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公开(公告)号：US08470358B2
公开(公告)日：2013-06-25
申请号：US13276666
申请日：2011-10-19
CPC分类号： A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
摘要： Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
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公开(公告)号：US20120034222A1
公开(公告)日：2012-02-09
申请号：US13276666
申请日：2011-10-19
CPC分类号： A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
摘要： Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
摘要翻译： 提供了具有能够催化体内产生一氧化氮的催化剂的医疗装置和使用该装置治疗血管状态的方法。
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公开(公告)号：US08067025B2
公开(公告)日：2011-11-29
申请号：US11726135
申请日：2007-03-20
CPC分类号： A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
摘要： Medical devices having a catalyst capable of catalyzing the generation of nitric oxide attached to the medical device and methods of treating a vascular condition using the devices are provided.
摘要翻译： 提供了具有能够催化附着于医疗装置的一氧化氮的产生的催化剂的医疗装置和使用该装置治疗血管状态的方法。
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公开(公告)号：US08828069B2
公开(公告)日：2014-09-09
申请号：US12546534
申请日：2009-08-24
申请人： Lothar W. Kleiner , Jessica Reneé´ DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar W. Kleiner , Jessica Reneé´ DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
摘要： A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
摘要翻译： 提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。
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5.发明授权公开(公告)号：US08658194B2
公开(公告)日：2014-02-25
申请号：US12909668
申请日：2010-10-21
申请人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
发明人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译： 公开了一种分段聚氨酯和两亲无规或嵌段共聚物。 分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。
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6.发明授权公开(公告)号：US08309112B2
公开(公告)日：2012-11-13
申请号：US10746483
申请日：2003-12-24
申请人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
发明人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
IPC分类号： A61K13/00
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译： 公开了一种分段聚氨酯和两亲无规或嵌段共聚物。 分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。
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7.发明授权Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 有权用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US08846069B2
公开(公告)日：2014-09-30
申请号：US12762718
申请日：2010-04-19
申请人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
发明人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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8.发明授权Controlling moisture in and plasticization of bioresorbable polymer for melt processing 有权控制生物可吸收聚合物的水分和塑化，用于熔体加工公开(公告)号：US08841412B2
公开(公告)日：2014-09-23
申请号：US13207656
申请日：2011-08-11
申请人： Bethany Steichen , Stephen D. Pacetti , Manish Gada , Thierry Glauser , Lothar W. Kleiner , Yunbing Wang , James P. Oberhauser , Ni Ding
发明人： Bethany Steichen , Stephen D. Pacetti , Manish Gada , Thierry Glauser , Lothar W. Kleiner , Yunbing Wang , James P. Oberhauser , Ni Ding
IPC分类号： C08F6/00
CPC分类号： B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
摘要： Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
摘要翻译： 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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9.发明授权Methods for fabricating coatings for drug delivery devices having gradient of hydration 有权用于制备具有水化梯度的药物递送装置的涂层的方法公开(公告)号：US08277926B2
公开(公告)日：2012-10-02
申请号：US12016820
申请日：2008-01-18
CPC分类号： A61L31/10 , A61F2250/0067 , A61L2420/08 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要： A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a lower degree of hydration than the first polymer.
摘要翻译： 提供了一种用于制造可植入医疗装置的涂层的方法，包括在所述装置的至少一部分上施加第一聚合物以形成第一层涂层，并在第一层的至少一部分上施加第二聚合物以形成 涂层的第二层。 第二聚合物的水合度比第一聚合物低。
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10.发明申请Methods For Fabricating Coatings For Drug Delivery Devices Having Gradient Of Hydration 有权用于制备具有水化梯度的药物递送装置的涂层的方法公开(公告)号：US20080138497A1
公开(公告)日：2008-06-12
申请号：US12016804
申请日：2008-01-18
IPC分类号： A61L27/26
CPC分类号： A61L31/10 , A61F2250/0067 , A61L2420/08 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要： A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a higher degree of hydration than the first polymer. The first or second polymer can comprise a polyorthoester.
摘要翻译： 提供了一种用于制造可植入医疗装置的涂层的方法，包括在所述装置的至少一部分上施加第一聚合物以形成所述涂层的第一层，并在所述第一层的至少一部分上施加第二聚合物以形成 涂层的第二层。 第二聚合物具有比第一聚合物更高的水合度。 第一或第二聚合物可以包含聚原酸酯。
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