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公开(公告)号：US11725248B2
公开(公告)日：2023-08-15
申请号：US16094965
申请日：2017-04-20
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Julius-Maximilians—University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
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公开(公告)号：US11574704B2
公开(公告)日：2023-02-07
申请号：US16746347
申请日：2020-01-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Hospital Clinic de Barcelona , The Cleveland Clinic Foundation , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians—University of Würzburg , Oslo University Hospital HF
发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger
IPC分类号： G01N33/48 , G16B25/10 , G16B25/00 , G16B5/00 , C12Q1/6886
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
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公开(公告)号：US10607717B2
公开(公告)日：2020-03-31
申请号：US15035101
申请日：2014-11-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Hospital Clinic de Barcelona , The Cleveland Clinic Foundation , The Board of Regents of the University of Nebraska , Oregon Health and Science University , Julius-Maximilians-University of Würzburg , Oslo University Hospital HF
发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger
IPC分类号： G01N33/48 , G16B25/00 , G16B5/00 , C12Q1/6886
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
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公开(公告)号：US11028444B2
公开(公告)日：2021-06-08
申请号：US15965510
申请日：2018-04-27
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Arizona Board of Regents on Behalf of the University of Arizona , Queen Mary University of London , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Oregon Health & Science University , University of Rochester , Hospital Clinic de Barcelona , Universitat de Barcelona , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Würzburg
发明人： Lisa M. Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaløy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George W. Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： G01N33/48 , C12Q1/6886 , G01N33/574
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
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公开(公告)号：US20190153539A1
公开(公告)日：2019-05-23
申请号：US16094965
申请日：2017-04-20
申请人： The United States of America, as represented by the secretary, Dep. of Health and Human Service , British Columbia Cancer Agency Branch , Julius-Maximilians - University of Würzburg , Oregon Health & Science University , Hospital Clinic de Barcelona , Universitat de Barcelona , Oslo University Hospital HF , Board of Regents of the University of Nebraska , The Cleveland Clinic Foundation , Mayo Foundation for Medical Education and Research
发明人： Louis M. Staudt , David William Scott , George W. Wright , Andreas Rosenwald , Pau Abrisqueta , Rita Braziel , Elias Campo Guerri , Wing C. Chan , Joseph M. Connors , Jan Delabie , Diego Villa , Kai Fu , Randy D. Gascoyne , Timothy Greiner , Elaine S. Jaffe , Pedro Jares , Anja Mottok , German Ott , Lisa M. Rimsza , Graham Slack , Dennis Weisenburger , Erlend B. Smeland , James Robert Cook
IPC分类号： C12Q1/6886
摘要： The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
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公开(公告)号：US09970059B2
公开(公告)日：2018-05-15
申请号：US14540302
申请日：2014-11-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Arizona Board of Regents on behalf of the University of Arizona , Queen Mary University of London , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Oregon Health & Science University , University of Rochester , Hospital Clinic de Barcelona , Universitat De Barcelona , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Wuerzburg
发明人： Lisa Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaloy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
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公开(公告)号：US20180245165A1
公开(公告)日：2018-08-30
申请号：US15965510
申请日：2018-04-27
申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Arizona Board of Regents on Behalf of the University of Arizona , Queen Mary University of London , Board of Regents of the University of Nebraska , Oslo University Hospital HF , Oregon Health & Science University , University of Rochester , Hospital Clinic de Barcelona , Universitat de Barcelona , British Columbia Cancer Agency Branch , Julius-Maximilians-University of Würzburg
发明人： Lisa M. Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaløy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George W. Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： C12Q1/6886 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
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8.发明申请公开(公告)号：US20160283653A1
公开(公告)日：2016-09-29
申请号：US15035101
申请日：2014-11-05
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DE PARTMENT OF HEALTH AND HUMAN SER , BRITISH COLUMBIA CANCER AGENCY BRANCH , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNINVERSITY OF ARIZONA , UNIVERSITAT DE BARCELONA , HOSPITAL CLINIC DE BARCELONA , CLEVELAND CLINIC , BORD OF REGENTS ON THE UNIVERSITY OF NEBRASKA , OREGON HEALTH & SCIENCE UNIVERSITY , JULIUS-MAXIMILIANS-UNIVERSITY OF WUERZBURG , OSLO UNIVERSITY HOSPITAL HF
发明人： Louis M. Staudt , George W. Wright , David William Scott , Joseph M. Connors , Randy D. Gascoyne , Lisa Rimsza , Elias Campo Guerri , Raymond Tubbs (Deceased) , Timothy C. Greiner , James Robert Cook , Kai Fu , Paul Michael Williams , Chih-Jian Lih , Elaine S. Jaffe , Rita M. Braziel , Andreas Rosenwald , Erlend B. Smeland , Wing C. Chan , German Ott , Jan Delabie , Dennis Weisenburger
CPC分类号： G16B25/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/166 , G16B5/00
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
摘要翻译： 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样扩散性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活检样本。
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公开(公告)号：US11326212B2
公开(公告)日：2022-05-10
申请号：US16148576
申请日：2018-10-01
发明人： Ryan D. Morin , Marco A. Marra , Andrew J. Mungall , Martin Hirst , Maria Mendez-Lago , Randy D. Gascoyne , Joseph M. Connors
IPC分类号： C12Q1/6886 , G01N33/574 , C07K14/705 , C40B30/04
摘要： The disclosure provides a method of identifying a subject as having B-cell non-Hodgkin lymphoma (NHL) such as testing a sample from a subject for a mutation in one or more biomarkers. Also described are methods for classifying or monitoring a subject having, or suspected of having, B-cell non-Hodgkin lymphoma comprising testing the sample for a mutation in one or more biomarkers.
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公开(公告)号：US09045801B2
公开(公告)日：2015-06-02
申请号：US13945439
申请日：2013-07-18
IPC分类号： C12Q1/68 , C12N9/10 , C07K16/40 , G01N33/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K16/40 , C12N9/1007 , C12Q2600/106 , C12Q2600/156 , C12Y201/01043 , G01N33/57407 , G01N33/6872 , G01N2800/52
摘要： The disclosure provides a method of identifying a subject as having B-cell non-Hodgkin lymphoma (NHL) such as testing a sample from a subject for a mutation in one or more biomarkers. Also described are methods for classifying or monitoring a subject having, or suspected of having, B-cell non-Hodgkin lymphoma comprising testing the sample for a mutation in one or more biomarkers.
摘要翻译： 本公开提供了将受试者鉴定为具有B细胞非霍奇金淋巴瘤（NHL）的方法，例如测试来自受试者的样品用于一种或多种生物标志物中的突变。 还描述了用于分类或监测具有或怀疑具有B细胞非霍奇金淋巴瘤的受试者的方法，包括测试样品中一种或多种生物标志物中的突变。
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