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公开(公告)号：US11491151B2
公开(公告)日：2022-11-08
申请号：US17590796
申请日：2022-02-01
发明人： Kelly Lee Martin Schmeichel , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines , Thomas Edward Huetter , Radhika R. Iyer , Daren K. Anness
IPC分类号： A61K31/485 , A61K31/137 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K9/00 , A61K9/08 , A61J1/05 , A61K31/167 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26
摘要： A stable liquid composition contained in a bottle wherein the composition comprises from about 0.001% to about 0.5% of phenylephrine hydrochloride, by weight of the stable liquid composition. The composition comprises less than about 0.1% of total aldehydes, by weight of the stable liquid composition, and has a pH from about 2 to about 6.5. The bottle comprises a material selected from polyethylene terephthalate (PET), glycol-modified polyethylene terephthalate (PETG), oriented polypropylene (OPP), polyvinylchloride (PVC), polyvinylidene chloride (PVDC), nylon, polyethylene terephthalate polyester (PETP), or combinations thereof.
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公开(公告)号：US20220023236A1
公开(公告)日：2022-01-27
申请号：US17498152
申请日：2021-10-11
发明人： Kelly Lee Martin Schmeichel , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines , Thomas Edward Huetter , Radhika R. Iyer , Daren K. Anness
IPC分类号： A61K31/137 , A61K9/00 , A61K47/26
摘要： A stable liquid composition in a clear bottle wherein the composition comprises from about 0.001% to about 0.5% of phenylephrine hydrochloride, by weight of the stable liquid composition. The composition comprises less than about 0.1% of total aldehydes, by weight of the stable liquid composition, and has a pH from about 2 to about 6.5. The clear bottle comprises a material selected from polyethylene terephthalate (PET), glycol-modified polyethylene terephthalate (PETG), oriented polypropylene (OPP), polyvinylchloride (PVC), polyvinylidene chloride (PVDC), nylon, polyethylene terephthalate polyester (PETP), polyphene, or combinations thereof.
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公开(公告)号：US20200268746A1
公开(公告)日：2020-08-27
申请号：US15930540
申请日：2020-05-13
发明人： Kelly Lee Martin Schmeichel , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines , Thomas Edward Huetter , Radhika R. Iyer , Daren K. Anness
IPC分类号： A61K31/485 , A61K31/137 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K9/00 , A61K9/08 , A61J1/05 , A61K31/167 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26
摘要： A stable liquid composition in a clear bottle where the composition contains, at least, phenylephrine and acetaminophen. The composition is substantially free of aldehydes and has a pH from 3.5 to 5. The clear bottle is a polyethylene terphthalate bottle.
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公开(公告)号：US20180360780A1
公开(公告)日：2018-12-20
申请号：US16109830
申请日：2018-08-23
发明人： Kelly Lee Schmeichel , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines
IPC分类号： A61K31/137 , A61K31/55 , A61K31/495 , A61K45/06 , A61K31/473 , A61K31/522 , A61K31/519 , A61K31/485 , A61K31/616
摘要： Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the
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公开(公告)号：US12083117B2
公开(公告)日：2024-09-10
申请号：US17498152
申请日：2021-10-11
发明人： Kelly Lee Martin Schmeichel , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines , Thomas Edward Huetter , Radhika R. Iyer , Daren K. Anness
IPC分类号： A61K31/485 , A61J1/05 , A61K9/00 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0095 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26 , A61K31/137 , A61K2300/00 , A61K31/473 , A61K2300/00 , A61K31/485 , A61K2300/00 , A61K31/495 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/522 , A61K2300/00 , A61K31/55 , A61K2300/00 , A61K31/616 , A61K2300/00
摘要： A stable liquid composition in a clear bottle wherein the composition comprises from about 0.001% to about 0.5% of phenylephrine hydrochloride, by weight of the stable liquid composition. The composition comprises less than about 0.1% of total aldehydes, by weight of the stable liquid composition, and has a pH from about 2 to about 6.5. The clear bottle comprises a material selected from polyethylene terephthalate (PET), glycol-modified polyethylene terephthalate (PETG), oriented polypropylene (OPP), polyvinylchloride (PVC), polyvinylidene chloride (PVDC), nylon, polyethylene terephthalate polyester (PETP), polyphene, or combinations thereof.
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公开(公告)号：US20220265531A1
公开(公告)日：2022-08-25
申请号：US17577402
申请日：2022-01-18
发明人： Lawrence Edward Dolan , Steven Hamilton Hoke, III , Sanjeev Midha , Jonathan M. Pahren , Niranjan Ramji , Rachel Anne Trenner
IPC分类号： A61K8/22 , A61Q11/00 , A61K8/81 , A61K8/19 , A61K8/24 , A61K8/44 , A61K8/49 , A61K8/21 , A61K8/27 , A61K8/46
摘要： Oral care compositions including peroxide and abrasive. Dentifrice compositions including peroxide and abrasive. Oral care compositions including peroxide and calcium pyrophosphate. Dentifrice compositions including peroxide and calcium pyrophosphate. Dentifrice compositions including peroxide and calcium pyrophosphate with a gamma phase to beta phase ratio of at least about 0.8. Dentifrice composition including peroxide and calcium pyrophosphate with a gamma phase to beta phase ratio of at least about 1. Methods of use of the disclosed compositions to whiten teeth.
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公开(公告)号：US11191709B2
公开(公告)日：2021-12-07
申请号：US16850051
申请日：2020-04-16
摘要： A mouth rinse composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. A dentifrice composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. The cationic antimicrobial agent is a quaternary ammonium salt, such as cetyl pyridinium chloride, or a metal ion source, such as stannous fluoride.
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公开(公告)号：US20200337972A1
公开(公告)日：2020-10-29
申请号：US16850051
申请日：2020-04-16
摘要： A mouth rinse composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. A dentifrice composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. The cationic antimicrobial agent is a quaternary ammonium salt, such as cetyl pyridinium chloride, or a metal ion source, such as stannous fluoride.
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公开(公告)号：US10772848B2
公开(公告)日：2020-09-15
申请号：US16109823
申请日：2018-08-23
发明人： Kelly Lee Schmeichel , Jayant Eknath Khanolkar , Douglas William Gledhill , Susan Elaine Criss , Niranjan Ramji , Elaine Rose Costeines
IPC分类号： A61K31/137 , A61K31/473 , A61K31/485 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06
摘要： Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the composition has a pH of from about 2 to about 5 and is substantially free of aldehydes.
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公开(公告)号：US20220257484A1
公开(公告)日：2022-08-18
申请号：US17728246
申请日：2022-04-25
发明人： Niranjan Ramji , Ann Gilligan Snider , Lina Aurora Witte , Beverly D. Becker , Beth Hansell Statt , Andrea L. Noland , Kristi McKinney
摘要： Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure wherein R1, R2, R3, and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, —OH or —ORa; R4 is —OH, —ORa, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and Ra is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from α-damascenone, α-isomethylionone, α-ionone, β-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde.
The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.
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