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公开(公告)号：US07776329B2
公开(公告)日：2010-08-17
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
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公开(公告)号：US07919086B2
公开(公告)日：2011-04-05
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US20100248359A1
公开(公告)日：2010-09-30
申请号：US12797349
申请日：2010-06-09
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US20070190599A1
公开(公告)日：2007-08-16
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US20090220967A1
公开(公告)日：2009-09-03
申请号：US12193654
申请日：2008-08-18
申请人： Jun-Ichi Nezu , Akira Tsuji , Asuka Ose
发明人： Jun-Ichi Nezu , Akira Tsuji , Asuka Ose
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/47 , Y10T436/143333
摘要： The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2 gene and its protein.
摘要翻译： 发现引起全身肉碱缺乏的基因是涉及有机阳离子运输的OCTN2基因。 本发明能够通过检测OCTN2基因是否具有突变来测试该疾病。 此外，可以使用正常的OCTN2基因及其蛋白质治疗系统性肉碱缺乏症。
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公开(公告)号：US20080206750A1
公开(公告)日：2008-08-28
申请号：US11800888
申请日：2007-05-08
申请人： Jun-Ichi Nezu , Asuka Ose
发明人： Jun-Ichi Nezu , Asuka Ose
摘要： Novel fetal genes (fls353 and fls485) have been successfully isolated from human fetal liver-derived cDNAs. These genes were specifically expressed in tissues including fetal tissues which are thought to contain a large number of undifferentiated cells and actively differentiating/proliferating cells. High levels of expression of these genes were observed also in a variety of cancer cells. The proteins and genes encoding the proteins can be used as the tool for developing drugs for the treatment of tumors.
摘要翻译： 已经从人胎肝来源的cDNA中成功分离出新的胎儿基因（fls353和fls485）。 这些基因在包括胎儿组织的组织中被特异性表达，所述组织被认为含有大量未分化细胞并且主动分化/增殖细胞。 在各种癌细胞中也观察到这些基因的高水平表达。 编码蛋白质的蛋白质和基因可用作开发用于治疗肿瘤的药物的工具。
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公开(公告)号：US20050020531A1
公开(公告)日：2005-01-27
申请号：US10940500
申请日：2004-09-13
申请人： Jun-Ichi Nezu , Asuka Ose
发明人： Jun-Ichi Nezu , Asuka Ose
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , A61K39/395 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/47 , Y10T436/143333
摘要： The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2 gene and its protein.
摘要翻译： 发现引起全身肉碱缺乏的基因是涉及有机阳离子运输的OCTN2基因。 本发明能够通过检测OCTN2基因是否具有突变来测试该疾病。 此外，可以使用正常的OCTN2基因及其蛋白质治疗系统性肉碱缺乏症。
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公开(公告)号：US07947470B2
公开(公告)日：2011-05-24
申请号：US10762154
申请日：2004-01-21
申请人： Jun-Ichi Nezu , Asuka Oku
发明人： Jun-Ichi Nezu , Asuka Oku
CPC分类号： C07K14/47
摘要： Novel genes significantly homologous to organic cation transporters OCT1 and OCT2 have been successfully isolated by screening a fetal gene library by random sequencing. Proteins encoded by these genes function as transporters of various organic cations.
摘要翻译： 通过随机测序筛选胎儿基因文库，成功地分离了与有机阳离子转运蛋白OCT1和OCT2显着同源的新基因。 由这些基因编码的蛋白质作为各种有机阳离子的转运体起作用。
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公开(公告)号：US07214774B2
公开(公告)日：2007-05-08
申请号：US11182592
申请日：2005-07-14
申请人： Jun-Ichi Nezu , Asuka Ose
发明人： Jun-Ichi Nezu , Asuka Ose
摘要： Novel fetal genes (fls353 and fls485) have been successfully isolated from human fetal liver-derived cDNAs. These genes were specifically expressed in tissues including fetal tissues which are thought to contain a large number of undifferentiated cells and actively differentiating/proliferating cells. High levels of expression of these genes were observed also in a variety of cancer cells. The proteins and genes encoding the proteins can be used as the tool for developing drugs for the treatment of tumors.
摘要翻译： 已经从人胎肝来源的cDNA中成功分离出新的胎儿基因（fls353和fls485）。 这些基因在包括胎儿组织的组织中被特异性表达，所述组织被认为含有大量未分化细胞并且主动分化/增殖细胞。 在各种癌细胞中也观察到这些基因的高水平表达。 编码蛋白质的蛋白质和基因可用作开发用于治疗肿瘤的药物的工具。
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公开(公告)号：US07045316B2
公开(公告)日：2006-05-16
申请号：US10101921
申请日：2002-03-20
申请人： Jun-Ichi Nezu , Asuka Ose , Akira Tsuji
发明人： Jun-Ichi Nezu , Asuka Ose , Akira Tsuji
CPC分类号： C07K14/47 , C07K14/705 , C12Q1/6883
摘要： Four novel transporter genes were successfully cloned by screening novel transporter genes based on the human OATP transporter gene sequence. These transporters are useful in the development of drugs by taking advantage of the activity of transporting biological substances and various drugs. It was also found that these transporter genes have single nucleotide polymorphisms (SNP). Gene diagnosis based on the polymorphisms (such as SNP) in these transporter genes enables one to judge, for example, the efficacy of a drug therapy.
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