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公开(公告)号：US10275680B2
公开(公告)日：2019-04-30
申请号：US14352099
申请日：2012-10-18
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Leor Zach , David Guez , David Last , Dianne Daniels , Yael Mardor
Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
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公开(公告)号：US10970594B2
公开(公告)日：2021-04-06
申请号：US16280089
申请日：2019-02-20
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Leor Zach , David Guez , David Last , Dianne Daniels Elmakias , Yael Mardor , Shirley Sharabi , Noam Nissan , Miriam Sklair-Levy
Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
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公开(公告)号：US11931569B2
公开(公告)日：2024-03-19
申请号：US16980104
申请日：2019-03-12
Inventor： Yael Mardor , Shirley Sharabi , Itzik Cooper , David Last , David Guez , Dianne Daniels Elmakias , Yael Bresler
Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.
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Patent Agency Ranking
公开(公告)号：US11892530B2
公开(公告)日：2024-02-06
申请号：US16992163
申请日：2020-08-13
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Yael Mardor , Leor Zach , David Guez , David Last , Dianne Daniels Elmakias
IPC: G01R33/28 , G01R33/56 , G01R33/48 , A61B5/055 , A61B5/00 , G06T7/00 , G16H40/40 , G16H30/40 , G16H40/63 , A61K31/166 , A61K31/7068 , A61K31/555
CPC classification number: G01R33/281 , A61B5/0042 , A61B5/055 , A61B5/4842 , A61B5/4848 , A61B5/7275 , G01R33/4806 , G01R33/5601 , G01R33/5608 , G06T7/0016 , G16H30/40 , G16H40/40 , G16H40/63 , A61B2576/026 , A61K31/166 , A61K31/555 , A61K31/7068 , A61K2300/00 , G06T2207/10096 , G06T2207/30016 , G06T2207/30096
Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
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公开(公告)号：US20140270451A1
公开(公告)日：2014-09-18
申请号：US14352099
申请日：2012-10-18
Inventor： Leor Zach , David Guez , David Last , Dianne Daniels , Yael Mardor
CPC classification number: G06K9/6202 , A61B5/0037 , A61B5/0042 , A61B5/055 , A61B2576/026 , G06T7/0012 , G16H50/50
Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
Abstract translation: 公开了用于分析脑MRI的装置。 该装置包括用于在对比度施加后的预定时间间隔的开始和结束处接收第一和第二次MRI扫描的输入; 一种减法映射表，用于通过分析所述扫描来分析所述扫描以区分两个主要群体，其中来自组织的对比度清除比对比度积累慢的群体，以及快速群体，从而形成来自所述第一和所述第二次MRI扫描的减法映射 这个清除速度比积累快; 以及输出以提供所述两个主要群体的分布的指示，其中所述预定时间段至少为二十分钟。
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公开(公告)号：US11933866B2
公开(公告)日：2024-03-19
申请号：US16992160
申请日：2020-08-13
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Yael Mardor , Leor Zach , David Guez , David Last , Dianne Daniels Elmakias
IPC: G01R33/28 , A61B5/00 , A61B5/055 , G01R33/48 , G01R33/56 , G06T7/00 , G16H30/40 , G16H40/40 , G16H40/63 , A61K31/166 , A61K31/555 , A61K31/7068
CPC classification number: G01R33/281 , A61B5/0042 , A61B5/055 , A61B5/4842 , A61B5/4848 , A61B5/7275 , G01R33/4806 , G01R33/5601 , G01R33/5608 , G06T7/0016 , G16H30/40 , G16H40/40 , G16H40/63 , A61B2576/026 , A61K31/166 , A61K31/555 , A61K31/7068 , A61K2300/00 , G06T2207/10096 , G06T2207/30016 , G06T2207/30096
Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
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公开(公告)号：US10809323B2
公开(公告)日：2020-10-20
申请号：US14787040
申请日：2014-04-24
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Yael Mardor , Leor Zach , David Guez , David Last , Dianne Daniels
IPC: A61B5/055 , A61B5/00 , G01R33/28 , G01R33/56 , G01R33/48 , G06T7/00 , G16H40/40 , G16H30/40 , G16H40/63 , A61K31/166 , A61K31/7068 , A61K31/555
Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
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公开(公告)号：US20170247429A1
公开(公告)日：2017-08-31
申请号：US15505526
申请日：2015-09-16
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Itzik Cooper , David Guez , David Last , Yoram Shechter , Matityahu Fridkin , Yael Mardor
IPC: C07K14/765 , A61K9/00 , A61K45/06
CPC classification number: C07K14/765 , A61K9/0085 , A61K38/385 , A61K45/06 , A61K47/643
Abstract: The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders.
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