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1.发明申请CONJUGATE OF WATER-SOLUBLE HYALURONIC ACID MODIFICATION PRODUCT WITH GLP-A ANALOGUE 审中-公开具有GLP-A类似物的水溶性羟尿酸改性产品的结合公开(公告)号：US20090082266A1
公开(公告)日：2009-03-26
申请号：US11908278
申请日：2006-03-08
申请人： Teruo Nakamura , Tatsuya Kato , Hideyuki Togawa , Kenji Yasugi , Hiroko Konishi , Yasuo Sekimori , Tsuyoshi Shimoboji
发明人： Teruo Nakamura , Tatsuya Kato , Hideyuki Togawa , Kenji Yasugi , Hiroko Konishi , Yasuo Sekimori , Tsuyoshi Shimoboji
CPC分类号： C07K14/605 , A61K47/61 , C08B37/0072
摘要： To provide a GLP-1 analogue long-acting prophylactic or therapeutic agent for diabetes, diabetic complications and/or obesity due to diabetes which provides an extended half-life of a GLP-1 analogue in the blood to prevent frequent administration, and is biodegradable and safe.The present invention provides a conjugate obtained by binding, to a GLP-1 analogue into which a mercapto group is incorporated, water soluble hyaluronic acid modification product obtained by incorporating a substituent via an amide bond to the carboxyl group of glucuronic acid portion of hyaluronic acid as a derivative thereof, using a specific condensing agent in an aprotic polar solvent; and a prophylactic or therapeutic agent having a durable blood glucose lowering effect for diabetes, diabetic complications or obesity.
摘要翻译： 提供GLP-1类似物长效预防或治疗糖尿病，由于糖尿病导致的糖尿病并发症和/或肥胖症，其提供血液中GLP-1类似物的延长半衰期以防止频繁施用，并且是可生物降解的 安全。 本发明提供了通过与其中引入巯基的GLP-1类似物结合获得的缀合物，其通过将酰胺键引入到透明质酸的葡萄糖醛酸部分的羧基而获得的水溶性透明质酸改性产物 作为其衍生物，在非质子极性溶剂中使用特定的缩合剂; 以及对糖尿病，糖尿病并发症或肥胖具有持久的血糖降低作用的预防或治疗剂。
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2.发明申请AGGREGABLE GLP-1 ANALOGUE AND SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION 审中-公开可累积的GLP-1类似物和持续释放的药物组合物公开(公告)号：US20090286724A1
公开(公告)日：2009-11-19
申请号：US12067067
申请日：2006-10-26
IPC分类号： A61K38/26 , C07K14/605 , A61P3/10 , A61P3/04
CPC分类号： C07K14/605 , A61K38/00 , Y02A50/473
摘要： The present invention provides a GLP-1 analogue having a high association-aggregability or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition to be used for preventing or treating diabetes, hyperglycemia, a diabetic complication caused by diabetes or hyperglycemia, or obesity, using the same.
摘要翻译： 本发明提供具有高缔合聚集性的GLP-1类似物或其药学上可接受的盐，以及用于预防或治疗糖尿病，高血糖症，由糖尿病或高血糖引起的糖尿病并发症或肥胖的药物组合物，其使用 一样。
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公开(公告)号：US07776329B2
公开(公告)日：2010-08-17
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
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公开(公告)号：US20070190599A1
公开(公告)日：2007-08-16
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US07919086B2
公开(公告)日：2011-04-05
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US07682608B2
公开(公告)日：2010-03-23
申请号：US10488050
申请日：2002-08-29
申请人： Tadao Yamazaki , Hiroko Konishi
发明人： Tadao Yamazaki , Hiroko Konishi
IPC分类号： A61K39/395
CPC分类号： A61K39/39591 , A61K47/183 , C07K16/2896
摘要： A stabilized antibody-containing preparation containing acetyltryptophan or an acetyltryptophan derivative or a salt thereof as a stabilizer for controlling the decrease in the biological activity of the antibody.
摘要翻译： 一种含有乙酰色氨酸或乙酰色氨酸衍生物或其盐作为稳定剂的稳定化抗体制剂，用于控制抗体的生物活性降低。
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公开(公告)号：US20100248359A1
公开(公告)日：2010-09-30
申请号：US12797349
申请日：2010-06-09
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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