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    TREATMENT OF RESTLESS LEG SYNDROME AND SLEEP DISORDERS
    6.
    发明申请
    TREATMENT OF RESTLESS LEG SYNDROME AND SLEEP DISORDERS 审中-公开
    治疗休克性综合征和睡眠障碍

    公开(公告)号：US20100160295A1

    公开(公告)日：2010-06-24

    申请号：US12614390

    申请日：2009-11-06

    申请人： Lesley PICKFORD ,  Uwe Meya ,  Mark Moran

    发明人： Lesley PICKFORD ,  Uwe Meya ,  Mark Moran

    IPC分类号： A61K31/122 ,  A61K31/485 ,  A61K31/55 ,  A61K31/48 ,  A61K31/197 ,  A61K31/195 ,  C07C205/46 ,  A61P25/00

    CPC分类号： A61K31/55 ,  A61K31/00 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/48 ,  A61K31/485 ,  C12N9/0069 ,  A61K2300/00

    摘要： Methods of preventing and/or treating at least one symptom of Restless Leg Syndrome (RLS) and its related disorders, including disorders such as periodic limb movements in sleep (PLMS) and periodic limb movement disorder (PLMD), are disclosed. The methods comprise identifying a host, afflicted with Restless Leg Syndrome (RLS) and its related disorders; and administering to the host a pharmaceutically effective amount of a 4-hydroxyphenylpyruvate dioxygenase. Also provided are methods and compositions for treating/preventing sleep disorders, and methods and compositions for improving sleep quantity and adequacy.

    摘要翻译： 公开了预防和/或治疗不宁腿综合征（RLS）及其相关疾病至少一种症状的方法，包括诸如睡眠中的周期性肢体运动（PLMS）和周期性肢体运动障碍（PLMD）等疾病。 方法包括鉴定受不宁腿综合征（RLS）及其相关疾病折磨的宿主; 并向宿主施用药学有效量的4-羟基苯基丙酮酸双加氧酶。 还提供了用于治疗/预防睡眠障碍的方法和组合物，以及用于改善睡眠量和充足性的方法和组合物。

    Oxidation process
    7.
    发明授权
    Oxidation process 失效
    氧化工艺

    公开(公告)号：US4943358A

    公开(公告)日：1990-07-24

    申请号：US323976

    申请日：1989-03-15

    申请人： Kenneth M. Dear ,  Philip J. Turner

    发明人： Kenneth M. Dear ,  Philip J. Turner

    IPC分类号： B01J19/12 ,  C07C45/00 ,  C07C45/30 ,  C07C49/784 ,  C07C49/786 ,  C07C49/813 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/46 ,  C07C309/44

    CPC分类号： C07C49/813 ,  C07C45/30 ,  C07C49/784

    摘要： It is desired to find an alternative way to produce benzophenones or substituted benzophenones which does so selectively and avoids the problems of previous methods that use, for example, large amounts of an aluminium chloride catalyst or nitric acid.In the invention process, a diphenyl methane starting material (DPM) in a hydrophobic phase is oxidized in a photolytic process by contact with an aqueous phase containing greater than 1 mole of HBr and at least 1.5 moles of H.sub.2 O.sub.2, both per mole of DPM, the radiation being capable of dissociating bromine to its radicals, and especially using light of wavelength 600 to 250 nm. Preferably, a reaction temperature of around 50.degree. to 65.degree. C., is used, the organic solvent comprising a suitably boiling chlorinated carbon or hydrocarbon. The H.sub.2 O.sub.2 is introduced progressively into the reaction mixture. The benzophenone product is recovered substantially in the organic phase, whereas most of the bromine/bromide is retained in the aqueous phase which can be re-employed in a subsequent oxidation of DPM, possibly after restoration of the bromide to its initial concentration.In a modification to the process, by suitably controlling the mole ratios of bromide and H.sub.2 O.sub.2 to DPM at about 1:1:1, and preferably using a reaction temperature of about ambient to 35.degree. C., the DPM can be substituted by a single bromine atom on the methane carbon also with good selectively, instead of being oxidized to the benzophenone.

    Process for the preparation of 5-nitro-1,4-naphthoquinone
    8.
    发明授权
    Process for the preparation of 5-nitro-1,4-naphthoquinone 失效
    5-硝基-1,4-萘醌的制备方法

    公开(公告)号：US4880571A

    公开(公告)日：1989-11-14

    申请号：US921918

    申请日：1986-10-22

    申请人： Christos Comninellis ,  Robert U. Osterwalder ,  Eric Plattner ,  Gottfried Seifert

    发明人： Christos Comninellis ,  Robert U. Osterwalder ,  Eric Plattner ,  Gottfried Seifert

    IPC分类号： C07B61/00 ,  B01J27/00 ,  C07C67/00 ,  C07C201/00 ,  C07C205/45 ,  C07C205/46 ,  C07C205/48

    CPC分类号： C07C201/12 ,  C07C201/14

    摘要： A process for the preparation of 5-nitro-1,4-naphthoquinones of formula ##STR1## wherein R is hydrogen, a C.sub.1 -C.sub.4 alkyl radical or a C.sub.1 -C.sub.4 alkoxy radical, by oxidation of 1-nitronaphthalene or a suitably substituted 1-nitronaphthalene, which process comprises carrying out the reaction with manganese(III) sulfate as oxidizing agent or a mixture of manganese(III) sulfate and cerium sulfate.The maganese(III) sulfate consumed can be regenerated electrolytically with good current yield. The process is environmentally safe, as the oxidizing agent and the solvent, if any, can be reused.

    摘要翻译： 制备式“IMAGE”的5-硝基-1,4-萘醌的方法，其中R是氢，C1-C4烷基或C1-C4烷氧基，通过1-硝基萘的氧化或适当取代的1-硝基萘 该方法包括用硫酸锰（III）作为氧化剂或硫酸锰（III）和硫酸铈的混合物进行反应。 消耗的硫酸锰（III）可以以较好的电流产率电解再生。 该方法是环境安全的，因为氧化剂和溶剂（如果有的话）可以重复使用。