07K5/08 , A61K38/00 , A61K38/005 , A61K38/05 , A61K38/06 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06191 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0827
摘要： Novel compounds, particularly derivatives of boroarginine, boroornithine and borolysine that selectively modulate, regulate, and/or inhibit enteropeptidase. Compositions, particularly pharmaceutical compositions, as well as methods to treat excess weight, obesity and diseases associated with an abnormal fat metabolism.
摘要翻译： 选择性调节，调控和/或抑制肠肽酶的新型化合物，特别是硼精氨酸衍生物，硼代鸟氨酸和硼氢化钠。 组合物，特别是药物组合物，以及治疗过量体重，肥胖和与异常脂肪代谢相关的疾病的方法。
-
公开(公告)号：US08722082B2
公开(公告)日：2014-05-13
申请号：US13128363
申请日：2009-11-10
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Marco A. Ciufolini
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Marco A. Ciufolini
CPC分类号： A61K31/7088 , A61K9/1272 , A61K31/7105 , A61K39/00 , A61K2039/55561 , A61K2039/6018 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2320/32 , C12N2310/3521 , C12N2310/3533
摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures XIV or XVII.
摘要翻译： 本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。 特别地，本发明提供具有以下结构XIV或XVII的脂质。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.042 秒)
