公开(公告)号：US11646099B2

公开(公告)日：2023-05-09

申请号：US16713528

申请日：2019-12-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Mayo Foundation for Medical Education and Research ,  Julius-Maximilians-University of Würzburg ,  Board of Regents of the University of Nebraska ,  Oslo University Hospital HF ,  Hospital Clinic de Barcelona ,  Universitat de Barcelona ,  Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) ,  Robert Bosch Gesellschaft fuer medizinische Forschung mbH ,  Oregon Health & Science University ,  City of Hope ,  The Cleveland Clinic Foundation

发明人： Louis M. Staudt ,  Christian Steidl ,  Anja Mottok ,  George W. Wright ,  David William Scott ,  Lisa M. Rimsza ,  Andreas Rosenwald ,  Randy Gascoyne ,  Timothy Greiner ,  Dennis Weisenburger ,  Erlend B. Smeland ,  Jan Delabie ,  Elias Campo Guerri ,  German Ott ,  Rita Braziel ,  Elaine S. Jaffe ,  Kai Fu ,  Wing C. Chan ,  Joo Song ,  James R. Cook

IPC分类号： G01N33/48 ,  G16B5/00 ,  G16B25/10 ,  C12Q1/6886

CPC分类号： G16B5/00 ,  C12Q1/6886 ,  G16B25/10 ,  C12Q2600/112 ,  C12Q2600/158

摘要： In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.

公开(公告)号：US11725248B2

公开(公告)日：2023-08-15

申请号：US16094965

申请日：2017-04-20

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Julius-Maximilians—University of Würzburg ,  Oregon Health & Science University ,  Hospital Clinic de Barcelona ,  Universitat de Barcelona ,  Oslo University Hospital HF ,  Board of Regents of the University of Nebraska ,  The Cleveland Clinic Foundation ,  Mayo Foundation for Medical Education and Research

发明人： Louis M. Staudt ,  David William Scott ,  George W. Wright ,  Andreas Rosenwald ,  Pau Abrisqueta ,  Rita Braziel ,  Elias Campo Guerri ,  Wing C. Chan ,  Joseph M. Connors ,  Jan Delabie ,  Diego Villa ,  Kai Fu ,  Randy D. Gascoyne ,  Timothy Greiner ,  Elaine S. Jaffe ,  Pedro Jares ,  Anja Mottok ,  German Ott ,  Lisa M. Rimsza ,  Graham Slack ,  Dennis Weisenburger ,  Erlend B. Smeland ,  James Robert Cook

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.

公开(公告)号：US20190153539A1

公开(公告)日：2019-05-23

申请号：US16094965

申请日：2017-04-20

申请人： The United States of America, as represented by the secretary, Dep. of Health and Human Service ,  British Columbia Cancer Agency Branch ,  Julius-Maximilians - University of Würzburg ,  Oregon Health & Science University ,  Hospital Clinic de Barcelona ,  Universitat de Barcelona ,  Oslo University Hospital HF ,  Board of Regents of the University of Nebraska ,  The Cleveland Clinic Foundation ,  Mayo Foundation for Medical Education and Research

发明人： Louis M. Staudt ,  David William Scott ,  George W. Wright ,  Andreas Rosenwald ,  Pau Abrisqueta ,  Rita Braziel ,  Elias Campo Guerri ,  Wing C. Chan ,  Joseph M. Connors ,  Jan Delabie ,  Diego Villa ,  Kai Fu ,  Randy D. Gascoyne ,  Timothy Greiner ,  Elaine S. Jaffe ,  Pedro Jares ,  Anja Mottok ,  German Ott ,  Lisa M. Rimsza ,  Graham Slack ,  Dennis Weisenburger ,  Erlend B. Smeland ,  James Robert Cook

IPC分类号： C12Q1/6886

摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.