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1.发明申请TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION 审中-公开复合化合物与氟化物反应的目标，金属催化的氟化反应公开(公告)号：US20160158388A1
公开(公告)日：2016-06-09
申请号：US15019673
申请日：2016-02-09
发明人： John T. Groves , Xiongyi Huang
IPC分类号： A61K51/04 , C07C22/08 , C07C43/29 , C07C41/22 , B01J31/18 , C07C49/80 , C07C45/63 , C07D209/48 , C07D213/643 , C07C17/06 , C07D319/20
摘要： Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
摘要翻译： 本文包含使用氟化物通过羧基氟化制备氟化合物的方法。 提供氟化合物。 本文包含使用氟化化合物的方法。
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2.发明授权公开(公告)号：US10974235B2
公开(公告)日：2021-04-13
申请号：US16702014
申请日：2019-12-03
发明人： John T. Groves , Xiongyi Huang
IPC分类号： C07B59/00 , C07D213/643 , B01J31/18 , A61K51/04 , C07C41/22 , C07D319/20 , C07C49/80 , C07D209/48 , C07C69/65 , B01J31/22 , C07C67/287 , B01J31/02 , B01J31/04 , C07J1/00 , C07B39/00 , C07C17/363 , C07C45/67 , C07C49/813 , C07C43/225
摘要： Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
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3.发明申请公开(公告)号：US20180037526A1
公开(公告)日：2018-02-08
申请号：US15549040
申请日：2016-02-09
发明人： John T. Groves , Xiongyi Huang
CPC分类号： C07C17/363 , B01J31/22 , B01J31/32 , C07B39/00 , C07B2200/05 , C07C22/08 , C07C23/46 , C07C41/22 , C07C45/676 , C07C67/297 , C07C253/30 , C07C255/35 , C07C2601/14 , C07C2603/74 , C07D209/46 , C07D209/48 , C07D319/20 , C07D333/12 , C07D493/18 , C07J1/0059 , C07C22/00 , C07C43/225 , C07C49/813 , C07C69/65
摘要： Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
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4.发明授权公开(公告)号：US10543481B2
公开(公告)日：2020-01-28
申请号：US15019673
申请日：2016-02-09
发明人： John T. Groves , Xiongyi Huang
IPC分类号： B01J31/18 , C07C49/80 , C07D319/20 , A61K51/04 , C07C41/22 , C07D209/48 , C07D213/643
摘要： Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
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公开(公告)号：US20160264512A1
公开(公告)日：2016-09-15
申请号：US15028310
申请日：2014-10-09
发明人： John T. Groves , Wei Liu , Xiongyi Huang
IPC分类号： C07C69/65 , C07B59/00 , A61K51/04 , A61K31/137 , A61K31/198 , C07C311/09 , C07C233/14 , C07C49/255 , C07C49/813 , C07D231/12 , C07D217/20 , C07D207/16 , C07C233/18 , C07C271/16 , C07C271/14 , C07B39/00
CPC分类号： C07C69/65 , A61K31/137 , A61K31/198 , A61K51/0402 , C07B39/00 , C07B59/001 , C07B2200/05 , C07C22/08 , C07C25/13 , C07C49/255 , C07C49/697 , C07C49/755 , C07C49/813 , C07C69/63 , C07C233/07 , C07C233/14 , C07C233/18 , C07C255/10 , C07C271/14 , C07C271/16 , C07C311/09 , C07C2602/08 , C07C2602/10 , C07C2603/32 , C07D207/16 , C07D209/48 , C07D215/06 , C07D215/18 , C07D217/20 , C07D231/12 , C07D333/54 , Y02P20/582
摘要： Fluorinated compounds are provided. Fluorinated compounds may be prepared by a method of halogenating a carbon containing compound having an sp3 C—H bond.
摘要翻译： 提供氟化合物。 氟化化合物可以通过卤化具有sp 3 C-H键的含碳化合物的方法来制备。
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公开(公告)号：US20150031768A1
公开(公告)日：2015-01-29
申请号：US14510509
申请日：2014-10-09
发明人： John T. Groves , Wei Liu , Xiongyi Huang
IPC分类号： C07C211/42 , A61K31/198 , A61K31/192 , A61K31/135 , C07C57/30
CPC分类号： A61K31/198 , A61K31/135 , A61K31/192 , C07B39/00 , C07B2200/05 , C07C17/10 , C07C22/08 , C07C25/13 , C07C231/12 , C07C233/14 , C07C233/18 , C07C253/30 , C07C255/35 , C07C271/14 , C07C303/40 , C07C311/09 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/18 , C07C2602/42 , C07C2603/32 , C07C2603/74 , C07D209/48 , C07D215/18 , C07D217/20 , C07D231/12 , C07D333/28 , C07D333/54 , C07J11/00 , C07J63/008 , Y02P20/582 , C07C23/16 , C07C23/10 , C07C23/28 , C07C23/14 , C07C23/46
摘要： Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.
摘要翻译： 提供了具有sp 3 C-H键的含碳化合物的卤化方法。 提供了用Cl或Br氟化包含卤化的含碳化合物，然后用F进行亲核取代的方法。 提供了具有sp 3 C-H键的含碳化合物的直接氧化C-H氟化方法。 提供了这些方法的卤化产物。
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