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公开(公告)号：US20190388588A1
公开(公告)日：2019-12-26
申请号：US16533375
申请日：2019-08-06
发明人： Xuesong Jiang , Sashank Reddy , Gerald Brandacher , Hai-Quan Mao , Justin Sacks , Xiaowei Li , Kevin Feng , Russell Martin , Georgia C. Yalanis , Ji Suk Choi
摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US20180000983A1
公开(公告)日：2018-01-04
申请号：US15545647
申请日：2016-01-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human , The Johns Hopkins University
CPC分类号： A61L24/0031 , A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61L24/001 , A61L24/108 , A61L2400/06
摘要： This disclosure provides novel hydrogels that can undergo multiple gel-sol transitions and methods of making and using such hydrogels, particularly in anastomosis procedures. The peptide hydrogels comprising a fibrillar network of peptides that are in an amphiphilic β-hairpin conformation. The peptides comprise photo-caged glutamate residues with a neutral photocage that can be photolytically selectively uncaged to disrupt the fibrillar network and trigger an irreversible gel-sol phase transition of the hydrogel. Isolated peptides for making the disclosed hydrogels are provided, as are methods of using the peptide hydrogels in anastomosis procedures.
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公开(公告)号：US20230310001A1
公开(公告)日：2023-10-05
申请号：US18013875
申请日：2021-07-07
发明人： Justin Sacks , Helen Xun , Caitlin Hicks , Sung Hoon Kang , Gerald Brandacher , Christopher Shallal
IPC分类号： A61B17/11
CPC分类号： A61B17/1114 , A61B2017/00982 , A61B2017/1107 , A61B2017/1132
摘要： A coupler is provided that includes a member such as a tube having a passageway and at least one end of the tube is inserted into a vessel. Upon insertion, the tube engages with inner walls of the vessel to inhibit movement of the coupler and/or adjoin tissue or a vessel.
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公开(公告)号：US20230293776A1
公开(公告)日：2023-09-21
申请号：US18200526
申请日：2023-05-22
发明人： Xuesong Jiang , Sashank Reddy , Gerald Brandacher , Hai-Quan Mao , Justin Sacks , Xiaowei Li , Kevin Feng , Russell Martin , Georgia C. Yalanis , Ji Suk Choi
CPC分类号： A61L27/52 , A61L27/16 , A61L27/24 , A61L27/3633 , A61L27/56 , A61L27/58 , A61L27/18 , A61L2430/06 , A61L2430/34 , A61L27/48
摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US10086108B2
公开(公告)日：2018-10-02
申请号：US15545647
申请日：2016-01-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Johns Hopkins University
摘要： This disclosure provides novel hydrogels that can undergo multiple gel-sol transitions and methods of making and using such hydrogels, particularly in anastomosis procedures. The peptide hydrogels comprising a fibrillar network of peptides that are in an amphiphilic β-hairpin conformation. The peptides comprise photo-caged glutamate residues with a neutral photocage that can be photolytically selectively uncaged to disrupt the fibrillar network and trigger an irreversible gel-sol phase transition of the hydrogel. Isolated peptides for making the disclosed hydrogels are provided, as are methods of using the peptide hydrogels in anastomosis procedures.
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公开(公告)号：US20230405189A1
公开(公告)日：2023-12-21
申请号：US18210003
申请日：2023-06-14
发明人： Xuesong Jiang , Sashank Reddy , Gerald Brandacher , Hai-Quan Mao , Justin Sacks , Xiaowei Li , Kevin Feng , Russell Martin , Georgia C. Yalanis , Ji Suk Choi
CPC分类号： A61L27/52 , A61L27/16 , A61L27/24 , A61L27/3633 , A61L27/48 , A61L27/58 , A61L27/18 , A61L2430/06 , A61L2430/34 , A61L27/56
摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US11707553B2
公开(公告)日：2023-07-25
申请号：US16533375
申请日：2019-08-06
发明人： Xuesong Jiang , Sashank Reddy , Gerald Brandacher , Hai-Quan Mao , Justin Sacks , Xiaowei Li , Kevin Feng , Russell Martin , Georgia C. Yalanis , Ji Suk Choi
IPC分类号： A61L27/52 , A61L27/16 , A61L27/24 , A61L27/36 , A61L27/56 , A61L27/58 , A61L27/18 , A61L27/48
CPC分类号： A61L27/52 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/3633 , A61L27/56 , A61L27/58 , A61L27/48 , A61L2400/06 , A61L2430/06 , A61L2430/34 , A61L27/16 , C08L5/08 , A61L27/18 , C08L67/04
摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US11684700B2
公开(公告)日：2023-06-27
申请号：US17847832
申请日：2022-06-23
发明人： Xuesong Jiang , Sashank Reddy , Gerald Brandacher , Hai-Quan Mao , Justin Sacks , Xiaowei Li , Kevin Feng , Russell Martin , Georgia C. Yalanis , Ji Suk Choi
IPC分类号： A61L27/52 , A61L27/16 , A61L27/24 , A61L27/36 , A61L27/56 , A61L27/58 , A61L27/18 , A61L27/48
CPC分类号： A61L27/52 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/3633 , A61L27/56 , A61L27/58 , A61L27/48 , A61L2400/06 , A61L2430/06 , A61L2430/34 , A61L27/16 , C08L5/08 , A61L27/18 , C08L67/04
摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US20170095591A1
公开(公告)日：2017-04-06
申请号：US15128257
申请日：2015-04-09
CPC分类号： A61L27/18 , A61L27/26 , A61L27/50 , A61L27/56 , A61L2400/12 , A61L2430/32 , D01D5/003 , D01F8/14 , D10B2509/00 , C08L67/04 , C08L89/06
摘要： The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 μm thick with pores smaller than 25 μm. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.
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公开(公告)号：US10463768B2
公开(公告)日：2019-11-05
申请号：US15432606
申请日：2017-02-14
发明人： Xuesong Jiang , Sashank Reddy , Gerald Brandacher , Hai-Quan Mao , Justin Sacks , Xiaowei Li , Kevin Feng , Russell Martin , Georgia C. Yalanis , Ji Suk Choi
IPC分类号： A61L27/52 , A61L27/16 , A61L27/36 , A61L27/18 , A61L27/56 , A61L27/24 , A61L27/58 , A61L27/48
摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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