公开(公告)号：US11130788B2

公开(公告)日：2021-09-28

申请号：US16412133

申请日：2019-05-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

发明人： Andrew R. Hagen ,  Cheryl A. Kerfeld ,  Nancy B. Sloan ,  Markus Sutter ,  Bryan H. Ferlez

IPC分类号： C07K1/00 ,  C07K14/195 ,  C12N15/62 ,  C07K1/22 ,  B01D15/36 ,  B01D15/38 ,  C07K14/315

摘要： The present invention provides for a fusion protein comprising (1) a bacterial microcompartment (BMC) shell protein comprising one or more subunit, and (2) a first component of a specific-binding pair, operably linked to the BMC shell protein such that the first component faces (i) a lumen (inside) side, or (ii) outside of a BMC shell formed incorporating the fusion protein and the fusion protein does not disrupt or prevent the folding of the BMC shell protein or the ability of the BMC shell protein to integrate with other BMC shell proteins into a BMC shell; wherein the first component is capable of forming a stable or irreversible interaction with a second component of the specific-binding pair.

公开(公告)号：US12071455B2

公开(公告)日：2024-08-27

申请号：US17458131

申请日：2021-08-26

申请人： The Regents of the University of California ,  BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

发明人： Andrew R. Hagen ,  Cheryl A. Kerfeld ,  Nancy B. Sloan ,  Markus Sutter ,  Bryan H. Ferlez

IPC分类号： C07K14/195 ,  B01D15/36 ,  B01D15/38 ,  C07K1/22 ,  C07K14/315 ,  C12N15/62

CPC分类号： C07K14/195 ,  B01D15/363 ,  B01D15/3804 ,  C07K1/22 ,  C07K14/315 ,  C12N15/62 ,  C07K2319/70

摘要： The present invention provides for a fusion protein comprising (1) a bacterial microcompartment (BMC) shell protein comprising one or more subunit, and (2) a first component of a specific-binding pair, operably linked to the BMC shell protein such that the first component faces (i) a lumen (inside) side, or (ii) outside of a BMC shell formed incorporating the fusion protein and the fusion protein does not disrupt or prevent the folding of the BMC shell protein or the ability of the BMC shell protein to integrate with other BMC shell proteins into a BMC shell; wherein the first component is capable of forming a stable or irreversible interaction with a second component of the specific-binding pair.

公开(公告)号：US20210395314A1

公开(公告)日：2021-12-23

申请号：US17458131

申请日：2021-08-26

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

发明人： Andrew R. Hagen ,  Cheryl A. Kerfeld ,  Nancy B. Sloan ,  Markus Sutter ,  Bryan H. Ferlez

IPC分类号： C07K14/195 ,  C12N15/62 ,  C07K1/22 ,  B01D15/36 ,  B01D15/38 ,  C07K14/315

摘要： The present invention provides for a fusion protein comprising (1) a bacterial microcompartment (BMC) shell protein comprising one or more subunit, and (2) a first component of a specific-binding pair, operably linked to the BMC shell protein such that the first component faces (i) a lumen (inside) side, or (ii) outside of a BMC shell formed incorporating the fusion protein and the fusion protein does not disrupt or prevent the folding of the BMC shell protein or the ability of the BMC shell protein to integrate with other BMC shell proteins into a BMC shell; wherein the first component is capable of forming a stable or irreversible interaction with a second component of the specific-binding pair.