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    Methods of delivering anti-restenotic agents from a stent
    1.
    发明申请
    Methods of delivering anti-restenotic agents from a stent 审中-公开
    从支架输送抗再狭窄剂的方法

    公开(公告)号：US20060178734A1

    公开(公告)日：2006-08-10

    申请号：US11325223

    申请日：2006-01-04

    申请人： Theodore Parker ,  John Shanley ,  Brett Trauthen ,  Frank Litvack ,  Stephen Diaz

    发明人： Theodore Parker ,  John Shanley ,  Brett Trauthen ,  Frank Litvack ,  Stephen Diaz

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2250/0068 ,  A61L2300/416 ,  A61L2300/602

    摘要： A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended, and substantially linear drug release profile. The method of substantially linear extended release increases the therapeutic effectiveness of administration of a given dosage. In one example, a method of reducing restenosis includes delivering paclitaxel from a stent to an artery at a minimum release rate of 1 percent of the total dosage of paclitaxel on the stent per day throughout an entire administration period from the time of implantation of the stent until the time that substantially all the paclitaxel is released from the stent.

    摘要翻译： 用于降低支架置入医疗干预后再狭窄水平的方法包括将需要治疗的受支配物，延长和基本上的支架的支架到血管组织的持续施用一定剂量的抗再狭窄剂如紫杉醇 线性药物释放曲线。 基本线性延长释放的方法增加给药剂量的给药的治疗有效性。 在一个实例中，减少再狭窄的方法包括将紫杉醇从支架输送到动脉，在从支架植入开始的整个施用期间，每天在支架上以最大释放速率将紫杉醇的总剂量的1％ 直到基本上所有的紫杉醇从支架释放出来。

    Bifurcation stent with crushable end and method for delivery of a stent to a bifurcation
    2.
    发明申请
    Bifurcation stent with crushable end and method for delivery of a stent to a bifurcation 审中-公开
    具有可压溃端的分叉支架和用于将支架输送到分叉的方法

    公开(公告)号：US20060079956A1

    公开(公告)日：2006-04-13

    申请号：US11200765

    申请日：2005-08-10

    申请人： Neal Eigler ,  Frank Litvack ,  John Shanley ,  Stephen Diaz

    发明人： Neal Eigler ,  Frank Litvack ,  John Shanley ,  Stephen Diaz

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/954 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0068

    摘要： A bifurcation stent includes a first end which is deformable or crushable at a lower force than a second end. The crushable first end and more rigid second end of the bifurcation stent allow one end of the stent to remain expanded in tissue supporting configuration in a side branch of a vessel bifurcation while the other end is easily crushed against the side wall of the main vessel into which it extends. A method of supporting a bifurcated body lumen with the bifurcation stent involves delivering the bifurcation stent in an unexpanded configuration to a bifurcation in a body lumen, positioning the bifurcation stent with the distal portion substantially within a side branch vessel of the bifurcation and the proximal crushable portion substantially within the main vessel, expanding the bifurcation stent, and expanding a main vessel stent along side the bifurcation stent and thereby crushing at least a portion of the crushable proximal portion of the bifurcation stent against the main vessel wall.

    摘要翻译： 分叉支架包括可在比第二端更低的力下变形或可压碎的第一端。 分叉支架的可破碎的第一端和更刚性的第二端允许支架的一端在血管分叉的侧支中的组织支撑构型中保持膨胀，而另一端容易被压在主血管的侧壁上 它扩展了。 使用分叉支架支撑分叉体腔的方法包括将未扩张构型中的分叉支架递送到体腔中的分叉，将分叉支架与远端部分基本上位于分叉的侧分支血管中并将近端可压溃 部分基本上在主容器内部，扩张分叉支架，并且使主血管支架沿着分叉支架一侧扩张，从而将分叉支架的可压溃近端部分的至少一部分压碎在主血管壁上。

    System and method for loading a beneficial agent into a medical device
    8.
    发明申请
    System and method for loading a beneficial agent into a medical device 失效
    将有益剂装载到医疗装置中的系统和方法

    公开(公告)号：US20060177564A1

    公开(公告)日：2006-08-10

    申请号：US11392184

    申请日：2006-03-28

    申请人： Stephen Diaz ,  Theodore Parker

    发明人： Stephen Diaz ,  Theodore Parker

    IPC分类号： A61L33/00 ,  B05D3/00

    CPC分类号： A61L31/146 ,  A61L31/16 ,  A61L2300/00

    摘要： The beneficial agent is applied into the holes in a medical device in a dry particulate form and is adhered in the hole in a manner that allows release of the drug in a controlled manner. The drug material would be formed into particles and placed in the holes. The solvent would be added to partially liquefy and adhere the drug into the holes. After application of the solvent, the particles are adhered together in a substantially uniform drug containing matrix. The particles may include drug alone or drug in combination with other materials including a matrix.

    摘要翻译： 将有益剂以干燥颗粒形式施加到医疗装置的孔中，并以允许以受控方式释放药物的方式粘附在孔中。 药物将形成颗粒并放置在孔中。 加入溶剂以部分液化并将药物粘附到孔中。 在施加溶剂之后，颗粒以基本均匀的含药基质粘合在一起。 颗粒可以包括单独的药物或与包括基质的其它材料组合的药物。

    System and method for loading a beneficial agent into holes in a medical device
    9.
    发明申请
    System and method for loading a beneficial agent into holes in a medical device 审中-公开
    将有益剂装载到医疗装置的孔中的系统和方法

    公开(公告)号：US20060222755A1

    公开(公告)日：2006-10-05

    申请号：US11392318

    申请日：2006-03-28

    申请人： Stephen Diaz ,  Theodore Parker

    发明人： Stephen Diaz ,  Theodore Parker

    IPC分类号： A61F2/06 ,  B05D3/00

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0068

    摘要： A system for loading a beneficial agent into holes in a medical device includes a punch system for punching plugs of beneficial agent from a thin sheet into the holes in the medical device. The loading of a beneficial agent in the form of a thin film allows the formation of multilayered structures within the holes to control release kinetics and prevent any meniscus which occurs when a beneficial agent is deposited as a liquid in the holes and dried. The punch type loading system also can provide the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.

    摘要翻译： 用于将有益剂装载到医疗装置中的孔中的系统包括用于将有益剂的塞子从薄片冲压到医疗装置中的孔中的冲头系统。 以薄膜形式加载有益剂允许在孔内形成多层结构以控制释放动力学并防止当将有益剂作为液体沉积在孔中并干燥时发生的任何弯液面。 打孔式加载系统还可以提供递送包括蛋白质，酶，抗体，反义，核酶，基因/载体构建体和包括内皮细胞在内的细胞的大的潜在敏感分子的能力。

    Electropolishing apparatus and method for implantable medical devices
    10.
    发明申请
    Electropolishing apparatus and method for implantable medical devices 有权
    可植入医疗器械的电抛光设备及方法

    公开(公告)号：US20070034527A1

    公开(公告)日：2007-02-15

    申请号：US11503376

    申请日：2006-08-11

    申请人： Stephen Diaz ,  Jeffrey Anderson

    发明人： Stephen Diaz ,  Jeffrey Anderson

    IPC分类号： B23H7/00

    CPC分类号： C25F7/00 ,  A61F2/82 ,  C25F3/16

    摘要： An electropolishing device for polishing a cylindrical medical device such as a stent includes anodes in the form of rollers arranged to contact an exterior surface of the device. A drive mechanism rotates the anodes periodically during the electropolishing process to change a contact point between the anodes and the medical device. A tilting mechanism can also be used for periodically tilting the anodes during the electropolishing process to allow bubbles to escape from one end of the stent.

    摘要翻译： 用于抛光诸如支架的圆柱形医疗装置的电抛光装置包括布置为接触装置的外表面的辊形式的阳极。 驱动机构在电抛光过程期间周期性地旋转阳极以改变阳极和医疗装置之间的接触点。 倾斜机构还可用于在电抛光过程期间周期性地倾斜阳极以允许气泡从支架的一端逸出。