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    Thermally stabilized butadiene resins containing a hindered phenolic acrylate or methacrylate
    7.
    发明授权
    Thermally stabilized butadiene resins containing a hindered phenolic acrylate or methacrylate 失效
    含有受阻酚丙烯酸酯或甲基丙烯酸酯的热稳定丁二烯树脂

    公开(公告)号：US4774274A

    公开(公告)日：1988-09-27

    申请号：US64461

    申请日：1987-06-22

    申请人： Takeshi Takata ,  Shin-ichi Yachigo ,  Tatsuo Kaneoya ,  Haruki Okamura ,  Yukoh Takahashi

    发明人： Takeshi Takata ,  Shin-ichi Yachigo ,  Tatsuo Kaneoya ,  Haruki Okamura ,  Yukoh Takahashi

    IPC分类号： C08K5/134 ,  C08K5/10

    CPC分类号： C08K5/134

    摘要： A process for producing a bisphenol compound useful as deterioration preventor capable of stabilizing organic substances against the decompositions caused by heat, light and oxygen, represented by the following general formula: ##STR1## wherein R.sub.1 represents alkyl group having 1 to 3 carbon atoms, alkenyl group having 2 to 4 carbon atoms, phenyl group or 2-phenylethenyl group; R.sub.2 represents alkyl group having 1 to 5 carbon atoms, or cyclohexyl group; R.sub.3 represents alkyl group having 1 to 9 carbon atoms, cyclohexyl group or phenyl group; and R.sub.4 represents alkyl group having 1 to 11 carbon atoms or phenyl group, which comprises reacting a carboxylic acid represented by the following general formula: ##STR2## wherein R.sub.1 is as defined above, with a bisphenol compound represented by the following general formula: ##STR3## wherein R.sub.2, R.sub.3 and R.sub.4 are as defined above, by the use of a halogenating agent in the presence of a dehydrohalogenating agent, as well as butadiene polymer compositions containing said bisphenol compounds.

    摘要翻译： 一种生产双酚化合物的方法，该双酚化合物可用作能够稳定有机物质以抵抗由热，光和氧引起的分解引起的降解防止剂，由以下通式表示：其中R 1表示具有1至3个碳原子的烷基，烯基 具有2至4个碳原子的基团，苯基或2-苯基乙烯基; R2表示具有1至5个碳原子的烷基或环己基; R3表示具有1至9个碳原子的烷基，环己基或苯基; R 4表示具有1〜11个碳原子的烷基或苯基，其包括使由以下通式表示的羧酸与下述通式表示的双酚化合物反应：其中R 1如上定义。 其中R2，R3和R4如上定义，在脱卤化氢剂存在下使用卤化剂，以及含有所述双酚化合物的丁二烯聚合物组合物。

    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof
    8.
    发明授权
    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof 有权
    Vγ9Vδ2T细胞增殖剂，活化的Vγ9Vδ2T细胞的制造方法及其用途

    公开(公告)号：US07749760B2

    公开(公告)日：2010-07-06

    申请号：US12316973

    申请日：2008-12-17

    申请人： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    发明人： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    IPC分类号： C12N5/078 ,  C12N5/0783 ,  C07K14/54 ,  C07F9/40

    CPC分类号： A61K31/663 ,  A61K38/20 ,  A61K38/2013 ,  C12N5/0638 ,  C12N2501/2302 ,  C12N2501/2318 ,  C12N2501/999 ,  Y02A50/411 ,  A61K2300/00

    摘要： A Vγ9Vδ2 T cell proliferation agent includes at least a bisphosphonate, interleukin 2, and interleukin 18. Since IL-18 has properties that improve cell viability by inhibiting cell death, IL-18 is presumably capable of acting as a cofactor for the bisphosphonate so as to significantly increase the effect of Vγ9Vδ2 T cell proliferation by the bisphosphonate and the IL-2. This allows providing a Vγ9Vδ2 T cell proliferation agent capable of growing Vγ9Vδ2 T cells with a proliferated efficiency significantly high compared to conventional methods so that the proliferated Vγ9Vδ2 T cells have a high antitumor activity and high cytokine productivity.

    摘要翻译： Vγ9Vδ2T细胞增殖剂包括至少二膦酸盐，白细胞介素2和白细胞介素18.由于IL-18具有通过抑制细胞死亡来改善细胞活力的性质，因此推测IL-18能够作为双膦酸盐的辅因子，以便 显着增加了双膦酸盐和IL-2对Vγ9Vδ2T细胞增殖的影响。 这允许提供与常规方法相比，能够以增殖效率显着增加Vγ9Vδ2T细胞的Vγ9Vδ2T细胞增殖剂，使得增殖的Vγ9Vδ2T细胞具有高抗肿瘤活性和高细胞因子生产力。

    Purification of hydroxyphenylpropionic acid ester
    9.
    发明授权
    Purification of hydroxyphenylpropionic acid ester 失效
    羟基苯丙酸酯的纯化

    公开(公告)号：US4739080A

    公开(公告)日：1988-04-19

    申请号：US868742

    申请日：1986-05-30

    申请人： Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    发明人： Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    IPC分类号： C07D493/10 ,  C08K5/1575 ,  C07D319/04

    CPC分类号： C07D493/10

    摘要： Method for the purification of 3,9-bis{2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionyloxy]-1,1-dimethylethyl} -2,4,8,10-tetraoxaspiro[5.5]undecane, to form crystals having a crystalline structure which, when subjected to Cu-K.sub..alpha. X-ray diffraction, show sharp X-ray diffraction peaks at angles of diffraction, to 2.theta.=2.8.degree., 2.theta.=8.7.degree. and 2.theta.=11.7.degree., by recrystallizing the ester at a temperature lower than 40.degree. C. using as a recrystallization solvent, A C.sub.5 -C.sub.10 alicyclic hydrocarbon, which may contain a limited amount of certain other solvents, or using a mixed solvent of a C.sub.5 -C.sub.10 aliphatic hydrocarbon and at least one other certain solvent in a certain weight ratio.

    摘要翻译： 纯化3,9-双{2- [3-（3-叔丁基-4-羟基-5-甲基苯基）丙酰氧基] -1,1-二甲基乙基} -2,4,8,10-四氧杂螺环 [5.5]十一烷，以形成具有晶体结构的晶体，当经受Cu-Kαα射线衍射时，衍射角呈现尖锐的X射线衍射峰，为2θ= 2.8°，2θ= 8.7° 和2θ= 11.7°，通过在低于40℃的温度下使酯重结晶，使用可能含有有限量的某些其它溶剂的A C5-C10脂环族烃，或使用混合溶剂 一种C 5 -C 10脂族烃和至少一种其它特定溶剂。