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公开(公告)号：US11646099B2
公开(公告)日：2023-05-09
申请号：US16713528
申请日：2019-12-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Mayo Foundation for Medical Education and Research , Julius-Maximilians-University of Würzburg , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Hospital Clinic de Barcelona , Universitat de Barcelona , Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) , Robert Bosch Gesellschaft fuer medizinische Forschung mbH , Oregon Health & Science University , City of Hope , The Cleveland Clinic Foundation
发明人： Louis M. Staudt , Christian Steidl , Anja Mottok , George W. Wright , David William Scott , Lisa M. Rimsza , Andreas Rosenwald , Randy Gascoyne , Timothy Greiner , Dennis Weisenburger , Erlend B. Smeland , Jan Delabie , Elias Campo Guerri , German Ott , Rita Braziel , Elaine S. Jaffe , Kai Fu , Wing C. Chan , Joo Song , James R. Cook
IPC分类号： G01N33/48 , G16B5/00 , G16B25/10 , C12Q1/6886
CPC分类号： G16B5/00 , C12Q1/6886 , G16B25/10 , C12Q2600/112 , C12Q2600/158
摘要： In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.
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公开(公告)号：US11725248B2
公开(公告)日：2023-08-15
申请号：US16094965
申请日：2017-04-20
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Julius-Maximilians—University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
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公开(公告)号：US11574704B2
公开(公告)日：2023-02-07
申请号：US16746347
申请日：2020-01-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Hospital Clinic de Barcelona , The Cleveland Clinic Foundation , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians—University of Würzburg , Oslo University Hospital HF
发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger
IPC分类号： G01N33/48 , G16B25/10 , G16B25/00 , G16B5/00 , C12Q1/6886
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
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公开(公告)号：US10607717B2
公开(公告)日：2020-03-31
申请号：US15035101
申请日：2014-11-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Hospital Clinic de Barcelona , The Cleveland Clinic Foundation , The Board of Regents of the University of Nebraska , Oregon Health and Science University , Julius-Maximilians-University of Würzburg , Oslo University Hospital HF
发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger
IPC分类号： G01N33/48 , G16B25/00 , G16B5/00 , C12Q1/6886
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
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公开(公告)号：US20190153539A1
公开(公告)日：2019-05-23
申请号：US16094965
申请日：2017-04-20
申请人： The United States of America, as represented by the secretary, Dep. of Health and Human Service , British Columbia Cancer Agency Branch , Julius-Maximilians - University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook
IPC分类号： C12Q1/6886
摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
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公开(公告)号：US10697975B2
公开(公告)日：2020-06-30
申请号：US15630751
申请日：2017-06-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Board of Regents of the University of Nebraska , University of Rochester , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , G01N33/68 , G16B25/00 , C12Q1/6886 , G16B40/00
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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公开(公告)号：US20180011106A1
公开(公告)日：2018-01-11
申请号：US15630751
申请日：2017-06-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , Board of Regents of the University of Nebraska , University of Rochester , University of Arizona, Tech Transfer Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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8.发明申请公开(公告)号：US20160283653A1
公开(公告)日：2016-09-29
申请号：US15035101
申请日：2014-11-05
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DE PARTMENT OF HEALTH AND HUMAN SER , BRITISH COLUMBIA CANCER AGENCY BRANCH , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNINVERSITY OF ARIZONA , UNIVERSITAT DE BARCELONA , HOSPITAL CLINIC DE BARCELONA , CLEVELAND CLINIC , BORD OF REGENTS ON THE UNIVERSITY OF NEBRASKA , OREGON HEALTH & SCIENCE UNIVERSITY , JULIUS-MAXIMILIANS-UNIVERSITY OF WUERZBURG , OSLO UNIVERSITY HOSPITAL HF
发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs (Deceased) , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger
CPC分类号： G16B25/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/166 , G16B5/00
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
摘要翻译： 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样扩散性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活检样本。
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