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公开(公告)号：US20120225055A1
公开(公告)日：2012-09-06
申请号：US13037505
申请日：2011-03-01
申请人： Tejinder Kaur BHINDER , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Mark Brian Pepys
发明人： Tejinder Kaur BHINDER , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Mark Brian Pepys
IPC分类号： A61K39/395 , C07H21/00 , C12N15/63 , C12N1/00 , A61P25/00 , C12P21/02 , C07D403/06 , A61P25/28 , A61P43/00 , A61P3/10 , C07K16/18 , C12N5/10
CPC分类号： C07K16/18 , A61K31/4025 , A61K39/3955 , A61K2039/505 , C07D403/06 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/92
摘要： The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.
摘要翻译： 本发明涉及结合血清淀粉样蛋白P组分（SAP）的抗体结合蛋白（例如抗体），编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物和制备方法。 本发明还涉及这种抗原结合蛋白在治疗或预防与淀粉样蛋白沉积相关的疾病中的应用，包括全身性淀粉样变性病，局部淀粉样变性病，阿尔茨海默病和2型糖尿病。
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公开(公告)号：US09434716B2
公开(公告)日：2016-09-06
申请号：US13037505
申请日：2011-03-01
申请人： Tejinder Kaur Bhinder , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Mark Brian Pepys
发明人： Tejinder Kaur Bhinder , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Mark Brian Pepys
IPC分类号： C07K16/00 , C07D403/06 , C07K16/18 , A61K39/00
CPC分类号： C07K16/18 , A61K31/4025 , A61K39/3955 , A61K2039/505 , C07D403/06 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/92
摘要： The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.
摘要翻译： 本发明涉及结合血清淀粉样蛋白P组分（SAP）的抗体结合蛋白（例如抗体），编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物和制备方法。 本发明还涉及这种抗原结合蛋白在治疗或预防与淀粉样蛋白沉积相关的疾病中的应用，包括全身性淀粉样变性病，局部淀粉样变性病，阿尔茨海默病和2型糖尿病。
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公开(公告)号：US08921523B2
公开(公告)日：2014-12-30
申请号：US12330541
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： C07K16/46 , C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with the antigen binding proteins; pharmaceutical compositions comprising the antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，与抗原结合蛋白; 包含抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US20110014182A1
公开(公告)日：2011-01-20
申请号：US12746837
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61P25/28 , A61K38/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US20090162358A1
公开(公告)日：2009-06-25
申请号：US12330541
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： A61K39/395 , C07K14/47 , C07K16/18 , A61P25/28 , A61P27/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人β-淀粉样蛋白肽的抗原结合蛋白; 治疗以β-淀粉样蛋白水平升高或β-淀粉样蛋白沉积为特征的疾病或病症的方法，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于β-淀粉样蛋白水平升高或β-淀粉样蛋白沉积，包括年龄相关性黄斑变性 和青光眼型疾病和β-淀粉样蛋白依赖性白内障形成，具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US20110064740A1
公开(公告)日：2011-03-17
申请号：US12679917
申请日：2008-09-23
申请人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： A61K39/395 , C07K16/00 , A61P27/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要： The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译： 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成， 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白，特别是人和淀粉样蛋白肽。
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公开(公告)号：US08858943B2
公开(公告)日：2014-10-14
申请号：US12679917
申请日：2008-09-23
申请人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号： A61K39/395 , A61K35/30 , A61K35/44 , C07K16/18 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要： The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译： 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成， 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白，特别是人和淀粉样蛋白肽。
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公开(公告)号：US20130302335A1
公开(公告)日：2013-11-14
申请号：US13978228
申请日：2012-01-04
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N1/00 , C12N15/09
摘要： The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.
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公开(公告)号：US20130251724A1
公开(公告)日：2013-09-26
申请号：US13989191
申请日：2011-11-21
申请人： Gary Peter Bembridge , Chun-Wa Chung , Maria Feeney , Susannah Karen Ford , Ian Kirby , Ruth McAdam
发明人： Gary Peter Bembridge , Chun-Wa Chung , Maria Feeney , Susannah Karen Ford , Ian Kirby , Ruth McAdam
IPC分类号： C07K16/24
CPC分类号： C07K16/248 , C07K16/24 , C07K16/244 , C07K2317/10 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns antigen binding proteins and fragments thereof which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. The invention also concerns a method of humanising antibodies. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
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公开(公告)号：US20120177651A1
公开(公告)日：2012-07-12
申请号：US13322207
申请日：2010-05-26
IPC分类号： A61K39/395 , C07K16/18 , C12N1/21 , C12P21/06 , C12N5/10
CPC分类号： C07K16/22 , A61K39/3955 , C07K16/468 , C07K2317/569 , C07K2317/73 , C07K2317/76
摘要： The invention relates to combinations of HGF antagonists with VEGF antagonists, and provides antigen-binding proteins which bind to HGF comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding protein has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及HGF拮抗剂与VEGF拮抗剂的组合，并提供与HGF结合的抗原结合蛋白，其包含与一个或多个表位结合结构域连接的蛋白质支架，其中所述抗原结合蛋白具有至少两个抗原结合位点 其中至少一个来自表位结合结构域，并且其中至少一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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