公开(公告)号：US5038884A

公开(公告)日：1991-08-13

申请号：US221293

申请日：1988-07-19

申请人： Tetsurou Hamada ,  Kazuhiko Shimada ,  Shoji Tokushima ,  Makoto Watanabe ,  Naoya Akama ,  Masami Takano ,  Shinji Sakuma ,  Yoshinobu Ezure

发明人： Tetsurou Hamada ,  Kazuhiko Shimada ,  Shoji Tokushima ,  Makoto Watanabe ,  Naoya Akama ,  Masami Takano ,  Shinji Sakuma ,  Yoshinobu Ezure

IPC分类号： B60K17/35 ,  B60K23/08 ,  F16D11/10 ,  F16D27/118

CPC分类号： F16D11/10 ,  B60K17/35 ,  B60K23/08 ,  F16D27/118 ,  F16D2011/006 ,  F16D2011/008

摘要： A dog clutch mechanism for use as a clutch for switching drive power in a four-wheel-drive vehicle has a case, first and second rotatable shafts rotatably supported coaxially in the case for transmitting a relative torque between front and rear wheels of the vehicle, and a dog clutch comprising a dog piece having first dog teeth and fixedly mounted on the first rotatably shaft and a hub having second dog teeth capable of axially meshing with the first dog teeth and axially slidably mounted on the second rotatable shaft. The dog clutch is selectively engageable for transmitting the relative torque between the first and second rotatable shafts. The first and second dog teeth having respective meshing tapered surfaces for producing thrust forces acting on the hub and tending to move the hub in a direction away from the dog piece when the vehicle is braked while a relative forward torque is being transmitted between the first and second rotatable shafts through the dog clutch.

公开(公告)号：US06368631B1

公开(公告)日：2002-04-09

申请号：US09452371

申请日：1999-12-01

申请人： Mitsuru Akashi ,  Akio Kishida ,  Shinji Sakuma ,  Hiroshi Kikuchi

发明人： Mitsuru Akashi ,  Akio Kishida ,  Shinji Sakuma ,  Hiroshi Kikuchi

IPC分类号： A61K914

CPC分类号： A61K47/32 ,  A61K9/1635

摘要： The present invention is directed to particulate carriers useful as drug carriers in a drug delivery system (DDS) and to pharmaceutical compositions making use of such carriers. The invention is characterized by the use, as the particulate carrier, of: graft copolymer (A) whose graft chain is poly N-alkylacrylamide chain, poly N-alkylmethacrylamide chain, etc.; and a composition containing a combination of the graft copolymer (A) and at least one graft copolymers selected from the group consisting of graft copolymers (B-1) having polyacrylic acid or polymethacrylic acid as the graft chain and graft copolymers (B-2) having a polyvinyl amine compound as the graft chain.

摘要翻译： 本发明涉及用作药物递送系统（DDS）中的药物载体的颗粒载体和利用这种载体的药物组合物。 本发明的特征在于使用接枝共聚物（A）作为颗粒载体，其接枝链是聚N-烷基丙烯酰胺链，聚N-烷基甲基丙烯酰胺链等; 和含有接枝共聚物（A）和至少一种选自具有聚丙烯酸或聚甲基丙烯酸作为接枝链的接枝共聚物（B-1）和接枝共聚物（B-2）的组合的组合物， 具有聚乙烯胺化合物作为接枝链。

公开(公告)号：US08735177B2

公开(公告)日：2014-05-27

申请号：US11918465

申请日：2007-02-20

申请人： Shinji Sakuma ,  Shinji Yamashita ,  Ken-Ichiro Hiwatari ,  Yoshikazu Shoji

发明人： Shinji Sakuma ,  Shinji Yamashita ,  Ken-Ichiro Hiwatari ,  Yoshikazu Shoji

IPC分类号： G01N33/547 ,  G01N33/544

CPC分类号： A61K49/0039 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0093

摘要： A diagnostic marker is composed of particles that have a diameter of from 1 nm to 100 μm, the particles possessing on their surfaces a site that has a high specific bonding ability to a specific antigen residing on the mucosa of digestive cancers and a site that has a low bonding ability to the mucosa of digestive organs, and further incorporating an identification material.

摘要翻译： 诊断标记由直径为1nm至100μm的颗粒组成，颗粒在其表面上具有与存在于消化性癌症粘膜上的特异性抗原具有高特异性结合能力的位点，以及具有 对消化器官粘膜的粘合能力低，并进一步掺入鉴定材料。

公开(公告)号：US6100338A

公开(公告)日：2000-08-08

申请号：US101804

申请日：1998-08-21

申请人： Mitsuru Akashi ,  Akio Kishida ,  Shinji Sakuma ,  Hiroshi Kikuchi

发明人： Mitsuru Akashi ,  Akio Kishida ,  Shinji Sakuma ,  Hiroshi Kikuchi

IPC分类号： C08F220/56 ,  A61K9/16 ,  A61K47/30 ,  A61K47/32 ,  C08F220/00 ,  C08F220/02 ,  C08F220/10 ,  A61K9/14

CPC分类号： A61K47/32 ,  A61K9/1635

摘要： The present invention is directed to particulate carriers useful as drug carries in a drug delivery system (DDS) and to pharmaceutical compositions making use of such carriers. The invention is characterized by the use, as the particulate carrier, of: graft copolymer (A) whose graft chain is poly N-alkylacrylamide chain, poly N-alkylmethacrylamide chain, etc.; and composition containing a combination of the graft copolymer (A) and at least one graft copolymer selected from the group consisting of graft copolymers (B-1) having polyacrylic acid or polymethacrylic acid as the graft chain and graft copolymers (B-2) having a polyvinyl amine compound as the graft chain.

摘要翻译： PCT No.PCT / JP97 / 00463 Sec。 371日期1998年8月21日 102（e）日期1998年8月21日PCT提交1997年2月20日PCT公布。 出版物WO97 / 30730 日期：1997年8月28日本发明涉及用作药物递送系统（DDS）中的药物载体的颗粒载体和利用这些载体的药物组合物。 本发明的特征在于使用接枝共聚物（A）作为颗粒载体，其接枝链是聚N-烷基丙烯酰胺链，聚N-烷基甲基丙烯酰胺链等; 和含有接枝共聚物（A）和至少一种选自具有聚丙烯酸或聚甲基丙烯酸作为接枝链的接枝共聚物（B-1）和至少具有接枝共聚物（B-2）的接枝共聚物 聚乙烯胺化合物作为接枝链。

公开(公告)号：US20090075301A1

公开(公告)日：2009-03-19

申请号：US11918465

申请日：2007-02-20

申请人： Shinji Sakuma ,  Shinji Yamashita ,  Ken-ichiro Hiwatari ,  Yoshikazu Shoji

发明人： Shinji Sakuma ,  Shinji Yamashita ,  Ken-ichiro Hiwatari ,  Yoshikazu Shoji

IPC分类号： G01N33/574 ,  G01N33/53

CPC分类号： A61K49/0039 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0093

摘要： A diagnostic marker is composed of particles that have a diameter of from 1 nm to 100 μm, the particles possessing on their surfaces a site that has a high specific bonding ability to a specific antigen residing on the mucosa of digestive cancers and a site that has a low bonding ability to the mucosa of digestive organs, and further incorporating an identification material.

摘要翻译： 诊断标记由直径为1nm至100μm的颗粒组成，颗粒在其表面上具有对存在于消化性癌症粘膜上的特异性抗原具有高特异性结合能力的位点，以及具有 对消化器官粘膜的粘合能力低，并进一步掺入鉴定材料。

公开(公告)号：US06460331B2

公开(公告)日：2002-10-08

申请号：US09729688

申请日：2000-12-06

申请人： Shinji Sakuma ,  Takashi Nakamura ,  Takaki Yamaoka

发明人： Shinji Sakuma ,  Takashi Nakamura ,  Takaki Yamaoka

IPC分类号： F16D3300

CPC分类号： F16D33/06

摘要： An oil passageway 102 for suppling oil to a torque converter 30 having a pump impeller, a turbine runner and a stator 33, or removing it therefrom is formed between the shaft member 41 of a stator shaft 40 and the boss portion 42a of its flange member 42 and extends along a transmission input shaft 20, while a pump impeller boss member 31a has an outer periphery supported facing the pump impeller boss member 31a and situated closer to the stator 33 than that portion of the pump impeller boss member 31a which is supported by the bearing and the oil passageway 102 has its openings 40b and 40c situated closer to the stator 33 than that portion of the pump impeller boss member 31a which is supported by the bearing.

摘要翻译： 在定子轴40的轴构件41和凸缘部分42a之间形成用于向具有泵叶轮，涡轮转子和定子33的变矩器30提供油或从其中移除油的油通道102， 42并且沿着变速器输入轴20延伸，同时泵叶轮毂构件31a具有面向泵叶轮毂构件31a的外周，并且位于更靠近定子33的位置，比泵叶轮毂构件31a的部分更靠近 轴承和油通道102具有比由轴承支撑的泵叶轮毂部件31a更靠近定子33的开口40b和40c。