摘要:
Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino) thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).
摘要:
A compound of the formula: ##STR1## wherein X is .dbd.N--A--R.sup.1 or .dbd.C(R.sup.1)R.sup.2 ; A is a single bond, polymethylerie or --CO--; R.sup.1 and R.sup.2 are each hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, unsubstituted or substituted phenyl, optionally substituted benzhydryl, or optionally substituted 5 to 6 membered heterocyclic group; Y is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 alkoxy, optionally substituted phenoxy, optionally substituted benzyloxy, or optionally substituted benzyl; Z is hydrogen or acyl; n is an integer of from 2 to 6, and pharmaceutically acceptable salt thereof. A pharmaceutical composition containing the compound, which is useful for treating hypertension and cardiac diseases, is also provided.
摘要:
A compound of the formula: ##STR1## wherein X is .dbd.N--A--R.sup.1 or .dbd.C(R.sup.1)R.sup.2 ; A is a single bond, polymethylene or --CO--; R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, unsubstituted or substituted phenyl, optionally substituted benzhydryl, or optionally substituted 5 to 6 membered heterocyclic group; Y is hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, optionally substituted phenoxy, optionally substituted benzyloxy, or optionally substituted benzyl; Z is hydrogen or acyl; n is an integer of from 2 to 6, and pharmaceutically acceptable salt thereof. A pharmaceutical composition containing the compound, which is useful for treating hypertension and cardiac diseases, is also provided.
摘要:
According to the present invention, a porous material for a fuel cell electrolyte membrane, wherein at least one strength auxiliary layer is provided inside and/or on the surface of a high porosity layer, the high porosity layer and the strength auxiliary layer constitute a multilayer structure, and the average diameter of pores of the high porosity layer is different from the average diameter of pores of the strength auxiliary layer, is provided. Also, a porous material having high porosity and high strength, which is suitable as a base material for an electrolyte membrane of a solid polymer fuel cell, is provided and a high-performance fuel cell using such material is realized.
摘要:
Disclosed is a wireless communication system and the like that can avoid interference even if a plurality of networks coexist. The wireless communication system includes a primary user, cluster head equipment, and a secondary user. The cluster head equipment is for providing a local area network to a cluster region containing the abovementioned primary user. Also, the cluster head equipment contains: an acquisition means that acquires one or both—of information regarding the primary user and information regarding a primary signal—and the like; and a transmission means that transmits information to the secondary user. Then, using this wireless communication system, the secondary user performs cognitive wireless communication or the like on the basis of the information received from the transmission means of the cluster head equipment.
摘要:
There is disclosed a channel adjusting method capable of suppressing the occurrence of interference between a cognitive pilot channel (CPC) and an auxiliary control channel (ACS) in cognitive wireless communications. According to the channel adjusting method for use in cognitive wireless communications, initially, a connection using a cognitive pilot channel (CPC) is set up. Thereafter, it is determined whether or not a spectrum sensing channel (ACS) is to be utilized. If yes, it is then determined whether or not any interference occurs between the spectrum sensing channel (ACS) and the set-up cognitive pilot channel (CPC). This allows an adjustment to be performed such that no interference occurs between the cognitive pilot channel (CPC) and the spectrum sensing channel (ACS).
摘要:
A heating section 20 having heating elements using carbon which generates heat when a high-frequency electric current is fed to a coil whose pitch can be adjusted as desired is arranged in a heating chamber 10. A cooling chamber 80 configured to cool metal is disposed below the heating chamber 10 in communication with the heating chamber 10 via a connection section 60. A water-cooled vertically movable shaft 90 which is capable of supporting the metal to be heat-treated and entering the heating chamber 10 is disposed so as to penetrate through the bottom portion of the cooling chamber 80. A gas introducing pipe 81 configured to introduce gas for cooling heated metal to be heat-treated supported by the water-cooled vertically movable shaft 90 and moved from the heating chamber 10 to the cooling chamber 80 is disposed in the cooling chamber 80.
摘要:
An object of the present invention is to provide a game apparatus that can display an avatar matched to any kind of game in which the avatar participates, without changing clothes or decorations worn by the avatar to new clothes or decorations. The game apparatus specifies display data of items based on attributes set to the items and includes a design table where a correspondence relationship between the attributes and the display data of the items is set. Display data of the player character is generated based on the specified display data of the items, and the player character is displayed on a display screen based on the generated display data of the player character.
摘要:
Provided is a spectrum sensor for cognitive wireless communication whereby it is possible to improve communication efficiency. In a cognitive wireless communication system, a spectrum sensor senses spectra in multiple frequency bands. A spectrum sensor is configured to be able to operate in one operation mode selected from among a spectrum sensing mode for sensing spectra, and a communication mode for communicating with a wireless communication device. Further, the spectrum sensor is provided with a controller for controlling the operation mode. The controller switches between the above-mentioned operation modes during the symbol period of an ultra-wideband physical layer (UWB PHY).
摘要:
An interference preventing method prevents communication interference between two or more wireless communication networks having mutually different physical layers, in which wireless communication is performed between a plurality of devices and a coordinator. By using a coordinator of each of the wireless communication networks, a scanning period for scanning a coexistence notification signal that is transmitted from a coordinator of another wireless communication network for a predetermined period is arranged before a first super frame immediately after input of power. The CB of the coordinator is transmitted at least once or more for one super frame, and, in a case where the CB transmitted from the coordinator of the other wireless communication network is acquired during the scanning period, control for preventing communication interference with the other wireless communication network is performed.