公开(公告)号：US11877846B2

公开(公告)日：2024-01-23

申请号：US18313168

申请日：2023-05-05

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/0022 ,  A61B5/685 ,  A61B2562/046 ,  A61B2562/125

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US20220178867A1

公开(公告)日：2022-06-09

申请号：US17438356

申请日：2020-03-12

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Farshad Tehrani ,  Eva Vargas Orgaz ,  Hazhir Teymourian ,  Eyal Dassau

IPC: G01N27/327 ,  C12Q1/26 ,  C12Q1/00 ,  G01N33/49

Abstract: Disclosed are devices, systems and methods for monitoring one or more biomarkers using an electrochemical immunosensor sensor with an integrated enzymatic and immunosensing electrochemical detection capability. In some aspects, an electrochemical sensor device for monitoring glucose and insulin includes a substrate; and a plurality of electrodes disposed on the substrate, the plurality of electrodes including a first electrode to sense glucose, a second electrode to sense insulin, and a counter electrode to the first and second electrodes, in which the first electrode includes a glucose oxidase enzyme linked to a surface of the first electrode, and the second electrode includes an insulin capture antibody linked to a second electrode through a self-assembly monolayer, and in which, when the device is electrically coupled to an electronics unit, the device is operable to detect insulin and glucose from a fluid.

公开(公告)号：US20230320636A1

公开(公告)日：2023-10-12

申请号：US18313168

申请日：2023-05-05

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/0022 ,  A61B5/685 ,  A61B2562/046 ,  A61B2562/125

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US11684298B2

公开(公告)日：2023-06-27

申请号：US17860070

申请日：2022-07-07

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/0022 ,  A61B5/685 ,  A61B2562/046 ,  A61B2562/125

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US20250114020A1

公开(公告)日：2025-04-10

申请号：US18984998

申请日：2024-12-17

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US20240180459A1

公开(公告)日：2024-06-06

申请号：US18407265

申请日：2024-01-08

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/0022 ,  A61B5/685 ,  A61B2562/046 ,  A61B2562/125

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US20230012662A1

公开(公告)日：2023-01-19

申请号：US17860070

申请日：2022-07-07

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US12171555B2

公开(公告)日：2024-12-24

申请号：US18407265

申请日：2024-01-08

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.