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公开(公告)号：US20210325651A1
公开(公告)日：2021-10-21
申请号：US17267567
申请日：2019-09-27
摘要： A microscopy device comprises a continuous or pulsed wave laser light source; a pair of parallel mirrors configured to receive light from the light source and reflect an array of incoherent light sheets; a beam encoder (e.g., frequency modulation reticle, Hadamard basis, random modulation pattern) to segment the array of incoherent light sheets and encode each light sheet with a respective frequency in reciprocal space; a lens configured to direct the encoded light sheets towards a biological sample; and an image capturing device configured to receive a fluorescence signal from the biological sample.
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公开(公告)号：US20240295484A1
公开(公告)日：2024-09-05
申请号：US18582156
申请日：2024-02-20
发明人： Kevin Kin Man TSIA , Chak Man LEE
IPC分类号： G01N15/1409 , G01N15/10 , G01N15/14 , G01N15/1404 , G01N15/149
CPC分类号： G01N15/1409 , G01N2015/1006 , G01N2015/1413 , G01N15/149 , G01N2015/1493
摘要： A high-throughput single-file focusing system and methods for polydisperse particles are provided. The system includes a microfluidic device for pre-focusing the polydisperse particles and a high-aspect-ratio (HAR) rectangular structure coupled to the microfluidic device. The microfluidic device includes a fluidic channel configured to localize distributions of the polydisperse particles in a cross-sectional area of the fluidic channel. The dimensions of the fluidic channel are configured to generate a converging secondary flow having four spiral vortices that drives the polydisperse particles to flow inward following a spiral path to be concentrated into a center of each spiral vortex such that the polydisperse particles are focused by the converging secondary flow without any inertial force. The coupled HAR rectangular structure receives the pre-focused polydisperse particles and further confines the particles to form a single file on its mid-plane.
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