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公开(公告)号：US07776329B2
公开(公告)日：2010-08-17
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
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公开(公告)号：US07919086B2
公开(公告)日：2011-04-05
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US20070190599A1
公开(公告)日：2007-08-16
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US20100248359A1
公开(公告)日：2010-09-30
申请号：US12797349
申请日：2010-06-09
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US20110033452A1
公开(公告)日：2011-02-10
申请号：US12852950
申请日：2010-08-09
申请人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
发明人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08 , C12N5/071 , A61P35/00
CPC分类号： C07K16/303 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/732
摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.
摘要翻译： 提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞 岩藻糖转运蛋白 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。
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公开(公告)号：US20080124330A1
公开(公告)日：2008-05-29
申请号：US11577944
申请日：2005-10-26
申请人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
发明人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00 , C12P21/04
CPC分类号： C07K16/303 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/732
摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.
摘要翻译： 提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞 岩藻糖转运蛋白 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。
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公开(公告)号：US07867734B2
公开(公告)日：2011-01-11
申请号：US11577944
申请日：2005-10-26
申请人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
发明人： Kiyotaka Nakano , Izumi Sugo , Masamichi Sugimoto , Takahiro Ishiguro , Megumi Tanaka , Shigeyuki Iijima
CPC分类号： C07K16/303 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/732
摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.
摘要翻译： 提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞 岩藻糖转运蛋白 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。
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公开(公告)号：US08497355B2
公开(公告)日：2013-07-30
申请号：US12733933
申请日：2008-09-26
申请人： Tomoyuki Igawa , Taichi Kuramochi , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana , Takahiro Ishiguro
发明人： Tomoyuki Igawa , Taichi Kuramochi , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana , Takahiro Ishiguro
IPC分类号： C07K16/30 , A61K39/395 , C07H21/04 , C12P21/08 , C12N15/13
CPC分类号： C07K16/2863 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K16/30 , C07K16/303 , C07K2317/14 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N15/8258
摘要： A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient.
摘要翻译： 调节抗磷脂酰肌醇蛋白聚糖3抗体的血浆半衰期的方法，一种药物组合物，其包含具有调节的血浆半衰期的抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分，制备抗磷脂酰肌醇蛋白聚糖的方法 提供了包含抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分的药物组合物。 公开了通过改变暴露于抗磷脂酰肌醇蛋白聚糖3抗体表面的氨基酸残基来调节抗磷脂酰肌醇蛋白聚糖3抗体的血浆半衰期的方法; 和具有通过氨基酸残基修饰调节的血浆半衰期的抗磷脂酰肌醇蛋白聚糖3抗体，包含作为活性成分的磷脂酰肌醇蛋白聚糖3抗体的药物组合物，以及制备抗磷脂酰肌醇蛋白聚糖3抗体的方法和 制备包含抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分的药物组合物。
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公开(公告)号：US20100239577A1
公开(公告)日：2010-09-23
申请号：US12733933
申请日：2008-09-26
申请人： Tomoyuki Igawa , Taichi Kuramochi , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana , Takahiro Ishiguro
发明人： Tomoyuki Igawa , Taichi Kuramochi , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana , Takahiro Ishiguro
CPC分类号： C07K16/2863 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K16/30 , C07K16/303 , C07K2317/14 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N15/8258
摘要： A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient.
摘要翻译： 调节抗磷脂酰肌醇蛋白聚糖3抗体的血浆半衰期的方法，一种药物组合物，其包含具有调节的血浆半衰期的抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分，制备抗磷脂酰肌醇蛋白聚糖的方法 提供了包含抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分的药物组合物。 公开了通过改变暴露于抗磷脂酰肌醇蛋白聚糖3抗体表面的氨基酸残基来调节抗磷脂酰肌醇蛋白聚糖3抗体的血浆半衰期的方法; 和具有通过氨基酸残基修饰调节的血浆半衰期的抗磷脂酰肌醇蛋白聚糖3抗体，包含作为活性成分的磷脂酰肌醇蛋白聚糖3抗体的药物组合物，以及制备抗磷脂酰肌醇蛋白聚糖3抗体的方法和 制备包含抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分的药物组合物。
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公开(公告)号：US11066483B2
公开(公告)日：2021-07-20
申请号：US13990088
申请日：2011-11-30
申请人： Junichi Nezu , Takahiro Ishiguro , Atsushi Narita , Akihisa Sakamoto , Yumiko Kawai , Tomoyuki Igawa , Taichi Kuramochi
发明人： Junichi Nezu , Takahiro Ishiguro , Atsushi Narita , Akihisa Sakamoto , Yumiko Kawai , Tomoyuki Igawa , Taichi Kuramochi
摘要： By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.
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