公开(公告)号：US20220380534A1

公开(公告)日：2022-12-01

申请号：US17620570

申请日：2020-06-22

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  Xu WANG ,  Houliang TANG ,  Wei LI ,  Jonathan WILHELM ,  Baran SUMER

IPC: C08G65/333 ,  A61P35/00 ,  A61K9/107 ,  C08G65/334

Abstract: The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.

公开(公告)号：US20220226511A1

公开(公告)日：2022-07-21

申请号：US17614638

申请日：2020-05-28

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  Baran SUMER ,  Tian ZHAO ,  Zachary T. BENNETT

IPC: A61K49/00 ,  A61K9/107 ,  C08G81/02

Abstract: Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.

公开(公告)号：US20210338579A1

公开(公告)日：2021-11-04

申请号：US17239742

申请日：2021-04-26

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Tongyi HUANG ,  Qiang FENG ,  Baran SUMER

IPC: A61K9/107 ,  A61K47/32 ,  A61K47/34 ,  A61K31/519 ,  A61K31/5025 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.

公开(公告)号：US20130330278A1

公开(公告)日：2013-12-12

申请号：US13827197

申请日：2013-03-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Kejin ZHOU ,  Baran SUMER

IPC: A61K49/00 ,  G01N21/64

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。