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![Administration of (3S)-N-hydroxy-4-(sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxamide or (S)-N_hydroxy-4-[4_(but-2-ynyloxy)phenylsulfonyl]-2,2-dimethyl thimomorpholine-3-carboxamide for preventing and/or treating inflammatory skin pathologies/afflictions](/abs-image/US/2009/05/28/US20090137569A1/abs.jpg.150x150.jpg)
1.发明申请Administration of (3S)-N-hydroxy-4-(sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxamide or (S)-N_hydroxy-4-[4_(but-2-ynyloxy)phenylsulfonyl]-2,2-dimethyl thimomorpholine-3-carboxamide for preventing and/or treating inflammatory skin pathologies/afflictions 审中-公开（3S）-N-羟基-4-（磺酰基）-2,2-二甲基-3-硫代吗啉羧酰胺或（S）-N-羟基-4- [4-（丁-2-炔基氧基）苯基磺酰基] -2,2 - 二甲基硫代吗啉-3-甲酰胺，用于预防和/或治疗炎性皮肤病理/病症公开(公告)号：US20090137569A1
公开(公告)日：2009-05-28
申请号：US12232456
申请日：2008-09-17
申请人： Thibaud Biadatti , Marlene Schuppli
发明人： Thibaud Biadatti , Marlene Schuppli
CPC分类号： A61K31/54
摘要： Inflammatory skin pathologies/afflictions, e.g., eczema or psoriasis, are prevented and/or treated by administering to a subject in need of such treatment, a thus effective amount of at least one compound of following formula (I): in which R is a —CH3 radical or a CH2OH radical, or of a pharmaceutically acceptable salt, solvate or hydrate thereof.
摘要翻译： 通过向需要这种治疗的受试者施用如此有效量的至少一种下列通式（I）化合物来预防和/或治疗炎性皮肤病理/病症，例如湿疹或牛皮癣：其中R是 -CH 3基或CH 2 OH基，或其药学上可接受的盐，溶剂合物或水合物。
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![N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors](/abs-image/US/2015/08/25/US09115102B2/abs.jpg.150x150.jpg)
2.发明授权N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors 有权N- [2-羟基氨基甲酰基-2-（哌嗪基）乙基]苯甲酰胺化合物，其制备及其作为TACE抑制剂的用途公开(公告)号：US09115102B2
公开(公告)日：2015-08-25
申请号：US13496637
申请日：2010-09-16
IPC分类号： C07D295/26 , A61K31/495 , C07D209/12 , C07D211/22 , C07D213/30 , C07D215/14 , C07D231/12 , C07D233/02 , C07D307/79 , C07D401/12 , C07D471/04
CPC分类号： C07D295/26 , C07D209/12 , C07D211/22 , C07D213/30 , C07D215/14 , C07D231/12 , C07D233/02 , C07D307/79 , C07D401/12 , C07D471/04
摘要： The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.
摘要翻译： 本发明涉及具有对应于通式（I）的结构的新的苯 - 甲酰胺化合物，以及它们的合成方法及其在预期用于人或兽医学或其使用的药物组合物中的用途 在化妆品组合物中。
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3.发明申请NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS 有权新型苯并噻二唑化合物，其合成方法及其在医药中的用途如同化妆品公开(公告)号：US20120323006A1
公开(公告)日：2012-12-20
申请号：US13381234
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlene Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlene Schuppli
IPC分类号： C07D295/26 , C07D471/04 , C07D413/12 , C07D401/12 , C07D403/12
CPC分类号： C07D215/14 , A61K31/4965 , A61K31/497 , A61K31/551 , C07D209/10 , C07D209/12 , C07D209/20 , C07D209/24 , C07D209/26 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/68 , C07D261/20 , C07D295/15 , C07D295/26 , C07D471/04 , Y02A50/411
摘要： Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
摘要翻译： 描述具有式（I）结构的苯磺酰胺化合物。 还描述了用于合成化合物的方法及其在人或兽医学药物组合物和化妆品组合物中的用途。
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![N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS](/abs-image/US/2012/07/12/US20120178934A1/abs.jpg.150x150.jpg)
4.发明申请N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS 有权N- [2-羟基碳酰氨基-2-（哌嗪基）乙基]苯甲酰胺化合物，其制备及其作为抑制剂的用途公开(公告)号：US20120178934A1
公开(公告)日：2012-07-12
申请号：US13496637
申请日：2010-09-16
IPC分类号： C07D401/12 , C07D405/12 , C07D471/04 , C07D295/26
CPC分类号： C07D295/26 , C07D209/12 , C07D211/22 , C07D213/30 , C07D215/14 , C07D231/12 , C07D233/02 , C07D307/79 , C07D401/12 , C07D471/04
摘要： The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.
摘要翻译： 本发明涉及具有对应于通式（I）的结构的新的苯 - 甲酰胺化合物，以及它们的合成方法及其在预期用于人或兽医学或其使用的药物组合物中的用途 在化妆品组合物中。
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5.发明申请NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS 失效新型苯并噻二唑化合物，其合成方法及其在医药中的用途如同化妆品公开(公告)号：US20120116072A1
公开(公告)日：2012-05-10
申请号：US13381237
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Pascale Mauvais , Olivier Roye , Marlene Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Pascale Mauvais , Olivier Roye , Marlene Schuppli
IPC分类号： C07D401/02 , C07D417/02 , C07D207/46 , C07D471/02 , C07D211/22 , C07D223/12 , C07D265/32
CPC分类号： C07D295/15 , C07D401/12
摘要： Benzenesulfonamide compounds having a structure of the following general formula (I) are described. Also described, are methods for synthesizing the compounds, and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
摘要翻译： 描述具有以下通式（I）的结构的苯磺酰胺化合物。 还描述了用于合成化合物的方法及其用于人或兽医学药物组合物和化妆品组合物中的用途。
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