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    Cell having modified cell membrane
    1.
    发明授权
    Cell having modified cell membrane 有权
    细胞具有改变的细胞膜

    公开(公告)号：US07198945B2

    公开(公告)日：2007-04-03

    申请号：US10211587

    申请日：2002-08-05

    申请人： Teruyuki Nagamune ,  Chika Itoh ,  Tohru Yasukohchi ,  Syunsuke Ohhashi ,  Kazuhiro Kubo

    发明人： Teruyuki Nagamune ,  Chika Itoh ,  Tohru Yasukohchi ,  Syunsuke Ohhashi ,  Kazuhiro Kubo

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0006

    摘要： A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).

    摘要翻译： 其中待修饰物质和两亲性化合物的反应产物与细胞膜非共价结合的细胞，其中所述化合物具有以下特征

    Phospholipid derivative
    2.
    发明授权
    Phospholipid derivative 有权
    磷脂衍生物

    公开(公告)号：US07399877B2

    公开(公告)日：2008-07-15

    申请号：US10549630

    申请日：2004-03-19

    申请人： Chika Itoh ,  Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    发明人： Chika Itoh ,  Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    IPC分类号： C07F9/02

    CPC分类号： A61K9/127 ,  C07F9/10 ,  C11D1/345

    摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome

    摘要翻译： 由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数， 符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性 的脂质体

    Phospholipid derivative
    3.
    发明授权
    Phospholipid derivative 有权
    磷脂衍生物

    公开(公告)号：US07495116B2

    公开(公告)日：2009-02-24

    申请号：US10508704

    申请日：2003-03-28

    申请人： Chika Itoh ,  Kazuhiro Kubo ,  Syunsuke Ohhashi ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    发明人： Chika Itoh ,  Kazuhiro Kubo ,  Syunsuke Ohhashi ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    IPC分类号： C07C9/02

    CPC分类号： A61K47/24 ,  A61K8/14 ,  A61K8/553 ,  A61K8/556 ,  A61K8/86 ,  A61K9/1271 ,  A61Q19/00 ,  C07F9/10 ,  C08G65/2609 ,  C08G65/3353

    摘要： A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3≦m≦200, 9≦m×(k1+k2+k3)≦1000, 1≦k1≦2, 0≦k2≦9 and 0≦k3≦9, and 3≦k1+k2+k3≦10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.

    摘要翻译： 由式（1）表示的磷脂衍生物（Z表示具有3〜10个羟基的化合物的残基; AO表示碳原子数2〜4的氧化烯基）; R1CO和R2CO表示碳原子数为8〜22的酰基 ; X表示氢原子，碱金属原子，铵或有机铵;“a”表示0〜4的整数，“b”表示0或1; Q表示氢原子或甲基; m表示 氧化亚烷基的摩尔数; m，k1，k2和k3是满足以下条件的数：3 <= m <= 200,9 [= mx（k1 + k2 + k3）<= 1000,1 1 = <= 2，0 <= k2 <= 9，0 <= k3 <= 9，3 <= k1 + k2 + k3 = 10），对生物体来说安全性高，适用于溶解分散 的生理活性物质等，或药物递送系统如脂质体和化妆品领域。

    Phospholipid derivative
    6.
    发明申请
    Phospholipid derivative 有权
    磷脂衍生物

    公开(公告)号：US20060110436A1

    公开(公告)日：2006-05-25

    申请号：US10529692

    申请日：2003-09-30

    申请人： Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Chika Itoh ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Kurosawa ,  Hitoshi Yamauchi

    发明人： Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Chika Itoh ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Kurosawa ,  Hitoshi Yamauchi

    IPC分类号： A61K31/795 ,  C08F291/00 ,  A61K9/127

    CPC分类号： C08F8/40 ,  A61K8/14 ,  A61K8/8164 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K31/795 ,  A61Q19/00 ,  C08F220/28 ,  C08F222/06 ,  C08L53/00 ,  C08F222/04 ,  C08L2666/02

    摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.

    摘要翻译： 可用于脂质体改性的磷脂衍生物等，其是以式（1）表示的成分单元A，式（2A）表示的成分单元B和/或式 式（2B）和式（3）表示的成分单元C [R 1和R 2]表示氢原子或甲基，条件是R 0 > 1 和R 2不同时表示甲基; R 3表示具有1至3个碳原子的二价烃基; AO表示碳原子数2〜4的氧化烯基， m表示加成的氧化烯基的平均摩尔数，是在4≤M≤100的范围内的数字; R 4表示氢原子，碳原子数为1〜20的烃基或酰基， R 5 CO和R 6 CO表示具有8至24个碳原子的酰基; R 7表示具有2至4个碳原子的二价烃基; 并且X和Y表示氢原子，碱金属原子，铵或有机铵]，其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7，组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。

    Phospolipid derivative
    7.
    发明申请
    Phospolipid derivative 有权
    磷脂衍生物

    公开(公告)号：US20070031481A1

    公开(公告)日：2007-02-08

    申请号：US10549630

    申请日：2004-03-19

    申请人： Chika Itoh ,  Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    发明人： Chika Itoh ,  Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Takahashi ,  Hitoshi Yamauchi

    IPC分类号： A61K9/127 ,  A61K31/685 ,  C07F9/02

    CPC分类号： A61K9/127 ,  C07F9/10 ,  C11D1/345

    摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome.

    摘要翻译： 由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数， 符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性 的脂质体。

    Phospholipid derivative
    10.
    发明授权
    Phospholipid derivative 有权
    磷脂衍生物

    公开(公告)号：US07531604B2

    公开(公告)日：2009-05-12

    申请号：US10529692

    申请日：2003-09-30

    申请人： Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Chika Itoh ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Kurosawa ,  Hitoshi Yamauchi

    发明人： Syunsuke Ohhashi ,  Kazuhiro Kubo ,  Chika Itoh ,  Tohru Yasukohchi ,  Hiroshi Kikuchi ,  Norio Suzuki ,  Miho Kurosawa ,  Hitoshi Yamauchi

    IPC分类号： C08F8/32 ,  C08F8/40 ,  A61K9/127 ,  A61K47/32 ,  A61P35/00

    CPC分类号： C08F8/40 ,  A61K8/14 ,  A61K8/8164 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K31/795 ,  A61Q19/00 ,  C08F220/28 ,  C08F222/06 ,  C08L53/00 ,  C08F222/04 ,  C08L2666/02

    摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.

    摘要翻译： 可用于脂质体改性的磷脂衍生物等，其是以式（1）表示的成分单元A，式（2A）表示的成分单元B和/或式 式（2B）和式（3）表示的成分单元C [R1和R2表示氢原子或甲基，条件是R1和R2不同时表示甲基; R3表示碳原子数为1〜3的二价烃基; AO表示碳原子数2〜4的氧化烯基， m表示加成的氧化烯基的平均摩尔数，为4≤m≤100的范围内的数; R4表示氢原子，碳原子数为1〜20的烃基或酰基， R5CO和R6CO表示碳原子数为8〜24的酰基， R 7表示碳原子数为2〜4的二价烃基; 并且X和Y表示氢原子，碱金属原子，铵或有机铵]，其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7，组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。