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43 条记录 (耗时 0.021 秒)

    Coumarin derivative
    1.
    发明授权
    Coumarin derivative 失效
    香豆素衍生物

    公开(公告)号：US07482473B2

    公开(公告)日：2009-01-27

    申请号：US11470820

    申请日：2006-09-07

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Takuji Shoda

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Takuji Shoda

    IPC分类号： C07D405/00

    CPC分类号： C07D405/12 ,  C07D405/14

    摘要： A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence only after reacting with a thiol group.

    摘要翻译： 由以下通式（I）表示的化合物或其盐[R1表示氢原子或C1-12烷基; R2表示具有一个或多个马来酰亚胺基团的C1-12烷基，具有两个或更多个马来酰亚胺基团的芳基，由式（A）表示的基团： - （CH 2）n -CO-N（R 11）（R 12） （R11和R12表示氢原子，C1-12烷基，具有一个或多个马来酰亚胺基的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基，n表示1至6的整数）， 或由式（B）表示的基团： - （CH 2）m -NH-CO-R 13（R 13表示具有一个或多个马来酰亚胺基团的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基， m表示1〜6的整数）; R3和R5代表氢原子或卤原子; R 4表示羟基，C 1-12酰氧基，C 1-12酰氧基甲氧基或氨基]，其仅在与硫醇基反应后具有发射强荧光性质的新型荧光标记剂是有用的。

    Maleimide derivative
    2.
    发明授权
    Maleimide derivative 失效
    马来酰亚胺衍生物

    公开(公告)号：US07897787B2

    公开(公告)日：2011-03-01

    申请号：US12066323

    申请日：2006-09-13

    申请人： Takuya Matsumoto ,  Takuji Shoda ,  Yasuteru Urano ,  Tetsuo Nagano

    发明人： Takuya Matsumoto ,  Takuji Shoda ,  Yasuteru Urano ,  Tetsuo Nagano

    IPC分类号： C07F5/02

    CPC分类号： C07F5/022 ,  C09B23/04 ,  C09B57/10 ,  G01N21/6428 ,  G01N2021/6439

    摘要： A compound represented by the following general formula (I): [wherein R1 and R2 independently represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 and X2 represent hydrogen atom, an alkyl group, an alkoxy group, or a halogen atom), provided that R1 and R2 do not simultaneously represent hydrogen atom; R3 and R6 represent an alkyl group; R4 and R7 represent hydrogen atom, an alkyl group, carboxy group, an alkoxycarbonyl group, or sulfo group; and R5 and R8 represents an alkyl group, an aryl group, an alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group], or a salt thereof, which is usable for efficient screening for a chemical substance having applicability as a catalyst of the reaction of Michael addition.

    摘要翻译： 由以下通式（I）表示的化合物：[其中R 1和R 2独立地表示氢原子或由下式（A）表示的基团：（其中X 1和X 2表示氢原子，烷基，烷氧基 或卤素原子），条件是R 1和R 2不同时表示氢原子; R3和R6表示烷基; R4和R7表示氢原子，烷基，羧基，烷氧基羰基或磺基; R5和R8表示烷基，芳基，烷氧基羰基，乙烯基，噻吩基或吡咯基]或其盐，其可用于有效筛选具有适用性的化学物质作为 催化剂的迈克尔加成反应。

    NOVEL MALEIMIDE DERIVATIVE
    3.
    发明申请
    NOVEL MALEIMIDE DERIVATIVE 失效
    新浪漫主义

    公开(公告)号：US20090318707A1

    公开(公告)日：2009-12-24

    申请号：US12066323

    申请日：2006-09-13

    申请人： Takuya Matsumoto ,  Takuji Shoda ,  Yasuteru Urano ,  Tetsuo Nagano

    发明人： Takuya Matsumoto ,  Takuji Shoda ,  Yasuteru Urano ,  Tetsuo Nagano

    IPC分类号： C07F5/02

    CPC分类号： C07F5/022 ,  C09B23/04 ,  C09B57/10 ,  G01N21/6428 ,  G01N2021/6439

    摘要： A compound represented by the following general formula (I): [wherein R1 and R2 independently represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 and X2 represent hydrogen atom, an alkyl group, an alkoxy group, or a halogen atom), provided that R1 and R2 do not simultaneously represent hydrogen atom; R3 and R6 represent an alkyl group; R4 and R7 represent hydrogen atom, an alkyl group, carboxy group, an alkoxycarbonyl group, or sulfo group; and R5 and R8 represents an alkyl group, an aryl group, an alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group], or a salt thereof, which is usable for efficient screening for a chemical substance having applicability as a catalyst of the reaction of Michael addition.

    摘要翻译： 由以下通式（I）表示的化合物：[其中R 1和R 2独立地表示氢原子或由下式（A）表示的基团：（其中X 1和X 2表示氢原子，烷基，烷氧基 或卤素原子），条件是R 1和R 2不同时表示氢原子; R3和R6表示烷基; R4和R7表示氢原子，烷基，羧基，烷氧基羰基或磺基; R5和R8表示烷基，芳基，烷氧基羰基，乙烯基，噻吩基或吡咯基]或其盐，其可用于有效筛选具有适用性的化学物质作为 催化剂的迈克尔加成反应。

    NOVEL COUMARIN DERIVATIVE
    4.
    发明申请
    NOVEL COUMARIN DERIVATIVE 失效
    新古典衍生物

    公开(公告)号：US20070197778A1

    公开(公告)日：2007-08-23

    申请号：US11470820

    申请日：2006-09-07

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Takuji Shoda

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Takuji Shoda

    IPC分类号： C07K14/47 ,  C07D405/14

    CPC分类号： C07D405/12 ,  C07D405/14

    摘要： A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence only after reacting with a thiol group.

    摘要翻译： 由下列通式（I）表示的化合物或其盐[R 1]表示氢原子或C 1-12烷基; R 2表示具有一个或多个马来酰亚胺基团的碳原子数为1〜12的烷基，具有两个以上马来酰亚胺基团的芳基，式（A）所示的基团， ：（CH 2）n -CO-N（R 11）（R 12）（R 12） SUP 11和R 12代表氢原子，C 1-12烷基，C 1-12烷基 具有一个或多个马来酰亚胺基团或具有一个或多个马来酰亚胺基团的芳基，n表示1至6的整数）或由式（B）表示的基团： - （CH 2）2 >）-NH-CO-R 13（R 13）表示C 1-12烷基，其具有 一个或多个马来酰亚胺基团或具有一个或多个马来酰亚胺基团的芳基，m表示1至6的整数）; R 3和R 5代表氢原子或卤素原子; R 4表示羟基，C 1-12酰氧基，C 1-12酰氧基甲氧基或氨基]，其中 作为具有仅与硫醇基反应后发出强荧光的性质的新型荧光标记剂是有用的。

    NOVEL COUMARIN DERIVATIVES
    5.
    发明申请
    NOVEL COUMARIN DERIVATIVES 审中-公开
    新型欧姆龙衍生物

    公开(公告)号：US20090118471A1

    公开(公告)日：2009-05-07

    申请号：US12337327

    申请日：2008-12-17

    申请人： Tetsuo NAGANO ,  Yasuteru Urano ,  Takuji Shoda

    发明人： Tetsuo NAGANO ,  Yasuteru Urano ,  Takuji Shoda

    IPC分类号： C07K1/107 ,  C07D405/14

    CPC分类号： C07D405/12 ,  C07D405/14

    摘要： A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence only after reacting with a thiol group.

    摘要翻译： 由以下通式（I）表示的化合物或其盐[R1表示氢原子或C1-12烷基; R2表示具有一个或多个马来酰亚胺基团的C1-12烷基，具有两个或更多个马来酰亚胺基团的芳基，由式（A）表示的基团： - （CH 2）n -CO-N（R 11）（R 12） （R11和R12表示氢原子，C1-12烷基，具有一个或多个马来酰亚胺基的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基，n表示1至6的整数）， 或由式（B）表示的基团： - （CH 2）m -NH-CO-R 13（R 13表示具有一个或多个马来酰亚胺基团的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基， m表示1〜6的整数）; R3和R5代表氢原子或卤原子; R 4表示羟基，C 1-12酰氧基，C 1-12酰氧基甲氧基或氨基]，其仅在与硫醇基反应后具有发射强荧光性质的新型荧光标记剂是有用的。

    Reagent for measuring active nitrogen
    7.
    发明授权
    Reagent for measuring active nitrogen 有权
    用于测量活性氮的试剂

    公开(公告)号：US08895317B2

    公开(公告)日：2014-11-25

    申请号：US13131173

    申请日：2009-12-04

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Saki Izumi

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Saki Izumi

    IPC分类号： G01N33/48 ,  C07D311/82 ,  G01N31/22

    CPC分类号： G01N31/22 ,  Y10T436/170769 ,  Y10T436/173076 ,  Y10T436/177692 ,  Y10T436/178459 ,  Y10T436/179228

    摘要： A compound represented by the general formula (I) [R1 and R2 are amino groups that substitute at adjacent positions on the benzene ring; R3 and R4 are halogen atoms; R5 and R6 represent hydrogen atom, an acyl group or an acyloxy(C1-6 alkyl) group; R7 and R8 represent —(CH2)p—N(R9)(R10) (p is 1 to 4, and R9 and R10 represent —(CH2)n—COOH (n is 1 to 4))], which is useful for measuring a reactive nitrogen species existing in cells such as nitrogen monoxide or peroxynitrite at high sensitivity over a long period of time.

    摘要翻译： 由通式（I）表示的化合物[R1和R2是在苯环上的相邻位置取代的氨基; R3和R4是卤素原子; R5和R6代表氢原子，酰基或酰氧基（C1-6烷基）基团; R7和R8表示 - （CH2）p-N（R9）（R10）（p为1至4，R9和R10表示 - （CH2）n-COOH（n为1至4））] 在长时间内以高灵敏度测量存在于细胞中的活性氮物质，例如一氧化氮或过氧亚硝酸盐。

    Fluorescent probe for measurement of UDP-glucuronosyltransferase
    10.
    发明授权
    Fluorescent probe for measurement of UDP-glucuronosyltransferase 有权
    用于测量UDP-葡糖醛酸基转移酶的荧光探针

    公开(公告)号：US08309319B2

    公开(公告)日：2012-11-13

    申请号：US12527793

    申请日：2008-02-26

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Rie Tomiyasu

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Rie Tomiyasu

    IPC分类号： C12Q1/48

    CPC分类号： G01N33/582 ,  C12Q1/48

    摘要： A fluorescent probe for measurement of UDP-glucuronosyltransferase, which comprises a fluorescein derivative, wherein in the fluorescein derivative, the 2-carboxy group on the benzene ring of fluorescein is replaced with another monovalent substituent, provided that said substituent is a substituent other than sulfo group, and the substituent does not have carboxy group or sulfo group, and wherein the fluorescein derivative may have an arbitrary substituent at a position on the benzene ring other than the 2-position, and the fluorescein derivative may have a substituent selected from the group consisting of an alkoxy group and a halogen atom at the 2-position and/or the 7-position of fluorescein.

    摘要翻译： 用于测量UDP-葡糖醛酸基转移酶的荧光探针，其包含荧光素衍生物，其中在荧光素衍生物中，荧光素的苯环上的2-羧基被另外的一价取代基取代，条件是所述取代基是除磺基以外的取代基 并且取代基不具有羧基或磺基，并且其中所述荧光素衍生物在除2-位之外的苯环上的位置可以具有任意的取代基，并且所述荧光素衍生物可以具有选自下列基团的取代基 由荧光素的2-位和/或7-位上的烷氧基和卤素原子组成。