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公开(公告)号：US20180223251A1
公开(公告)日：2018-08-09
申请号：US15748066
申请日：2016-07-27
发明人： Dongeun Huh , Mark Mondrinos , Cassidy Blundell , Jeongyun Seo
IPC分类号： C12N5/00 , A61L27/22 , A61L27/18 , A61L27/38 , C12M3/00 , C12M1/00 , C12M1/12 , A61L27/52 , C08L83/04
CPC分类号： C12N5/0068 , A61L27/18 , A61L27/22 , A61L27/3633 , A61L27/3804 , A61L27/52 , C08L83/04 , C12M3/00 , C12M21/08 , C12M23/20 , C12M25/14 , C12M29/10 , C12N5/0018 , C12N5/0062 , C12N2533/30 , C12N2533/54 , C12N2535/00 , C12N2537/10
摘要： The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spatial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.
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公开(公告)号：US20180216058A1
公开(公告)日：2018-08-02
申请号：US15748039
申请日：2016-07-27
发明人： Dongeun Huh , Mark Mondrinos , Woo Yul Byun
CPC分类号： C12M21/08 , A61L27/18 , A61L27/3804 , A61L27/50 , A61L27/52 , C12M23/16 , C12M23/20 , C12M25/02 , C12M25/14 , G01N33/5044 , C08L83/04
摘要： The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
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公开(公告)号：US11453848B2
公开(公告)日：2022-09-27
申请号：US15748087
申请日：2016-07-27
发明人： Dongeun Huh , Mark Mondrinos
IPC分类号： G01N33/50 , C12M3/00 , C12M1/00 , C12M1/12 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/50 , A61L27/22 , A61L27/36 , C08L83/04 , C12N5/00 , G09B23/30 , C12M3/06
摘要： The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
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公开(公告)号：US20210348095A1
公开(公告)日：2021-11-11
申请号：US17232588
申请日：2021-04-16
发明人： Dongeun Huh , Mark Mondrinos , Cassidy Blundell , Jeongyun Seo
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/50 , A61L27/22 , A61L27/36 , C08L83/04 , C12N5/00 , G01N33/50 , C12M3/06
摘要： The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.
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公开(公告)号：US20240218306A1
公开(公告)日：2024-07-04
申请号：US18484728
申请日：2023-10-11
发明人： Dongeun Huh , Mark Mondrinos , Woo Yul Byun
IPC分类号： C12M3/00 , A61L27/18 , A61L27/22 , A61L27/36 , A61L27/38 , A61L27/50 , A61L27/52 , C08L83/04 , C12M1/00 , C12M1/12 , C12M3/06 , C12N5/00 , G01N33/50 , G09B23/30
CPC分类号： C12M21/08 , A61L27/18 , A61L27/22 , A61L27/3633 , A61L27/3804 , A61L27/50 , A61L27/52 , C08L83/04 , C12M3/00 , C12M23/16 , C12M23/20 , C12M25/02 , C12M25/14 , C12M29/10 , C12N5/0018 , C12N5/0062 , C12N5/0068 , G01N33/5005 , G01N33/5044 , G09B23/30 , G09B23/306 , C12N2533/30 , C12N2533/54 , C12N2535/00 , C12N2537/10
摘要： The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
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公开(公告)号：US20230151316A1
公开(公告)日：2023-05-18
申请号：US17814948
申请日：2022-07-26
发明人： Dongeun Huh , Mark Mondrinos
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/50 , A61L27/22 , A61L27/36 , C08L83/04 , C12N5/00 , G01N33/50 , G09B23/30 , C12M3/06
CPC分类号： C12M21/08 , C12M23/20 , C12M25/14 , A61L27/18 , A61L27/3804 , A61L27/52 , A61L27/50 , A61L27/22 , A61L27/3633 , C08L83/04 , C12M3/00 , C12M29/10 , C12N5/0018 , C12N5/0062 , C12N5/0068 , G01N33/5005 , G09B23/30 , G09B23/306 , C12M25/02 , G01N33/5044 , C12M23/16 , C12N2533/30 , C12N2533/54 , C12N2535/00 , C12N2537/10
摘要： The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
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公开(公告)号：US20180230415A1
公开(公告)日：2018-08-16
申请号：US15748087
申请日：2016-07-27
发明人： Dongeun Huh , Mark Mondrinos
CPC分类号： C12M21/08 , A61L27/18 , A61L27/3804 , A61L27/50 , A61L27/52 , C12M23/16 , C12M23/20 , C12M25/02 , C12M25/14 , G01N33/5044 , C08L83/04
摘要： The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
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公开(公告)号：US11946028B2
公开(公告)日：2024-04-02
申请号：US17814948
申请日：2022-07-26
发明人： Dongeun Huh , Mark Mondrinos
IPC分类号： C12M3/00 , A61L27/18 , A61L27/22 , A61L27/36 , A61L27/38 , A61L27/50 , A61L27/52 , C08L83/04 , C12M1/00 , C12M1/12 , C12N5/00 , G01N33/50 , G09B23/30
CPC分类号： C12M21/08 , A61L27/18 , A61L27/22 , A61L27/3633 , A61L27/3804 , A61L27/50 , A61L27/52 , C08L83/04 , C12M3/00 , C12M23/00 , C12M23/20 , C12M25/02 , C12M25/14 , C12M29/10 , C12N5/0018 , C12N5/0062 , C12N5/0068 , G01N33/5005 , G01N33/5044 , G09B23/30 , G09B23/306 , C12N2533/30 , C12N2533/54 , C12N2535/00 , C12N2537/10 , A61L27/18 , C08L83/04
摘要： The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.
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公开(公告)号：US11814613B2
公开(公告)日：2023-11-14
申请号：US15748039
申请日：2016-07-27
发明人： Dongeun Huh , Mark Mondrinos , Woo Yul Byun
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/50 , A61L27/22 , A61L27/36 , C08L83/04 , C12N5/00 , G01N33/50 , G09B23/30 , C12M3/06
CPC分类号： C12M21/08 , A61L27/18 , A61L27/22 , A61L27/3633 , A61L27/3804 , A61L27/50 , A61L27/52 , C08L83/04 , C12M3/00 , C12M23/16 , C12M23/20 , C12M25/02 , C12M25/14 , C12M29/10 , C12N5/0018 , C12N5/0062 , C12N5/0068 , G01N33/5005 , G01N33/5044 , G09B23/30 , G09B23/306 , C12N2533/30 , C12N2533/54 , C12N2535/00 , C12N2537/10 , A61L27/18 , C08L83/04
摘要： The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
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公开(公告)号：US11008546B2
公开(公告)日：2021-05-18
申请号：US15748066
申请日：2016-07-27
发明人： Dongeun Huh , Mark Mondrinos , Cassidy Blundell , Jeongyun Seo
IPC分类号： C12N5/00 , A61L27/22 , A61L27/18 , A61L27/38 , C12M3/00 , C12M1/00 , C12M1/12 , A61L27/52 , C08L83/04 , A61L27/36
摘要： The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.
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