公开(公告)号：US07635798B2

公开(公告)日：2009-12-22

申请号：US10487901

申请日：2002-08-30

申请人： Thaddeus Weglarz ,  Daniel Gachotte ,  Beth Blakeslee ,  Ignacio Larrinua ,  David A. McCrery ,  Randy J. Pell ,  J. Vincent B. Oriedo ,  Barbara A. Miller ,  Avutu S. Reddy ,  Vipula Shukla ,  Rodney Crosley

发明人： Thaddeus Weglarz ,  Daniel Gachotte ,  Beth Blakeslee ,  Ignacio Larrinua ,  David A. McCrery ,  Randy J. Pell ,  J. Vincent B. Oriedo ,  Barbara A. Miller ,  Avutu S. Reddy ,  Vipula Shukla ,  Rodney Crosley

IPC分类号： C12N15/00 ,  C12N15/82 ,  C12N15/87 ,  C12N15/05 ,  C12N15/11 ,  C12N15/29 ,  A01H5/00

CPC分类号： C07K14/415 ,  C12N15/8243

摘要： This invention encompasses the identification and isolation genes and gene fragments that confer altered metabolic characteristics in Nicotiana benthamiana plants, when expressed using GENEWARE™ viral vectors. These genes are derived from a variety of sources. Expression of these genes resulted in alterations of the levels of at least one of the following metabolites: acids, fatty acids, amino acids and related compounds, branched fatty acids, carbohydrates, hydrocarbons, alkaloids and other bases, esters, glycerides, phenols and related compounds, alcohols, alkenes and alkynes, sterols, oxygenated terpenes, and other isoprenoids, and ketones and quinones.

摘要翻译： 本发明包括当使用GENEWARE TM病毒载体表达时，鉴定和分离基因和基因片段，其赋予本烟草属植物中改变的代谢特征。 这些基因来自各种来源。 这些基因的表达导致以下代谢物中的至少一种的水平的改变：酸，脂肪酸，氨基酸和相关化合物，支链脂肪酸，碳水化合物，烃类，生物碱和其它碱，酯，甘油酯，酚和相关的 化合物，醇，烯烃和炔烃，甾醇，氧化萜烯和其它类异戊二烯，以及酮和醌。

公开(公告)号：US07291767B2

公开(公告)日：2007-11-06

申请号：US10333184

申请日：2001-07-20

申请人： J. Vincent B. Oriedo ,  David McCrery ,  Philip Savickas ,  Barbara A. Miller ,  Randy Pell ,  Ignacio M. Larrinua ,  Ted Weglarz ,  Daniel Gachotte ,  Avutu S. Reddy ,  Max Ruegger ,  Beth Blakeslee ,  Gregory P. Pogue ,  Rodney Crosley ,  Wenjin Zheng ,  Guy R. Della-Cioppa ,  Gerson Wolfe

发明人： J. Vincent B. Oriedo ,  David McCrery ,  Philip Savickas ,  Barbara A. Miller ,  Randy Pell ,  Ignacio M. Larrinua ,  Ted Weglarz ,  Daniel Gachotte ,  Avutu S. Reddy ,  Max Ruegger ,  Beth Blakeslee ,  Gregory P. Pogue ,  Rodney Crosley ,  Wenjin Zheng ,  Guy R. Della-Cioppa ,  Gerson Wolfe

IPC分类号： C12N15/29 ,  C12N15/82 ,  A01H5/00

CPC分类号： C07K14/415 ,  C12N15/8241 ,  C12N15/8243 ,  C12N15/8261 ,  G01N30/72 ,  G01N30/8617 ,  G01N30/8631 ,  G01N30/8686 ,  Y02A40/146

摘要： This invention relates to putative known and unknown deoxyribonucleic acid (DNA) and amino acid sequences identified in one or more metabolic pathways that lead to dwarfism and stunting in plants and the use of these sequences in agriculture to create dwarf varieties of any plant species. This invention also relates to nucleic acids sequences and polypeptides that produce altered metabolism phenotypes in plants.

摘要翻译： 本发明涉及在一种或多种导致植物侏儒症和发育障碍的代谢途径中鉴定的推定已知和未知的脱氧核糖核酸（DNA）和氨基酸序列，以及这些序列在农业中用于产生任何植物物种的矮化品种。 本发明还涉及在植物中产生改变的代谢表型的核酸序列和多肽。

公开(公告)号：US20050091708A1

公开(公告)日：2005-04-28

申请号：US10487901

申请日：2002-08-30

申请人： Thaddeus Weglarz ,  Daniel Gachotte ,  Beth Blakeslee ,  Ignacio Larrinua ,  David McCrery ,  Randy Pell ,  J. Oriedo ,  Barbara Miller ,  Avutu Reddy ,  Vipula Shukia ,  Rodney Crosley

发明人： Thaddeus Weglarz ,  Daniel Gachotte ,  Beth Blakeslee ,  Ignacio Larrinua ,  David McCrery ,  Randy Pell ,  J. Oriedo ,  Barbara Miller ,  Avutu Reddy ,  Vipula Shukia ,  Rodney Crosley

IPC分类号： C07K14/415 ,  C12N15/29 ,  C12N15/82 ,  A01H1/00 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C07K14/415 ,  C12N15/8243

摘要： This invention encompasses the identification and isolation genes and gene fragments that confer altered metabolic characteristics in Nicotiana benthamiana plants, when expressed using GENEWARE™ viral vectors. These genes are derived from a variety of sources. Expression of these genes resulted in alterations of the levels of at least one of the following metabolites: acids, fatty acids, amino acids and related compounds, branched fatty acids, carbohydrates, hydrocarbons, alkaloids and other bases, esters, glycerides, phenols and related compounds, alcohols, alkenes and alkynes, sterols, oxygenated terpenes, and other isoprenoids, and ketones and quinones.

摘要翻译： 本发明包括当使用GENEWARE TM病毒载体表达时，鉴定和分离基因和基因片段，其赋予本烟草属植物中改变的代谢特征。 这些基因来自各种来源。 这些基因的表达导致以下代谢物中的至少一种的水平的改变：酸，脂肪酸，氨基酸和相关化合物，支链脂肪酸，碳水化合物，烃类，生物碱和其它碱，酯，甘油酯，酚和相关的 化合物，醇，烯烃和炔烃，甾醇，氧化萜烯和其它类异戊二烯，以及酮和醌。

公开(公告)号：US11236351B2

公开(公告)日：2022-02-01

申请号：US14235435

申请日：2012-07-26

申请人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner ,  Paul Gordon Roessler

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner ,  Paul Gordon Roessler

IPC分类号： C12P7/64 ,  C12N15/82 ,  A01H6/54

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US20180135066A9

公开(公告)日：2018-05-17

申请号：US14235435

申请日：2012-07-26

申请人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： C12N15/82 ,  C12P7/64

CPC分类号： C12N15/8247 ,  A01H5/10 ,  A23L11/07 ,  A23V2002/00 ,  A61K31/202 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y203/01085

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US20140359900A1

公开(公告)日：2014-12-04

申请号：US14235435

申请日：2012-07-26

申请人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： C12N15/82 ,  C12P7/64

CPC分类号： A01H5/10 ,  A01H6/542 ,  A23L11/03 ,  A23L11/07 ,  A23V2002/00 ,  A61K31/202 ,  C12N9/1029 ,  C12N9/1288 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y203/01085

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

摘要翻译： 本发明提供了用多不饱和脂肪酸（PUFA）合成酶遗传修饰的重组宿主生物体，以及允许和/或改善宿主生物体中PUFA生产的一种或多种辅助蛋白质。 本发明还涉及制造和使用这些生物体以及从这些生物获得的产品的方法。

公开(公告)号：US20130150599A1

公开(公告)日：2013-06-13

申请号：US13698412

申请日：2011-05-17

申请人： Terence A. Walsh ,  Ann Owens Merlo ,  Daniel Gachotte ,  Paul Gordon Roessler ,  Scott Bevan ,  Jerry M. Kuner ,  James G. Metz

发明人： Terence A. Walsh ,  Ann Owens Merlo ,  Daniel Gachotte ,  Paul Gordon Roessler ,  Scott Bevan ,  Jerry M. Kuner ,  James G. Metz

IPC分类号： C12N15/82

CPC分类号： C12N15/8247 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

摘要翻译： 本发明提供了用多不饱和脂肪酸（PUFA）合酶系统和一种或多种辅助蛋白（例如，PPT酶和/或ACoAS）进行遗传修饰的重组宿主生物（例如，植物），其允许和/或改善PUFA的生产 宿主生物体。 本发明还涉及制备和使用这些生物体（例如获得PUFA）以及从这些生物（例如油和/或种子）获得的产品的方法。