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公开(公告)号：US12039885B2
公开(公告)日：2024-07-16
申请号：US16778947
申请日：2020-01-31
CPC分类号： G09B23/306 , C12N5/069 , G09B23/303 , G09B23/32
摘要： A venous valve model includes a first layer having a central axis and a fluid channel extending between a fluid inlet and a fluid outlet formed in the first layer, wherein the fluid channel is defined by a pair of channel walls, a first venous valve formed in the first layer and positioned along the fluid channel, and a pair of first actuation chambers positioned adjacent the channel walls of the fluid channel, wherein the pair of first actuation chambers are configured to decrease a width of the fluid channel in response to pressurization of the pair of first actuation chambers.
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公开(公告)号：US20240074899A1
公开(公告)日：2024-03-07
申请号：US18376927
申请日：2023-10-05
发明人： Yang Hu
CPC分类号： A61F9/00781 , G09B23/306
摘要： Injection of silicon oil (SO) to the anterior chamber of an eye efficiently induces intraocular pressure (TOP) elevation. This effect occurs without causing overt ocular structural damage or inflammatory responses while simulating acute glaucomatous changes that human patients develop over years by inducing progressive RGC and ON degeneration and visual functional deficits within weeks. The anterior segments of the experimental eyes are not substantially affected, leaving clear ocular elements that allow easy and reliable assessment of in vivo visual function and morphology. More importantly, this is the only reversible ocular hypertension model by removing SO from the anterior chamber and particularly useful for testing neuroprotection treatment together with lowering TOP treatment. In summary, the acute ocular hypertension glaucoma model replicates secondary post-operative glaucoma. It is straightforward and reversible, does not require special equipment or repeat injections, and may be applicable to a range of animal species with only minor modifications.
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公开(公告)号：US11915610B2
公开(公告)日：2024-02-27
申请号：US16875530
申请日：2020-05-15
发明人： Joss Dean Fernandez
CPC分类号： G09B23/303 , A01N1/02 , G09B23/306
摘要： A cadaverous heart model and methods of making and using the cadaverous heart model are provided. The cadaverous heart model may remain within the chest cavity of the cadaver (in situ) or may be explanted (ex vivo). The efferent and afferent vessels of the heart are ligated and one or more of the heart chambers are cannulated to permit the infusion of fluid. Video cameras or other means for visualizing the flow of fluid and opening and closing of valves are applied internally or proximally externally. Pumps and inflatable bladders are used to effect the flow of fluid within the heart model.
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公开(公告)号：US11735066B2
公开(公告)日：2023-08-22
申请号：US17560553
申请日：2021-12-23
发明人： Gianfranco Beniamino Fiore , Alberto Cesare Luigi Redaelli , Riccardo Vismara , Carlo Antona , Guido Gelpi , Massimo Giovanni Lemma , Andrea Mangini
CPC分类号： G09B23/303 , A01N1/0247 , G09B23/30 , G09B23/306 , A61B2017/00716
摘要： A test bench assembly for simulating cardiac surgery includes a passive heart having at least one pair of cardiac chambers with an atrial chamber and a ventricular chamber. A reservoir is adapted to house working fluid. A pressure generator fluidically connects both to the ventricular chamber of the passive heart and to the reservoir. A pressure regulation device provides working fluid in input to the atrial chamber with preload pressure, and working fluid in output from the ventricular chamber with afterload pressure. The pressure regulation device fluidically connects both to the atrial chamber of the passive heart and to the ventricular chamber of the passive heart. The pressure regulation device has a single compliant element for each pair of cardiac chambers, which provides working fluid with both preload, and afterload pressures.
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公开(公告)号：US11645951B2
公开(公告)日：2023-05-09
申请号：US17253347
申请日：2019-04-01
申请人： EBM CORPORATION
发明人： Young-Kwang Park , Manabu Shinke , Masaaki Ito
CPC分类号： G09B23/34 , B29C65/48 , B29C66/45 , B29C66/729 , G09B23/306 , B29L2031/40
摘要： [Problem to be Solved by the Invention]
To provide an artificial tissue model that can be more advantageously used in surgical technique training compared to previous artificial tissues, as well as a method of fabricating the same.
[Solution]
An artificial organ model for surgical technique training comprising two or more fibrous layers 2, 3 layered and bonded to each other so as to be peelable by a surgical technique performed by a surgical technique trainee; the layered and bonded two or more fibrous layers 2, 3 as a whole being saturated with an electroconductive liquid or gel; and two adjacent fibrous layers out of the two or more fibrous layers being formed from different materials or substances or in different colors so as to be recognizable as different membranes by the surgical technique trainee.-
公开(公告)号：US20180207264A1
公开(公告)日：2018-07-26
申请号：US15875606
申请日：2018-01-19
发明人： Thomas Shaak , Suizhao Wang , Joseph Harre
IPC分类号： A61K39/39 , A61K31/568 , A61K31/573 , A61K9/00 , A61K9/127
CPC分类号： A61K9/1271 , A61B10/02 , A61B17/32053 , A61B2017/00707 , A61K9/0019 , A61K31/565 , A61K31/568 , A61K31/573 , A61K39/39 , A61K47/10 , A61K47/24 , A61K2300/00 , A61M1/0088 , A61P35/00 , G09B23/306 , G09B23/34
摘要： A method of modulating an immune response. The method includes administering a treatment comprising delta 5-androsten-3B, 17B-diol, delta 5-androsten-3B, 7B, 17B-triol, or both.
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公开(公告)号：US20180055570A1
公开(公告)日：2018-03-01
申请号：US15682733
申请日：2017-08-22
申请人： Virtamed AG
发明人： Carolyn O'BRIEN , Kelly WETTENGEL
CPC分类号： A61B34/10 , G09B23/285 , G09B23/30 , G09B23/306 , G09B23/34
摘要： Anatomy mannequins, models and medical simulation systems described herein may facilitate various medical procedure training by rendering a realistic passive haptic touch when the end user manipulates the anatomy model with a handheld tool. An anatomy tissue model may comprise at least one fabric layer arranged over at least one foam layer to replicate the low-friction, elasticity and hardness of a living body anatomy tissue, such as the vagina wall, without requiring the use of lubricant in the medical simulation training procedure. The anatomy tissue model may be attached as an insert to a body structure model. A diversity of anatomy tissue models may be adapted with different fabric layer and/or foam layer designs, each design corresponding to a different haptic touch, so they can be interchanged in a medical training simulator system to realistically replicate different medical training scenarios.
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公开(公告)号：US20170263158A1
公开(公告)日：2017-09-14
申请号：US15608652
申请日：2017-05-30
CPC分类号： G09B23/285 , A61B5/4566 , A61B17/1671 , B29C45/14795 , G09B23/28 , G09B23/30 , G09B23/306 , G09B23/34
摘要： A model for anatomical training includes a clear thermoplastic elastomer matrix formed with at least one contoured surface that simulates at least a portion of a human body. The visibly clear thermoplastic elastomer matrix provides visible needle tracks upon needle penetration that may be fused closed upon heating the thermoplastic elastomer matrix. The model includes at least a portion of a vertebral column with a synthetic spinal sheath passing through a portion of the vertebral column, the synthetic spinal sheath providing tactile feedback upon needle penetration that simulates the tactile feedback of a needle penetrating a natural human spinal sheath.
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公开(公告)号：US20170238533A1
公开(公告)日：2017-08-24
申请号：US15592343
申请日：2017-05-11
申请人： Medtronic, Inc.
CPC分类号： A01N1/0247 , G09B23/303 , G09B23/306
摘要： An isolated heart or heart-lung preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, ablation methods, cardiac implants and other medical devices intended to be used in or on a beating heart. The system can be designed to be used within a Magnetic Resonance Imaging (MRI) unit or a X-ray computed tomography (CT) scanner. The preparation may also be employed to investigate heart and lung functions, in the presence or absence of such medical devices. In order to allow comparative imaging visualizations of either or simultaneously the heart and/or lung structures and devices located within the chambers of the heart or vessels or bronchi within the lungs, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and thus the coronary and/or pulmonary vasculatures. A ventilator with intubation tube can be used to inflate/deflate the lungs and/or provide oxygen to the isolated organs. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart and/or lungs, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the cardiopulmonary system.
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公开(公告)号：US20160329000A1
公开(公告)日：2016-11-10
申请号：US15148317
申请日：2016-05-06
IPC分类号： G09B23/30
CPC分类号： G09B23/306 , G09B19/00 , G09B23/30 , G09B23/303
摘要： This invention is directed to a modular staged simulator and a process of simulating medical trauma and maladies for the purpose of training or certifying individuals including medical professionals. More specifically, this disclosure relates to ex vivo training exercises as opposed to traditional forms of training using intact cadavers, in vivo surgery on animal subjects; and supervised apprenticeship performing surgery on human subjects with trauma or maladies under the watch of a skilled medical practitioner.
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