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    PROMOTER FOR BICARBONATE SECRETION IN GASTROINTESTINAL TRACT
    1.
    发明申请
    PROMOTER FOR BICARBONATE SECRETION IN GASTROINTESTINAL TRACT 审中-公开
    促进剂在胃肠道分泌物中的分离

    公开(公告)号：US20110071075A1

    公开(公告)日：2011-03-24

    申请号：US12888479

    申请日：2010-09-23

    申请人： Koji Takeuchi ,  Eitaro Aihara ,  Eiji Nakamura ,  Tetsuo Yano ,  Mai Hasumura ,  Hisayuki Uneyama

    发明人： Koji Takeuchi ,  Eitaro Aihara ,  Eiji Nakamura ,  Tetsuo Yano ,  Mai Hasumura ,  Hisayuki Uneyama

    IPC分类号： A61K38/00 ,  A61P3/04 ,  A61K31/195 ,  A61K31/135 ,  A61P1/04

    CPC分类号： A61K31/198 ,  A61K31/137 ,  A61K38/05 ,  A61K38/06 ,  A61K45/06 ,  C07K5/0215 ,  C07K5/06043 ,  C07K5/0606 ,  C07K5/06104 ,  C07K5/0819 ,  A61K2300/00

    摘要： A substance is described which can prevent or treat a disease associated with the secretion of an acid. A calcium receptor activator is the active ingredient in a composition which promotes bicarbonate secretion in a gastrointestinal tract. Examples of the calcium receptor activator include γ-Glu-X-Gly, wherein X represents an amino acid or an amino acid derivative, γ-Glu-Val-Y, wherein Y represents an amino acid or an amino acid derivative, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, and γ-Glu-Cys(S-Me).

    摘要翻译： 描述了可以预防或治疗与分泌酸相关的疾病的物质。 钙受体激活剂是促进胃肠道中碳酸氢盐分泌的组合物中的活性成分。 钙受体活化剂的实例包括γ-Glu-X-Gly，其中X表示氨基酸或氨基酸衍生物，γ-Glu-Val-Y，其中Y表示氨基酸或氨基酸衍生物，γ-Glu -Ala，γ-Glu-Gly，γ-Glu-Cys，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met ，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu和γ-Glu-Cys （S-Me）。

    PREVENTIVE/THERAPEUTIC AGENT FOR VISCERAL PAIN
    2.
    发明申请
    PREVENTIVE/THERAPEUTIC AGENT FOR VISCERAL PAIN 审中-公开
    用于粘膜疼痛的预防/治疗剂

    公开(公告)号：US20070249717A1

    公开(公告)日：2007-10-25

    申请号：US11740541

    申请日：2007-04-26

    申请人： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

    发明人： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

    IPC分类号： A61K31/198

    CPC分类号： A61K31/198 ,  A23L33/175

    摘要： The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.

    摘要翻译： 本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。 使用预防或治疗剂，可以治疗或预防伴随内脏痛，诸如肠障，肠易激综合征，功能性消化不良，胃食管疾病，功能性腹痛综合征，溃疡性结肠炎和克罗恩病等的胃肠道疾病。 此外，还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂，食物和饮料和膳食补充剂。 与现有的药剂相比，它们与胃肠道疾病相关的内脏痛具有高度的效果，显示出减少的副作用，并且是非常有效的。

    Method and apparatus for engraving
    6.
    发明授权
    Method and apparatus for engraving 失效
    雕刻方法和装置

    公开(公告)号：US06465756B2

    公开(公告)日：2002-10-15

    申请号：US09790534

    申请日：2001-02-23

    申请人： Yasuhiro Tanaka ,  Shosuke Miyaki ,  Tetsuo Yano

    发明人： Yasuhiro Tanaka ,  Shosuke Miyaki ,  Tetsuo Yano

    IPC分类号： B23K2600

    CPC分类号： B44B5/0066

    摘要： A laser beam 7 from an engravement portion softening mechanism 6 of an apparatus is condensed onto an engravement portion on an engravement surface of a workpiece 1 for softening the engravement portion. When the hardness of the engravement portion is lowered, a pen tip 2 of the apparatus is applied to the engravement portion. Thus, it is possible to reduce reliably wear and damage of the pen tip 2 which results from engraving a hard workpiece, and to prolong the useful life of the pen tip 2, so that the durability and the reliability of the apparatus are improved.

    摘要翻译： 来自设备的雕刻部分软化机构6的激光束7被冷凝到工件1的雕刻表面上的雕刻部分上，用于软化雕刻部分。 当雕刻部分的硬度降低时，该装置的笔尖2被施加到雕刻部分。 因此，可以可靠地减少由刻印硬质工件引起的笔尖2的磨损和损伤，并且延长笔尖2的使用寿命，从而提高了装置的耐久性和可靠性。

    PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIARRHEA
    9.
    发明申请
    PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIARRHEA 审中-公开
    用于DIARRHEA的预防或治疗药物

    公开(公告)号：US20100105864A1

    公开(公告)日：2010-04-29

    申请号：US12613727

    申请日：2009-11-06

    申请人： Junya Yoneda ,  Tetsuo Yano ,  Yukie Seki ,  Yuzuru Eto ,  Yusuke Amino

    发明人： Junya Yoneda ,  Tetsuo Yano ,  Yukie Seki ,  Yuzuru Eto ,  Yusuke Amino

    IPC分类号： C07K5/08 ,  C07C211/02 ,  C07K2/00 ,  C07K4/00 ,  C07K5/06

    CPC分类号： A61K31/137 ,  A61K38/00 ,  C07K5/0215 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/0606 ,  C07K5/06104 ,  C07K5/06113

    摘要： A compound which is able to activate a calcium receptor can be used as an active ingredient of a prophylactic or therapeutic agent for treating diarrhea. The compound can be a peptide such as γ-Glu-X-Gly (X represents an amino acid or an amino acid derivative), γ-Glu-Val-Y (Y represents an amino acid or an amino acid derivative), γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, and γ-Glu-Cys(S-Me).

    摘要翻译： 能够激活钙受体的化合物可以用作治疗腹泻的预防或治疗剂的活性成分。 该化合物可以是γ-Glu-X-Gly（X表示氨基酸或氨基酸衍生物），γ-Glu-Val-Y（Y表示氨基酸或氨基酸衍生物），γ- Glu-Ala，γ-Glu-Gly，γ-Glu-Cys，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly， Met，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- -Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu和γ-Glu- Cys（S-Me）。